scholarly journals Continuous Quantitative EEG Monitoring in Hemispheric Stroke Patients Using the Brain Symmetry Index

Stroke ◽  
2004 ◽  
Vol 35 (11) ◽  
pp. 2489-2492 ◽  
Author(s):  
Michel J.A.M. van Putten ◽  
Dénes L.J. Tavy
2008 ◽  
Vol 25 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Cecile C. de Vos ◽  
Susan M. van Maarseveen ◽  
Paul J. A. M. Brouwers ◽  
Michel J. A. M. van Putten

2012 ◽  
Vol 23 (3) ◽  
pp. 247-253 ◽  
Author(s):  
Jurriaan M. Peters ◽  
Meritxell Tomas-Fernandez ◽  
Michel J.A.M. van Putten ◽  
Tobias Loddenkemper

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P04.029-P04.029
Author(s):  
M. Tomas-Fernandez ◽  
T. Loddenkemper ◽  
M. Van Putten ◽  
J. Peters

2018 ◽  
Vol 3 (5) ◽  
pp. 247-253
Author(s):  
D. A. Potii ◽  
◽  
S. V. Tatarko ◽  
A. H. Snegir ◽  
G. A. Prokopenko ◽  
...  

2021 ◽  
Vol 11 (7) ◽  
pp. 2987
Author(s):  
Takumi Okumura ◽  
Yuichi Kurita

Image therapy, which creates illusions with a mirror and a head mount display, assists movement relearning in stroke patients. Mirror therapy presents the movement of the unaffected limb in a mirror, creating the illusion of movement of the affected limb. As the visual information of images cannot create a fully immersive experience, we propose a cross-modal strategy that supplements the image with sensual information. By interacting with the stimuli received from multiple sensory organs, the brain complements missing senses, and the patient experiences a different sense of motion. Our system generates the sense of stair-climbing in a subject walking on a level floor. The force sensation is presented by a pneumatic gel muscle (PGM). Based on motion analysis in a human lower-limb model and the characteristics of the force exerted by the PGM, we set the appropriate air pressure of the PGM. The effectiveness of the proposed system was evaluated by surface electromyography and a questionnaire. The experimental results showed that by synchronizing the force sensation with visual information, we could match the motor and perceived sensations at the muscle-activity level, enhancing the sense of stair-climbing. The experimental results showed that the visual condition significantly improved the illusion intensity during stair-climbing.


Stroke ◽  
2016 ◽  
Vol 47 (suppl_1) ◽  
Author(s):  
Hetal Mistry ◽  
Madeline Levy ◽  
Meaghan Roy-O'Reilly ◽  
Louise McCullough

Background and Purpose: Orosomucoid-1 (ORM-1) is an abundant protein with important roles in inflammation and immunosuppression. We utilized RNA sequencing to measure mRNA levels in human ischemic stroke patients, with confirmation by serum ORM-1 protein measurements. A mouse model of ischemic stroke was then used to examine post-stroke changes in ORM-1 within the brain itself. Hypothesis: We tested the hypothesis that ORM-1 levels increase following ischemic stroke, with sex differences in protein dynamics over time. Methods: RNA sequencing was performed on whole blood from ischemic stroke patients (n=23) and controls (n=12), with Benjamini-Hochberg correction for multiple testing. Enzyme-linked immunosorbent assay was performed on serum from ischemic stroke patients (n=28) and controls (n=8), with analysis by T-test. For brain analysis, mice (n=14) were subjected to a 90-minute middle cerebral artery occlusion (MCAO) surgery and sacrificed 6 or 24 hours after stroke. Control mice underwent parallel “sham” surgery without occlusion. Western blotting was used to detect ORM-1 protein levels in whole brain, with analysis by two-way ANOVA. Results: RNA sequencing showed a 2.8-fold increase in human ORM-1 at 24 hours post-stroke (q=.0029), an increase also seen in serum ORM-1 protein levels (p=.011). Western blot analysis of mouse brain revealed that glycosylated (p=0.0003) and naive (p=0.0333) forms of ORM-1 were higher in female mice compared to males 6 hours post-stroke. Interestingly, ORM-1 levels were higher in the brains of stroke mice at 6 hours (p=.0483), while at 24 hours ORM-1 levels in stroke mice were lower than their sham counterparts (p=.0212). In both human and mouse data, no sex differences were seen in ORM-1 levels in the brain or periphery at 24 hours post-stroke. Conclusion: In conclusion, ORM-1 is a sexually dimorphic protein involved in the early (<24 hour) response to ischemic stroke. This research serves as an initial step in determining the mechanism of ORM-1 in the ischemic stroke response and its potential as a future therapeutic target for both sexes.


1991 ◽  
Vol 78 (5) ◽  
pp. 325-332 ◽  
Author(s):  
Douglas R. Labar ◽  
Bruce J. Fisch ◽  
Timothy A. Pedley ◽  
Matthew E. Fink ◽  
Robert A. Solomon

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