scholarly journals A Zebrafish Model of Human Barth Syndrome Reveals the Essential Role of Tafazzin in Cardiac Development and Function

2006 ◽  
Vol 99 (2) ◽  
pp. 201-208 ◽  
Author(s):  
Zaza Khuchua ◽  
Zou Yue ◽  
Lorene Batts ◽  
Arnold W. Strauss
Keyword(s):  
Essential Role ◽  
Cardiac Development ◽  
Barth Syndrome ◽  
Zebrafish Model ◽  
And Function

scholarly journals Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

PLoS Biology ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. e3001444
Author(s):  
Nina L. Kikel-Coury ◽  
Jacob P. Brandt ◽  
Isabel A. Correia ◽  
Michael R. O’Dea ◽  
Dana F. DeSantis ◽  
...  
Keyword(s):  
Heart Rate ◽  
Nervous System ◽  
Cardiac Development ◽  
Time Lapse ◽  
Zebrafish Model ◽  
Single Cell Sequencing ◽  
Parasympathetic System ◽  
And Function ◽  
Time Lapse Imaging

Glial cells are essential for functionality of the nervous system. Growing evidence underscores the importance of astrocytes; however, analogous astroglia in peripheral organs are poorly understood. Using confocal time-lapse imaging, fate mapping, and mutant genesis in a zebrafish model, we identify a neural crest–derived glial cell, termed nexus glia, which utilizes Meteorin signaling via Jak/Stat3 to drive differentiation and regulate heart rate and rhythm. Nexus glia are labeled with gfap, glast, and glutamine synthetase, markers that typically denote astroglia cells. Further, analysis of single-cell sequencing datasets of human and murine hearts across ages reveals astrocyte-like cells, which we confirm through a multispecies approach. We show that cardiac nexus glia at the outflow tract are critical regulators of both the sympathetic and parasympathetic system. These data establish the crucial role of glia on cardiac homeostasis and provide a description of nexus glia in the PNS.

scholarly journals Essential role of  -adrenergic receptor kinase 1 in cardiac development and function

1996 ◽  
Vol 93 (23) ◽  
pp. 12974-12979 ◽  
Author(s):  
M. Jaber ◽  
W. J. Koch ◽  
H. Rockman ◽  
B. Smith ◽  
R. A. Bond ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Essential Role ◽  
Cardiac Development ◽  
Receptor Kinase ◽  
And Function

scholarly journals Essential Role of Septin 7 in Skeletal Muscle Structure and Function

2020 ◽  
Vol 118 (3) ◽  
pp. 258a
Author(s):  
Laszlo Csernoch ◽  
Mónika Gönczi ◽  
Zsolt Ráduly ◽  
László Szabó ◽  
Nóra Dobrosi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Essential Role ◽  
Structure And Function ◽  
Muscle Structure ◽  
And Function

Essential role of Hand2 in interventricular septum formation and trabeculation during cardiac development

2006 ◽  
Vol 343 (1) ◽  
pp. 144-151 ◽  
Author(s):  
Kiyonori Togi ◽  
Yoshinori Yoshida ◽  
Hironobu Matsumae ◽  
Yasuhiro Nakashima ◽  
Toru Kita ◽  
...  
Keyword(s):  
Essential Role ◽  
Cardiac Development ◽  
Interventricular Septum ◽  
Septum Formation

scholarly journals Essential role of BRCA2 in ovarian development and function

2019 ◽  
Author(s):  
Weinberg-Shukron A ◽  
Rachmiel M ◽  
Renbaum P ◽  
Gulsuner S ◽  
Walsh T ◽  
...  
Keyword(s):  
Essential Role ◽  
Ovarian Development ◽  
And Function

scholarly journals Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

2000 ◽  
Vol 165 (4) ◽  
pp. 1738-1742 ◽  
Author(s):  
Ari Hashimoto ◽  
Kiyoshi Takeda ◽  
Muneo Inaba ◽  
Masayuki Sekimata ◽  
Tsuneyasu Kaisho ◽  
...  
Keyword(s):  
B Cell ◽  
Phospholipase C ◽  
Essential Role ◽  
Cell Development ◽  
B Cell Development ◽  
Cutting Edge ◽  
And Function

scholarly journals Role of Tafazzin in Mitochondrial Function, Development and Disease

2020 ◽  
Vol 8 (2) ◽  
pp. 10
Author(s):  
Michael T. Chin ◽  
Simon J. Conway
Keyword(s):  
Mitochondrial Function ◽  
Human Disease ◽  
Cardiac Development ◽  
Barth Syndrome ◽  
Therapeutic Modality ◽  
Model Organisms ◽  
Adult Disease ◽  
Functional Studies ◽  
Multiple Species

Tafazzin, an enzyme associated with the rare inherited x-linked disorder Barth Syndrome, is a nuclear encoded mitochondrial transacylase that is highly conserved across multiple species and plays an important role in mitochondrial function. Numerous studies have elucidated the mechanisms by which Tafazzin affects mitochondrial function, but its effects on development and susceptibility to adult disease are incompletely understood. The purpose of this review is to highlight previous functional studies across a variety of model organisms, introduce recent studies that show an important role in development, and also to provide an update on the role of Tafazzin in human disease. The profound effects of Tafazzin on cardiac development and adult cardiac homeostasis will be emphasized. These studies underscore the importance of mitochondrial function in cardiac development and disease, and also introduce the concept of Tafazzin as a potential therapeutic modality.

Understanding the relationship between the microbiome and the structure and function of the pig gastrointestinal tract

2022 ◽  
pp. 165-178
Author(s):  
Chunlong Mu ◽  
◽  
Weiyun Zhu ◽  
Keyword(s):  
Gut Microbiome ◽  
Amino Acid Metabolism ◽  
Essential Role ◽  
Short Chain Fatty Acids ◽  
Structure And Function ◽  
Host Interaction ◽  
Epithelial Structure ◽  
And Function ◽  
The Relationship

The gut epithelium acts as a barrier to the gut environment. The integrity of the epithelial structure and function is thus critical for microbiome-host interaction. The gut microbiome can regulate the utilization and synthesis of mucin, the expressions of the intercellular junction complex, and the functioning of specific epithelial cells, such as enterochromaffin cells and stem cells in pigs. The factors involved include microbial metabolites, especially short-chain fatty acids and host-microbe co-metabolism. Recent studies have revealed the essential role of amino acid metabolism in regulating the gut microbiome and epithelial barrier. This chapter discusses how the pig gut microbiome modulates epithelial structure and function, highlighting findings that reflect the relationship between the gut microbiome, intestinal structure and function.

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