Association Between Serum Amyloid A Proteins and Coronary Artery Disease

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 2914-2919 ◽  
Author(s):  
Alistair I. Fyfe ◽  
L.S. Rothenberg ◽  
Frederick C. DeBeer ◽  
Rita M. Cantor ◽  
Jerome I. Rotter ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Artery Disease

A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease

2004 ◽  
Vol 174 (2) ◽  
pp. 349-356 ◽  
Author(s):  
Ken Ogasawara ◽  
Shinichi Mashiba ◽  
Youichiro Wada ◽  
Makoto Sahara ◽  
Kazuo Uchida ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Marker ◽  
Serum Amyloid A ◽  
Stable Coronary Artery Disease ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Artery Disease

scholarly journals Relationship between serum amyloid A and coronary artery disease in women: The NHLBI-sponsored women's ischemia syndrome evaluation (WISE) study

2003 ◽  
Vol 41 (6) ◽  
pp. 262
Author(s):  
B. Delia Johnson ◽  
Kevin Kip ◽  
Paul M. Ridker ◽  
Tjendimin Tjandrawan ◽  
C. Noel Bairey Merz ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Artery Disease

Serum amyloid A levels are associated with coronary artery disease: the Cedars-Sinai family study

1994 ◽  
Vol 109 (1-2) ◽  
pp. 18
Author(s):  
A.I. Fyfe ◽  
L. Castellani ◽  
J. Rotter ◽  
A.J. Lusis
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Family Study ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Artery Disease

3P-0907 A serum amyloid A and LDL complex as a new prognostic marker in stable coronary artery disease

2003 ◽  
Vol 4 (2) ◽  
pp. 261
Author(s):  
M. Sahara ◽  
K. Ogasawara ◽  
S. Mashiba ◽  
Y. Wada ◽  
K. Uchida ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Prognostic Marker ◽  
Serum Amyloid A ◽  
Stable Coronary Artery Disease ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Artery Disease

scholarly journals Serum Amyloid A as a Predictor of Coronary Artery Disease and Cardiovascular Outcome in Women

Circulation ◽  
2004 ◽  
Vol 109 (6) ◽  
pp. 726-732 ◽  
Author(s):  
B. Delia Johnson ◽  
Kevin E. Kip ◽  
Oscar C. Marroquin ◽  
Paul M Ridker ◽  
Sheryl F. Kelsey ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Cardiovascular Outcome ◽  
Amyloid A ◽  
Artery Disease

scholarly journals Effects of Serum Amyloid A and Lysophosphatidylcholine on Intracellular Calcium Concentration in Human Coronary Artery Smooth Muscle Cells

2011 ◽  
Vol 52 (3) ◽  
pp. 185-193 ◽  
Author(s):  
Tomofumi Tanaka ◽  
Kenichi Ikeda ◽  
Yumiko Yamamoto ◽  
Haruko Iida ◽  
Hironobu Kikuchi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Coronary Artery ◽  
Smooth Muscle Cells ◽  
Intracellular Calcium ◽  
Calcium Concentration ◽  
Serum Amyloid A ◽  
Muscle Cells ◽  
Serum Amyloid ◽  
Human Coronary Artery ◽  
Amyloid A

Abstract 84: Serum Amyloid A Does Not Modulate the Inverse Association of HDL with Coronary Artery Calcification in Type 2 Diabetes

2013 ◽  
Vol 33 (suppl_1) ◽  
Author(s):  
Claire K Mulvey ◽  
Timothy W Churchill ◽  
Karen Terembula ◽  
Jane F Ferguson ◽  
Nehal N Mehta ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Logistic Regression ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Inverse Association ◽  
Tobit Regression ◽  
Amyloid A

