scholarly journals THE REMODELING OF LEFT ATRIUM AND VASODILATION FACTORS CHANGES IN ISCHEMIC HEART FAILURE

2017 ◽  
Author(s):  
V. I. Denesyuk ◽  
O. V. Denesyuk ◽  
N. O. Muzyka
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Atrium ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Stable Coronary Heart Disease

Background. According to the national registries of European countries and epidemiological studies, the prevalence of chronic heart failure (CHF) among adults is 2,0-5,0%, and increases due to age, in people aged over 70 years old it is 10,0-20,0%.Objective. To find out the specific features of remodeling of the left atrium and change of vasodilation factors in ischemic heart failure with reduced and preserved left ventricular ejection fraction and to establish correlation relationships.Methods. A full clinical examination of 153 patients with CHF (105 men and 48 women) was conducted to achieve this objective. The surveyed patients underwent clinical examinations; spectrophotometric parameters: quantification of markers of vasodilation, metabolites of monoxide nitrogen – nitrates and nitrites with Gris reagent; content of endothelial nitric oxide synthase (eNOS) in serum - ELISA for the set of Nitric Oxide Synthase 3, Endothelial (NOS3) Human ELISA Kit (Cloud-Clone Corp, USA). Electrocardiographic (ECG) examination was conducted in 12 standard conventional leads on electrocardiograph by the Hungarian production Heart Screen 112 D.Results. The 1st group of the examined patients with reduced LV EF prevails III (significant) degree LA dilatation in 33 (70.21%) cases, II (moderate) degree of LA dilatation was determined in 14 (29.78%), and I (initial) degree was not defined at all. In the 2nd group of the patients with preserved LV EF mainly the II degree of LA dilatation was determined in 44 (44.51%) cases, and decreased LA dilation in 39 (36.79%) cases (p<0.01), and III degree of LA dilation was defined in 23 (21.69%) cases (p<0.01). In patients with stable coronary heart disease, complicated by heart failure with reduced LV EF and II degree of LA dilatation, eNOS levels in the serum was 449.00±39.91 pg/ml, whereas in patients with stable coronary heart disease, complicated by heart failure with preserved LV EF and II stage of LA dilatation – 673.56±50.98 pg/ml (p<0.01). At III stage of LA dilatation in patients of the 1st group level eNOS was 344.20±51.98 pg/ml in the patients of the 2nd group – 616.90±36.49 pg/ml (p<0.01). At the same degree and with LA dilation in the patients of the 2nd group eNOS was 750.27±99.85 pg/ml. Conclusions. The structural and functional changes of the left atrium and changing factors of vasodilation in patients with stable coronary artery disease of II-III functional classes complicated by heart failure of I-III functional classes are studied. It is established that in the examined patients with stable coronary heart disease complicated by heart failure with reduced left ventricular ejection fraction mainly III (significant) degree of dilatation of the left atrium was determined, while in patients with stable coronary heart disease, complicated by heart failure with preserved left ventricular ejection fraction mainly II (moderate) degree of dilation of the left atrium was determined. In comparison with the results of research among the patients with stable coronary heart disease, complicated by heart failure with reduced left ventricular ejection fraction, and a group of patients with preserved left ventricular ejection fraction, it was determined a significant decrease in eNOS, nitrites, total amount of nitrites and nitrates.

scholarly journals LITERATURE REVIEW: EFFECTIVENESS OF CARDIAC REHABILITATION IN PATIENTS WITH CORONARY HEART DISEASE

2020 ◽  
Vol 4 (2) ◽  
pp. 141-152
Author(s):  
Ika Ainur Rofi'ah ◽  
Eka Nur So'emah
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Left Ventricular Ejection Fraction ◽  
Literature Review ◽  
Ejection Fraction ◽  
Cardiac Rehabilitation ◽  
Functional Capacity ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Background: Cardiac rehabilitation is an evidence-based intervention that includes physical exercise, health education, and modification of health behavior in patients with cardiovascular disease. Cardiac rehabilitation is considered as secondary prevention after acute coronary syndrome and improves treatment outcomes in patients with coronary heart disease. This literature review aimed to evaluate the effectiveness of cardiac rehabilitation in coronary heart disease patients. Methods: This present study was a literature review discussing cardiac rehabilitation for coronary heart disease patients. Results: The result showed that the functional capacity of the CR group was more increased compared to non-CR (p <0.001; α <0.05), left ventricular ejection fraction (LVEF) significantly increased in the CR group (p < 0.05; α <0.05), the medical cost of CR group was lower significantly (p=0.042; α <0.05), and the risk of recurrence rate was significantly lower in CR group (p=0.004; α <0.05). Conclusions: Cardiac rehabilitation is known to increase functional capacity, increase left ventricular ejection fraction (LVEF), reduce medical costs, and reduce the recurrence rate of patients with CHD.

