scholarly journals Angiotensin II Stimulates Endothelial NO Synthase Phosphorylation in Thoracic Aorta of Mice With Abdominal Aortic Banding Via Type 2 Receptor

Hypertension ◽  
2006 ◽  
Vol 48 (5) ◽  
pp. 958-964 ◽  
Author(s):  
Katsutoshi Yayama ◽  
Hiromi Hiyoshi ◽  
Daichi Imazu ◽  
Hiroshi Okamoto
Keyword(s):  
Angiotensin Ii ◽  
Thoracic Aorta ◽  
No Synthase ◽  
Aortic Banding ◽  
Endothelial No Synthase ◽  
Abdominal Aortic

scholarly journals Androgen-Androgen Receptor System Protects against Angiotensin II-Induced Vascular Remodeling

Endocrinology ◽  
2009 ◽  
Vol 150 (6) ◽  
pp. 2857-2864 ◽  
Author(s):  
Yasumasa Ikeda ◽  
Ken-ichi Aihara ◽  
Sumiko Yoshida ◽  
Takashi Sato ◽  
Shusuke Yagi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Androgen Receptor ◽  
Angiotensin Ii ◽  
Vascular Remodeling ◽  
Collagen Type ◽  
No Synthase ◽  
Type I ◽  
Ang Ii ◽  
Endothelial No Synthase ◽  
No Bioavailability

Age-related andropause promotes cardiovascular disease in males. Although we had previously reported that the androgen-androgen receptor (AR) system plays important roles in cardiac growth and remodeling, the system’s involvement in vascular remodeling remains unclear. To clarify this role, 25-wk-old male AR knockout (ARKO) mice and littermate male wild-type (WT) mice were divided into two groups with and without angiotensin II (Ang II) administration (2.0 mg/kg · d) for 14 d, respectively. No morphological differences in the coronary artery and thoracic aorta were observed between the groups without Ang II. Ang II stimulation markedly increased medial thickness and perivascular fibrosis in ARKO mice, with enhanced TGF-β1, collagen type I, and collagen type III gene expression in the aorta. Ang II stimulation also prominently increased superoxide production, lipid peroxidation, and gene expression of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase components in ARKO mice compared with WT mice. In addition, phosphorylation of c-Jun N-terminal kinase (JNK) and phosphorylated (Smad2/3) was remarkably enhanced in Ang II-treated ARKO mice compared with Ang II-treated WT mice. Notably, daily urinary nitric oxide (NO) metabolites excretion as a marker of NO bioavailability, aortic endothelial NO synthase expression and phosphorylation, and Akt phosphorylation were significantly reduced in ARKO mice compared with WT mice, regardless of Ang II stimulation. In conclusion, the androgen-AR system is required for the preservation of NO bioavailability through Akt-endothelial NO synthase system activation and exerts protective effects against Ang II-induced vascular remodeling by regulating oxidative stress, c-Jun N-terminal kinase (JNK) signaling, and the TGF-β-phosphorylated Smad pathway.

scholarly journals Inhibitory Effect of Angiotensin II Type 2 Receptor on Coronary Arterial Remodeling After Aortic Banding in Mice

Circulation ◽  
2000 ◽  
Vol 102 (14) ◽  
pp. 1684-1689 ◽  
Author(s):  
Masahiro Akishita ◽  
Masaru Iwai ◽  
Lan Wu ◽  
Lunan Zhang ◽  
Yasuyoshi Ouchi ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Inhibitory Effect ◽  
Arterial Remodeling ◽  
Aortic Banding

scholarly journals Effect of ACE Inhibitors and Angiotensin II Type 1 Receptor Antagonists on Endothelial NO Synthase Knockout Mice With Heart Failure

Hypertension ◽  
2002 ◽  
Vol 39 (2) ◽  
pp. 375-381 ◽  
Author(s):  
Yun-He Liu ◽  
Jiang Xu ◽  
Xiao-Ping Yang ◽  
Fang Yang ◽  
Edward Shesely ◽  
...  
Keyword(s):  
Heart Failure ◽  
Angiotensin Ii ◽  
Ace Inhibitors ◽  
Knockout Mice ◽  
No Synthase ◽  
Receptor Antagonists ◽  
Endothelial No Synthase

Up-Regulation of Angiotensin II Type 2 Receptor in Rat Thoracic Aorta by Pressure-Overload

2003 ◽  
Vol 308 (2) ◽  
pp. 736-743 ◽  
Author(s):  
Katsutoshi Yayama ◽  
Miyuki Horii ◽  
Hiromi Hiyoshi ◽  
Masaoki Takano ◽  
Hiroshi Okamoto ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Thoracic Aorta ◽  
Pressure Overload ◽  
Rat Thoracic Aorta

scholarly journals The effect of oral contraceptives on the nitric oxide system and renal function