Introduction Although high-density lipoprotein (HDL) is inversely correlated with cardiovascular risk, HDL loses its protective role in pathologic inflammatory states like type 2 diabetes (T2DM). HDL dysfunction contributes to accelerated atherosclerosis in T2DM, but the mechanism is incompletely defined. The acute phase reactant serum amyloid A (SAA) displaces apolipoprotein A-I and may impair HDL-mediated reverse cholesterol efflux. We hypothesized that SAA alters the inverse association between HDL and coronary artery calcium (CAC) in the Penn Diabetes Heart Study, a cross-sectional study of T2DM patients free of overt cardiovascular or renal disease. Methods We measured SAA in serum samples by immunonephelometry (N=975; mean age 58 ± 9 years; 63% male, 57% Caucasian; mean BMI 33 ± 6 kg/m 2 ). HDL was measured enzymatically in lipoprotein fractions after ultracentrifugation. Agatston CAC scores were quantified from electron beam tomography at the same visit. Spearman correlation and logistic regression were used to test associations of SAA with clinical factors and metabolic syndrome. We used Tobit regression to analyze associations between CAC and HDL, both overall and stratified by 3 categories of SAA: undetectable, lower half detectable, and upper half detectable. Results Spearman correlations revealed moderate association of SAA with C-reactive protein (r=0.52) and weak associations of SAA with BMI (r=0.25) and HDL (r=0.17; all p<0.001). In logistic regression, the group with highest SAA levels had increased odds of metabolic syndrome compared to those with undetectable levels (OR 1.56, 95% CI 1.03 to 2.38, p=0.036). In adjusted Tobit regression, HDL was inversely associated with CAC (Tobit coefficient for 1-SD increase in HDL: -0.30; 95% CI -0.54 to -0.06; p=0.013). Across the categories of SAA, however, there was no difference in the association of HDL with CAC (Tobit coefficient for 1-SD increase in HDL: -0.17 [95% CI -0.49 to 0.16] for undetectable vs. -0.31 [95% CI -0.79 to 0.17] for lower half detectable vs. -0.49 [95% CI -1.01 to 0.03] for upper half detectable). Conclusions Despite the association of SAA with metabolic syndrome, these data suggest that elevated SAA may not change the inverse relationship of HDL with CAC in T2DM.

Serum amyloid A activation of human coronary artery endothelial cells exhibits a neutrophil promoting molecular profile

2013 ◽  
Vol 90 ◽  
pp. 55-63 ◽  
Author(s):  
Katja Lakota ◽  
Katjusa Mrak-Poljsak ◽  
Borut Bozic ◽  
Matija Tomsic ◽  
Snezna Sodin-Semrl
Keyword(s):  
Endothelial Cells ◽  
Coronary Artery ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Molecular Profile ◽  
Human Coronary Artery ◽  
Amyloid A

scholarly journals Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells

2008 ◽  
Vol 295 (6) ◽  
pp. H2399-H2408 ◽  
Author(s):  
Xinwen Wang ◽  
Hong Chai ◽  
Zehao Wang ◽  
Peter H. Lin ◽  
Qizhi Yao ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Coronary Artery ◽  
Endothelial Dysfunction ◽  
Coronary Arteries ◽  
Molecular Mechanisms ◽  
Serum Amyloid A ◽  
Serum Amyloid ◽  
Dependent Manner ◽  
Amyloid A ◽  
Enos Mrna

The objective of this study was to determine the effects and mechanisms of serum amyloid A (SAA) on coronary endothelial function. Porcine coronary arteries and human coronary arterial endothelial cells (HCAECs) were treated with SAA (0, 1, 10, or 25 μg/ml). Vasomotor reactivity was studied using a myograph tension system. SAA significantly reduced endothelium-dependent vasorelaxation of porcine coronary arteries in response to bradykinin in a concentration-dependent manner. SAA significantly decreased endothelial nitric oxide (NO) synthase (eNOS) mRNA and protein levels as well as NO bioavailability, whereas it increased ROS in both artery rings and HCAECs. In addition, the activities of internal antioxidant enzymes catalase and SOD were decreased in SAA-treated HCAECs. Bio-plex immunoassay analysis showed the activation of JNK, ERK2, and IκB-α after SAA treatment. Consequently, the antioxidants seleno-l-methionine and Mn(III) tetrakis-(4-benzoic acid)porphyrin and specific inhibitors for JNK and ERK1/2 effectively blocked the SAA-induced eNOS mRNA decrease and SAA-induced decrease in endothelium-dependent vasorelaxation in porcine coronary arteries. Thus, SAA at clinically relevant concentrations causes endothelial dysfunction in both porcine coronary arteries and HCAECs through molecular mechanisms involving eNOS downregulation, oxidative stress, and activation of JNK and ERK1/2 as well as NF-κB. These findings suggest that SAA may contribute to the progress of coronary artery disease.

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