scholarly journals Relação entre classe funcional e fração de ejeção do ventrículo esquerdo em pacientes com doença coronariana candidatos à reabilitação cardíaca

2017 ◽  
Vol 27 (3) ◽  
pp. 26652
Author(s):  
Isabella Martins de Albuquerque ◽  
Andrieli Barbieri Garlet ◽  
Dannuey Machado Cardoso ◽  
Tamires Daros Santos ◽  
Sérgio Nunes Pereira
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Medical Records ◽  
Left Ventricular ◽  
Functional Class ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

***Relationship between functional class and left ventricular ejection fraction in patients with coronary heart disease who were candidates for cardiac rehabilitation***AIMS: To assess the potential relation between the New York Heart Association functional class and left ventricular ejection fraction in coronary heart disease patients who were candidates for cardiac rehabilitation.METHODS: This is a retrospective cross-sectional study based on the analysis of medical records of coronary heart disease patients who were candidates for the Cardiac Rehabilitation Program of Hospital Universitário de Santa Maria, state of Rio Grande do Sul, Brazil. Both male and female patients aged 50 to 65 were included, whereas patients with chronic renal failure, anemia, poor echocardiographic image quality, non-sinus rhythm, and also those individuals whose medical records lacked sufficient information were excluded. Data were collected from August 2015 to March 2016, and the information that made up the variables of interest was extracted from the medical records, such as: clinical and demographic data (sex, age, comorbidities, clinical diagnosis, surgical and drug treatment), left ventricular ejection fraction values obtained by echocardiography (conventional and tissue Doppler echocardiography), and functional class from the ergometric test. Statistical analysis was performed using Kruskal-Wallis test followed by Dunn’s post-hoc test.  The significance level was set at p<0.05.RESULTS: A total of 131 medical records were consecutively evaluated, of which 102 met the inclusion criteria. Mean age was 59.23±7.95 years and 70 (68.63%) patients were male, with a predominance of functional class I. There was an inverse relation between functional class and ejection fraction: the more advanced the functional class, the more compromised the cardiac performance (p=0.036).CONCLUSIONS: In this sample of patients with coronary heart disease who were candidates for cardiac rehabilitation, there was an inverse relation between left ventricular ejection fraction and functional class. This finding provides information about the limitations imposed by the disease on patient’s exercise capacity and heart function and can contribute to the development of a physical training program.

scholarly journals Trends in Left Ventricular Ejection Fraction for Patients With a New Diagnosis of Heart Failure

2020 ◽  
Vol 13 (9) ◽  
Author(s):  
Rebecca L. Tisdale ◽  
François Haddad ◽  
Shun Kohsaka ◽  
Paul A. Heidenreich
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Ischemic Heart Disease ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Ischemic Heart ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Background: The left ventricular ejection fraction (LVEF) guides treatment of heart failure, yet this data has not been systematically collected in large data sets. We sought to characterize the epidemiology of incident heart failure using the initial LVEF. Methods: We identified 219 537 patients in the Veterans Affairs system between 2011 and 2017 who had an LVEF documented within 365 days before and 30 days after the heart failure diagnosis date. LVEF was obtained from natural language processing from imaging and provider notes. In multivariate analysis, we assessed characteristics associated with having an initial LVEF <40%. Results: Most patients were male and White; a plurality were within the 60 to 69 year age decile. A majority of patients had ischemic heart disease and a high burden of co-morbidities. Over time, presentation with an LVEF <40% became slightly less common, with a nadir in 2015. Presentation with an initial LVEF <40% was more common in younger patients, men, Black and Hispanic patients, an inpatient presentation, lower systolic blood pressure, lower pulse pressure, and higher heart rate. Ischemic heart disease, alcohol use disorder, peripheral arterial disease, and ventricular arrhythmias were associated with an initial LVEF <40%, while most other comorbid conditions (eg, atrial fibrillation, chronic obstructive pulmonary disease, malignancy) were more strongly associated with an initial LVEF >50%. Conclusions: For patients with heart failure, particularly at the extremes of age, an initial preserved LVEF is common. In addition to clinical characteristics, certain races (Black and Hispanic) were more likely to present with a reduced LVEF. Further studies are needed to determine if racial differences are due to patient or health systems issues such as access to care.

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