2007 ◽  
Vol 293 (5) ◽  
pp. F1539-F1544 ◽  
Author(s):  
D. Z. I. Cherney ◽  
J. W. Scholey ◽  
D. C. Cattran ◽  
A. K. Kang ◽  
J. Zimpelmann ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Function ◽  
Angiotensin Ii ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
No Synthase ◽  
Receptor Expression ◽  
Arginine Infusion ◽  
Endothelial No Synthase ◽  
Ras Activation

We have demonstrated that oral contraceptive (OC) users exhibit elevated angiotensin II levels and angiotensin II type 1 receptor expression, indicative of renin-angiotensin system (RAS) activation, yet the renal and systemic consequences are minimal, suggesting that there is increased vasodilatory activity, counteracting the effect of RAS activation. We hypothesized that the nitric oxide (NO) system would be upregulated in OC users and that this would be reflected by a blunted hemodynamic response to l-arginine infusion. All subjects were studied after a 7-day controlled sodium and protein diet. Inulin and para-aminohippurate clearance techniques were used to assess renal function. l-Arginine was infused at 100, 250, and 500 mg/kg, each over 30 min. Skin endothelial NO synthase mRNA expression was assessed by real-time PCR. While OC nonusers exhibited significant increases in effective renal plasma flow (670.8 ± 35.6 to 816.2 ± 59.7 ml·min−1·1.73 m−2) and glomerular filtration rate (133.4 ± 4.3 to 151.0 ± 5.7 ml·min−1·1.73 m−2, P = 0.04) and declines in renal vascular resistance (81.1 ± 6.1 to 63.5 ± 6.2 mmHg·ml−1·min, P = 0.001) at the lower l-arginine infusion rates, the responses in OC users were blunted. While l-arginine reduced mean arterial pressure at the 250 and 500 mg/kg doses in OC nonusers, OC users only exhibited a decrease in mean arterial pressure at the highest infusion rate. In contrast, tissue endothelial NO synthase mRNA levels were higher in the OC users ( P = 0.04). In summary, these findings suggest that the NO system is upregulated by OC use in young, healthy women. Increased activity of the NO pathway may modulate the hemodynamic effects of RAS activation in OC users.

scholarly journals Specificity of blood pressure numbers in Holter monitoring depending on gene polymorphism among residents of Ternopil region afflicted with essential arterial hypertension

2021 ◽  
Vol 11 (7) ◽  
pp. 124-134
Author(s):  
Roman Volodymyrovych Hnizdyukh ◽  
Volodymyr Vasylovych Shmanko
Keyword(s):  
Blood Pressure ◽  
Angiotensin Ii ◽  
Arterial Hypertension ◽  
Holter Monitoring ◽  
No Synthase ◽  
Control Group ◽  
Enos Gene ◽  
Type I ◽  
Angiotensin Ii Receptor ◽  
Endothelial No Synthase

The aim of this work is to determine specificities of blood pressure (BP) numbers during the day depending on polymorphism of the A1166C-gene of angiotensin II receptor type I and T786C-promoter of the endothelial NO-synthase gene among residents of Ternopil region afflicted with essential arterial hypertension.We have examined 86 patients with arterial hypertension who were treated and examined in the therapeutic department of the Central District Hospital in Kozova, aged from 45 to 76 years. All patients were measured for body weight and height, office blood pressure; also they were checked by Holter monitoring and electrocardiography (ECG), as well as examined for polymorphism of endothelial NO synthase genes and angiotensin II type 1 receptor genes. Statistical processing of the obtained data was performed with the help of the analytics software package including Statistica 8.0 (StatSoft Inc., USA) and Microsoft Office Excel-2003.The research revealed that patients with CC genotype A1166C-gene of angiotensin II receptor of the first type had a significantly higher level of systolic blood pressure (SBP) and diastolic blood pressure (DBP) – average numbers per 24 hours, day and night – compared to patients with genotype AA(p<0,05). Hereby, no significant distinctions in blood pressure variability were found.Patients with CC of the T786C promoter of the eNOs gene had higher SBP and DBP values at all times of the day compared to individuals with the TT genotype (p <0.05). Increased levels of variability of DBP during the day, as well as SBP and DBP at night, were observed among patients with CC genotype, as compared with the control group (p <0.05).Among patients with C-allele of both studied genes, there’s a high frequency of circadian rhythm disorders with predominance of the “non-dippers” pathological type.

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