scholarly journals Liver Function Tests in Chronic Congestive Heart Failure

Circulation ◽  
1950 ◽  
Vol 2 (2) ◽  
pp. 286-297 ◽  
Author(s):  
LEONARD FELDER ◽  
ALVIN MUND ◽  
JULIUS G. PARKER
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Liver Function ◽  
Liver Function Tests ◽  
Chronic Congestive Heart Failure ◽  
Function Tests

Studies on liver function tests and blood clotting factors in congestive heart failure

1966 ◽  
Vol 1 (1) ◽  
pp. 32-32
Author(s):  
A. Minagawa ◽  
H. Hannya ◽  
K. Yahata ◽  
E. Nakata ◽  
T. Tazaki ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Liver Function ◽  
Blood Clotting ◽  
Liver Function Tests ◽  
Clotting Factors ◽  
Function Tests ◽  
Blood Clotting Factors

scholarly journals Abnormal Liver Function Tests and Long-Term Outcomes in Patients Discharged after Acute Heart Failure

2021 ◽  
Vol 10 (8) ◽  
pp. 1730
Author(s):  
Hiroshi Miyama ◽  
Yasuyuki Shiraishi ◽  
Shun Kohsaka ◽  
Ayumi Goda ◽  
Yosuke Nishihata ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Adverse Outcomes ◽  
Long Term Outcomes ◽  
Function Tests ◽  
Parameter Values

Abnormal liver function tests (LFTs) are known to be associated with impaired clinical outcomes in heart failure (HF) patients. However, this implication varies with each single LFT panel. We aim to evaluate the long-term outcomes of acute HF (AHF) patients by assessing multiple LFT panels in combination. From a prospective multicenter registry in Japan, 1158 AHF patients who were successfully discharged were analyzed (mean age, 73.9 ± 13.5 years; men, 58%). LFTs (i.e., total bilirubin, aspartate aminotransferase or alanine aminotransferase, and alkaline phosphatase) at discharge were assessed; borderline and abnormal LFTs were defined as 1 and ≥2 parameter values above the normal range, respectively. The primary endpoint was composite of all-cause death or HF readmission. At the time of discharge, 28.7% and 8.6% of patients showed borderline and abnormal LFTs, respectively. There were 196 (16.9%) deaths and 298 (25.7%) HF readmissions during a median 12.4-month follow-up period. The abnormal LFTs group had a significantly higher risk of experiencing the composite outcome (adjusted hazard ratio: 1.51, 95% confidence interval: 1.08–2.12, p = 0.017), whereas the borderline LFTs group was not associated with higher risk of adverse events when referenced to the normal LFTs group. Among AHF patients, the combined elevation of ≥2 LFT panels at discharge was associated with long-term adverse outcomes.

scholarly journals Prognostic Implication of Liver Function Tests in Heart Failure With Preserved Ejection Fraction Without Chronic Hepatic Diseases: Insight From TOPCAT Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Weihao Liang ◽  
Xin He ◽  
Dexi Wu ◽  
Ruicong Xue ◽  
Bin Dong ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Ejection Fraction ◽  
Cardiovascular Mortality ◽  
Primary Outcome ◽  
Prognostic Significance ◽  
Liver Function Tests ◽  
Preserved Ejection Fraction ◽  
Hepatic Diseases ◽  
Function Tests

Background: Liver dysfunction is prevalent in patients with heart failure (HF), but the prognostic significance of liver function tests (LFTs) remains controversial. Heart failure with preserved ejection fraction (HFpEF) had been introduced for some time, but no previous study had focused on LFTs in HFpEF. Thus, we aim to evaluate the prognostic significance of LFTs in well-defined HFpEF patients.Methods and Results: We conveyed a post-hoc analysis of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial (TOPCAT). The primary outcome was the composite of cardiovascular mortality, HF hospitalization, and aborted cardiac arrest, and the secondary outcomes were cardiovascular mortality and HF hospitalization. In Cox proportional hazards models, aspartate transaminase (AST) and alanine transaminase (ALT) were not associated with any of the outcomes. On the contrary, increases in total bilirubin (TBIL) and alkaline phosphatase (ALP) were associated with increased risks of the primary outcome [TBIL: adjusted hazard ratio (HR), 1.17; 95% confidence interval (CI) 1.08–1.26; ALP: adjusted HR, 1.12; 95% CI 1.04–1.21], cardiovascular mortality (TBIL: adjusted HR, 1.16; 95% CI 1.02–1.31; ALP: adjusted HR, 1.16; 95% CI 1.05–1.28), and HF hospitalization (TBIL: adjusted HR, 1.22; 95% CI 1.12–1.33; ALP: adjusted HR, 1.12; 95% CI 1.03–1.23).Conclusion: Elevated serum cholestasis markers TBIL and ALP were significantly associated with a poor outcome in HFpEF patients without chronic hepatic diseases, while elevated ALT and AST were not.

How to interpret liver function tests in heart failure patients?

2020 ◽  
Vol 26 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Kumral Cagli ◽  
◽  
Fatma Nurcan Basar ◽  
Derya Tok ◽  
Osman Turak ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Liver Function Tests ◽  
Heart Failure Patients ◽  
Function Tests

scholarly journals Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study

2016 ◽  
Vol 18 (7) ◽  
pp. 830-839 ◽  
Author(s):  
Jan Biegus ◽  
Hans L. Hillege ◽  
Douwe Postmus ◽  
Mattia. A.E. Valente ◽  
Daniel M. Bloomfield ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Acute Heart Failure ◽  
Clinical Characteristics ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Function Tests ◽  
Protect Study

scholarly journals Liver function tests in patients with acute heart failure and associated outcomes: insights from ASCEND-HF

2015 ◽  
Vol 18 (4) ◽  
pp. 424-432 ◽  
Author(s):  
Marc D. Samsky ◽  
Allison Dunning ◽  
Adam D. DeVore ◽  
Phillip J. Schulte ◽  
Randall C. Starling ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Acute Heart Failure ◽  
Liver Function Tests ◽  
Function Tests

Altered liver function of chronic congestive heart failure

1952 ◽  
Vol 13 (6) ◽  
pp. 704-712 ◽  
Author(s):  
John M. Evans ◽  
Hyman J. Zimmerman ◽  
J.Grant Wilmer ◽  
Lawrence J. Thomas ◽  
Clayton B. Ethridge
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Liver Function ◽  
Chronic Congestive Heart Failure ◽  
Altered Liver

scholarly journals Liver function tests in patients with acute heart failure

2012 ◽  
Vol 122 (10) ◽  
pp. 471-479 ◽  
Author(s):  
Jan Biegus ◽  
Robert Zymliński ◽  
Mateusz Sokolski ◽  
Sylwia Nawrocka ◽  
Paweł Siwołowski ◽  
...  
Keyword(s):  
Heart Failure ◽  
Liver Function ◽  
Acute Heart Failure ◽  
Liver Function Tests ◽  
Function Tests
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