scholarly journals Influence of Female Sex Hormones on Endothelium-Derived Vasoconstrictor Prostanoid Generation in Microvessels of Spontaneously Hypertensive Rats

Hypertension ◽  
1999 ◽  
Vol 34 (4) ◽  
pp. 914-919 ◽  
Author(s):  
Ana Paula V. Dantas ◽  
Regina Scivoletto ◽  
Zuleica B. Fortes ◽  
Dorothy Nigro ◽  
Maria Helena C. Carvalho
Keyword(s):  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Female Sex ◽  
Female Sex Hormones

scholarly journals Female sex hormones protect against salt-sensitive hypertension but not essential hypertension

2014 ◽  
Vol 307 (2) ◽  
pp. R149-R157 ◽  
Author(s):  
Krystal N. Brinson ◽  
Olga Rafikova ◽  
Jennifer C. Sullivan
Keyword(s):  
Protein Expression ◽  
Sex Hormones ◽  
Serine Residue ◽  
Relative Resistance ◽  
Salt Diet ◽  
Spontaneously Hypertensive ◽  
Female Sex ◽  
Female Sex Hormones ◽  
Oxide Synthase ◽  
Salt Sensitive Hypertension

Initial studies found that female Dahl salt-sensitive (DS) rats exhibit greater blood pressure (BP) salt sensitivity than female spontaneously hypertensive rats (SHR). On the basis of the central role played by NO in sodium excretion and BP control, we further tested the hypothesis that blunted increases in BP in female SHR will be accompanied by greater increases in renal inner medullary nitric oxide synthase (NOS) activity and expression in response to a high-salt (HS) diet compared with DS rats. Gonad-intact and ovariectomized (OVX) female SHR and DS rats were placed on normal salt (NS; 0.4% salt) or HS (4% salt) diet for 2 wk. OVX did not alter BP in SHR, and HS diet produced a modest increase in BP. OVX significantly increased BP in DS rats on NS; HS further increased BP in all DS rats, although OVX had a greater increase in BP. Renal inner medullary NOS activity, total NOS3 protein, and NOS3 phosphorylated on serine residue 1177 were not altered by salt or OVX in either strain. NOS1 protein expression, however, significantly increased with HS only in SHR, and this corresponded to an increase in urinary nitrate/nitrite excretion. SHR also exhibit greater NOS1 and NOS3 protein expression than DS rats. These data indicate that female sex hormones offer protection against HS-mediated elevations in BP in DS rats but not SHR. We propose that the relative resistance to HS-mediated increases in BP in SHR is related to greater NOS expression and the ability to increase NOS1 protein expression compared with DS rats.

scholarly journals STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats

2011 ◽  
Vol 122 (5) ◽  
pp. 215-226 ◽  
Author(s):  
Fernanda R. C. Giachini ◽  
Victor V. Lima ◽  
Fernando P. Filgueira ◽  
Anne M. Dorrance ◽  
Maria Helena C. Carvalho ◽  
...  
Keyword(s):  
Sex Differences ◽  
Neutralizing Antibodies ◽  
Spontaneously Hypertensive Rats ◽  
Female Rats ◽  
Hypertensive Rats ◽  
Vascular Protection ◽  
Spontaneously Hypertensive ◽  
Female Sex Hormones ◽  
Impaired Control ◽  
Wistar Kyoto

Sex differences in Ca2+-dependent signalling and homoeostasis in the vasculature of hypertensive rats are well characterized. However, sex-related differences in SOCE (store-operated Ca2+ entry) have been minimally investigated. We hypothesized that vascular protection in females, compared with males, reflects decreased Ca2+ mobilization due to diminished activation of Orai1/STIM1 (stromal interaction molecule 1). In addition, we investigated whether ovariectomy in females affects the activation of the Orai1/STIM1 pathway. Endothelium-denuded aortic rings from male and female SHRSP (stroke-prone spontaneously hypertensive rats) and WKY (Wistar–Kyoto) rats and from OVX (ovariectomized) or sham female SHRSP and WKY rats were used to functionally evaluate Ca2+ influx-induced contractions. Compared with females, aorta from male SHRSP displayed: (i) increased contraction during the Ca2+-loading period; (ii) similar transient contraction during Ca2+ release from the intracellular stores; (iii) increased activation of STIM1 and Orai1, as shown by the blockade of STIM1 and Orai1 with neutralizing antibodies, which reversed the sex differences in contraction during the Ca2+-loading period; and (iv) increased expression of STIM1 and Orai1. Additionally, we found that aortas from OVX-SHRSP showed increased contraction during the Ca2+-loading period and increased Orai1 expression, but no changes in the SR (sarcoplasmic reticulum)-buffering capacity or STIM1 expression. These findings suggest that augmented activation of STIM1/Orai1 in aortas from male SHRSP represents a mechanism that contributes to sex-related impaired control of intracellular Ca2+ levels. Furthermore, female sex hormones may negatively modulate the STIM/Orai1 pathway, contributing to vascular protection observed in female rats.

