scholarly journals Proliferating cell nuclear antigen in developing and adult rat cardiac muscle cells.

1991 ◽  
Vol 69 (5) ◽  
pp. 1353-1360 ◽  
Author(s):  
T A Marino ◽  
S Haldar ◽  
E C Williamson ◽  
K Beaverson ◽  
R A Walter ◽  
...  
Keyword(s):  
Cardiac Muscle ◽  
Proliferating Cell Nuclear Antigen ◽  
Muscle Cells ◽  
Nuclear Antigen ◽  
Cardiac Muscle Cells ◽  
Adult Rat ◽  
Proliferating Cell

scholarly journals Comparison of streptozotocin-induced diabetic and insulin resistant effects on spermatogenesis with proliferating cell nuclear antigen (PCNA) immunostaining of adult rat testis

2012 ◽  
Vol 29 (3) ◽  
pp. 209-214 ◽  
Author(s):  
Adesina Paul Arikawe ◽  
Adetola Olubunmi Daramola ◽  
Ifeoma Christianah Udenze ◽  
Muyiwa Francis Akinwolere ◽  
Ibiyemi Ibitola Olatunji-Bello ◽  
...  
Keyword(s):  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Rat Testis ◽  
Insulin Resistant ◽  
Adult Rat ◽  
Proliferating Cell

scholarly journals Ellagic acid suppresses oxidised low-density lipoprotein-induced aortic smooth muscle cell proliferation: studies on the activation of extracellular signal-regulated kinase 1/2 and proliferating cell nuclear antigen expression

2008 ◽  
Vol 99 (4) ◽  
pp. 709-714 ◽  
Author(s):  
Weng-Cheng Chang ◽  
Ya-Mei Yu ◽  
Su-Yin Chiang ◽  
Chiung-Yao Tseng
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Ellagic Acid ◽  
Proliferating Cell Nuclear Antigen ◽  
Muscle Cells ◽  
Nuclear Antigen ◽  
Aortic Smooth Muscle ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Proliferating Cell

Proliferation of intimal vascular smooth muscle cells is an important component in the development of atherosclerosis. Ellagic acid is a phenolic compound present in fruits (raspberries, blueberries, strawberries) and walnuts. The present study investigated the effect of ellagic acid on the oxidised LDL (ox-LDL)-induced proliferation of rat aortic smooth muscle cells (RASMC). The study found that ellagic acid significantly inhibited ox-LDL-induced proliferation of RASMC and phosphorylation of extracellular signal-regulated kinase (ERK) 1/2.Furthermore, ellagic acid also blocked the ox-LDL-induced (inducible) cell-cycle progression and down regulation of the expression of proliferating cell nuclear antigen (PCNA) in RASMC. Therefore, ellagic acid reduced the amount of ox-LDL-induced proliferation of RASMC via inactivation of the ERK pathway and suppression of PCNA expression. These results may significantly advance the understanding of the role that antioxidants play in the prevention of atherosclerosis.

scholarly journals Preproenkephalin mRNA expression in developing rat heart and in cultured ventricular cardiac muscle cells

1989 ◽  
Vol 258 (1) ◽  
pp. 73-78 ◽  
Author(s):  
J P Springhorn ◽  
W C Claycomb
Keyword(s):  
Cardiac Muscle ◽  
Cell Cultures ◽  
Translational Regulation ◽  
Muscle Cells ◽  
Heart Cell ◽  
Developmentally Regulated ◽  
Adult Rats ◽  
Cardiac Muscle Cells ◽  
Adult Rat ◽  
Developing Rat

Heart muscle tissue has previously been reported to have the highest content of preproenkephalin (ppEnk) mRNA of any tissue in the adult rat. We have determined that it is present in the ventricular cardiac muscle cells of the heart and is developmentally regulated. The expression of ppEnk mRNA was observed to be low throughout the first 2 weeks of postnatal development and decreases substantially during week 3. Expression was again low by week 4, but by adulthood (approx. 3 months), it reached a maximum. ppEnk mRNA was actively expressed in primary cardiac muscle cell cultures prepared from both neonatal and adult rats. Its steady-state content in cell cultures was observed to be increased by cyclic AMP and 3-isobutyl-1-methylxanthine. The phorbol ester phorbol 12-myristate 13-acetate elicited a transient effect (i.e. an increase was observed at 4 h and a return to control values by 24 h). We speculate that enkephalin may play a multi-functional role in the differentiation of neonatal cardiac muscle cells and in the terminally differentiated adult heart cell. We demonstrate that the primary culture systems employed in this study will be useful models with which to explore both transcriptional and translational regulation of ppEnk mRNA in the heart.

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