scholarly journals Association Between a Functional Variant of the KLOTHO Gene and High-Density Lipoprotein Cholesterol, Blood Pressure, Stroke, and Longevity

2005 ◽  
Vol 96 (4) ◽  
pp. 412-418 ◽  
Author(s):  
Dan E. Arking ◽  
Gil Atzmon ◽  
Albert Arking ◽  
Nir Barzilai ◽  
Harry C. Dietz
Keyword(s):  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Klotho Gene ◽  
Functional Variant

Association of Physical Activity and Cardiometabolic Risk in Children 3–12 Years

2020 ◽  
Vol 17 (8) ◽  
pp. 800-806
Author(s):  
Leigh M. Vanderloo ◽  
Jonathan L. Maguire ◽  
David W. H. Dai ◽  
Patricia C. Parkin ◽  
Cornelia M. Borkhoff ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
Systolic Blood Pressure ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Height Ratio ◽  
Waist To Height Ratio

Background: This study aimed to examine the association between physical activity (PA) and a total cardio metabolic risk (CMR) score in children aged 3–12 years. Secondary objectives were to examine the association between PA and individual CMR factors. Methods: A longitudinal study with repeated measures was conducted with participants from a large primary care practice-based research network in Toronto, Canada. Mixed effects models were used to examine the relationship between parent-reported physical activity and outcome variables (total CMR score, triglycerides, glucose, high-density lipoprotein cholesterol, systolic blood pressure, waist circumference, weight-to-height ratio, and non-high-density lipoprotein cholesterol). Results: Data from 1885 children (6.06 y, 54.4% male) with multiple visits (n = 2670) were included in the analyses. For every unit increase of 60 minutes of PA, there was no evidence of an association with total CMR score (adjusted: −0.02 [−0.014 to 0.004], P = .11]. For the individual CMR components, there was evidence of a weak association between PA and systolic blood pressure (−0.01 [−0.03 to −0.01], P < .001) and waist-to-height ratio (−0.81 [−1.62 to −0.003], P < .001). Conclusion: Parent-reported PA among children aged 3–12 years was not statistically associated with total CMR, but was weakly associated with systolic blood pressure and waist-to-height ratio.

COMPARITIVE STUDY OF HDL-C LEVEL IN DIABETIC AND NONDIABETIC STROKE SUBJECTS

1969 ◽  
Vol 6 (2) ◽  
pp. 816-820
Author(s):  
SAHIBZADA SAEED JAN ◽  
AMIN JAN ◽  
JAN.I.ALAM ◽  
TAJ MUHAMMAD KHAN
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Stroke Patients ◽  
History Of

BACKGROUND: Diabetes mellitus is a well recognized risk factor for acute stroke, resulting in agreater ischemic to hemorrhagic stroke ratio in the people with diabetes compared with the generalpopulation. Diabetes also doubles the risk of stroke recurrence and has a poor outcome (or having poorprognosis for survival) as compared to non-diabetic patients, warranting strong and comprehensivepreventive efforts, The aim of this study was to evaluate the High Density Lipoprotein-Cholesterol(HDL-C) level in the adult diabetic and non-diabetic stroke patients coming to Medical Unit of SaiduTeaching Hospital, Swat.MATERIAL AND METHODOLOGY: This was a cross-sectional study, comprised of 100 subjects,50 were diabetic and 50 were non -diabetic stroke patients of ages between 40 to 90 years. The studysubjects underwent a detailed history and examination. Individuals with a history of medications knownto affects body composition, patients on anti-coagulants and having a history of blood dyscrasias likeleukemia’s, thalasemia, polycythemia, endocrinopathies and patients having clotting disorders, extraduraland intradural hemorrhage as a cause of stroke were excluded from the study. Fasting as well as randomblood sample were drawn from the participants for biochemical assays. The serum HDL-C level, bloodsugar (random and fasting), blood pressure (systolic and diastolic) of Diabetic stroke subjects werecompared with Non-diabetic stroke subjects.RESULTS: The HDL-C level was significantly low in our study in diabetic as compared to nondiabetic stroke subjects.CONCLUSION: The low HDL-C level along with poor metabolic control is an important risk factorfor chronic complications of diabetes mellitus like microvascular and macrovascular disease likeunstable angina, myocardial infarction and stroke. Therefore there is intense need of early screening andinterventions, to prevent macrovascular complications especially stroke in high risk diabetic patients.KEY WORDS: Diabetes mellitus, High-density Lipoprotein-Cholesterol (HDL-C), Blood pressure,Stroke.

A COMPARATIVE STUDY OF LIPID PROFILE AND LEPTIN RESISTANCE IN CHILDREN WITH METABOLIC SYNDROME DEPENDING ON HYPERTENSION IN KYIV

2021 ◽  
Vol 74 (10) ◽  
pp. 2630-2633
Author(s):  
Maiia H. Aliusef ◽  
Alina V. Churylina ◽  
Ganna V. Gnyloskurenko ◽  
Inga O. Mitiuriaeva ◽  
Vitaliy G. Maidannyk
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Leptin Resistance ◽  
Normal Blood Pressure

The aim: To compare lipid metabolism and leptin levels among the children with and without hypertension to identify associated risk factors for the course of metabolic syndrome in children. Materials and methods: This observational, cross-sectional study recruited children from the Rheumocardiology Department of Children’s Clinical Hospital No 6 in Kyiv, with metabolic syndrome, identification of waist-to-height ratio, leptin level, homeostasis model assessment of insulin resistance and lipid profile. The main group included 41 children with metabolic syndrome and hypertension and the control group included 40 children with metabolic syndrome without hypertension. Statistical data analysis was performed using the MedStat 2.6.2. package. Results: A total of 81 children aged 10 to 17 with metabolic syndrome were examined. The group of children with hypertension had significantly lower high-density lipoprotein cholesterol (0.85±0.04) than children without hypertension (0.94±0.03), with p < 0.05. Leptin resistance was detected in 65.2% of children with hypertension and 35.3% of children with normal blood pressure (p < 0.01). Conclusions: Children with metabolic syndrome and hypertension had a significantly higher body mass index and waist circumference as opposed to children with normal blood pressure. In the lipid profile high-density lipoprotein cholesterol was significantly lower in hypertensive children. There was no reliable difference in other lipid profile indicators between the two groups, but there was an upward trend of them in group with hypertension. Leptin resistance is also significantly higher in hypertensive children.

Sign in / Sign up

Export Citation Format

Share Document