scholarly journals Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0127515 ◽  
Author(s):  
P. L. M. Dalpiaz ◽  
A. Z. Lamas ◽  
I. F. Caliman ◽  
R. F. Ribeiro ◽  
G. R. Abreu ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Contractility ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals Effects of sex hormones on associative learning in spontaneously hypertensive rats

2008 ◽  
Vol 93 (3) ◽  
pp. 651-657 ◽  
Author(s):  
David J. Bucci ◽  
Michael E. Hopkins ◽  
Antonio A. Nunez ◽  
S. Marc Breedlove ◽  
Cheryl L. Sisk ◽  
...  
Keyword(s):  
Associative Learning ◽  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

scholarly journals EFFECTS OF VALSARTAN AND BENAZAPRIL ON SERUM SEX HORMONES, GONADO-SOMATIC INDEX AND ERECTION FUNCTION IN SPONTANEOUSLY HYPERTENSIVE RATS

Heart ◽  
2012 ◽  
Vol 98 (Suppl 2) ◽  
pp. E122.1-E122
Author(s):  
Liu Huangjun ◽  
Liu Xueyin ◽  
Liu Zhenlan ◽  
Fan Wen ◽  
Zhang Jiajun ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Somatic Index

scholarly journals Correction: Sex Hormones Promote Opposite Effects on ACE and ACE2 Activity, Hypertrophy and Cardiac Contractility in Spontaneously Hypertensive Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0133225 ◽  
Author(s):  
EP. L. M. Dalpiaz ◽  
A. Z. Lamas ◽  
I. F. Caliman ◽  
R. F. Ribeiro ◽  
G. R. Abreu ◽  
...  
Keyword(s):  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Cardiac Contractility ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Sex and sex hormones influence the development of albuminuria and renal macrophage infiltration in spontaneously hypertensive rats

2007 ◽  
Vol 293 (4) ◽  
pp. R1573-R1579 ◽  
Author(s):  
Jennifer C. Sullivan ◽  
Laura Semprun-Prieto ◽  
Erika I. Boesen ◽  
David M. Pollock ◽  
Jennifer S. Pollock
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Sex Hormones ◽  
Spontaneously Hypertensive Rats ◽  
Macrophage Infiltration ◽  
Ang Ii ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Blood Pressures ◽  
Over Time

There is a sex difference in hypertensive renal injury, with men experiencing greater severity and a more rapid progression of renal disease than women; however, the molecular mechanisms protecting against renal injury in women are unknown. The goal of this study was to determine whether sex hormones modulate blood pressure and the progression of albuminuria during the developmental phase of hypertension in male and female spontaneously hypertensive rats (SHR). Studies were also performed to examine how sex and sex hormones influence two major risk factors for albuminuria, overactivation of the renin-angiotensin system and oxidative stress. Blood pressure was measured by telemetry in gonad-intact and gonadectomized male and female SHR. Microalbumin excretion, measured over time, and macrophage infiltration were used to assess renal health. Male SHR had significantly higher blood pressures than female SHR, and gonadectomy decreased blood pressures in males with no effect in females. Male SHR displayed a gonad-sensitive increase in albuminuria over time, and female SHR had a gonad-sensitive suppression in macrophage infiltration. Female SHR had greater plasma ANG II levels and similar levels of renal cortical ANG II vs. levels shown in males but less AT1-receptor protein expression in the renal cortex. Female SHR also had a gonad-sensitive decrease in renal oxidative stress. Therefore, the renal protection afforded to female SHR is associated with lower blood pressure, decreased macrophage infiltration, and decreased levels of oxidative stress.

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