Abstract P236: The Heritability of Submaximal Exercise Heart Rate Response to Regular Exercise is Accounted for by Nine SNPs

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Tuomo Rankinen ◽  
Yun Ju Sung ◽  
Mark Sarzynski ◽  
Treva K Rice ◽  
DC Rao ◽  
...  
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Endurance Training ◽  
Heart Rate Response ◽  
Family Study ◽  
Significant Snps ◽  
Submaximal Exercise ◽  
Regular Physical Activity ◽  
Physical Work ◽  
Exercise Heart Rate

Regular physical activity is the most effective non-pharmacological strategy to lower heart rate both at rest and during submaximal physical work. We have previously shown that endurance training-induced changes in heart rate are heritable (h 2 =0.34). However, few genes associated with heart rate training responses have been identified. The purpose of this study was to perform a genome-wide association study (GWAS) to uncover DNA sequence variants associated with submaximal exercise heart rate training responses in the HERITAGE Family Study. Heart rate was measured during steady-state exercise at 50 Watts (HR50) on two separate days both before and after a 20-week endurance training program in 473 white subjects from 99 families. Illumina HumanCNV370-Quad v3.0 BeadChips were genotyped using Illumina BeadStation 500GX platform. After quality control procedures, 320,000 single-nucleotide polymorphisms (SNPs) were available for the GWAS analyses. Associations between HR50 training response (ΔHR50) and the SNPs were tested using the MERLIN software package (single-SNP analyses) and standard regression models (multivariate analyses). Furthermore, conditional heritability analysis (MERLIN) was used to test the contribution of the most significant SNPs to the heritability of ΔHR50. Exercise training induced an average reduction of 11 bpm in HR50 (SD = 9.9 bpm, p<0.0001), while individual training responses ranged from a 12 bpm increase to a 42 bpm decrease. The strongest associations for ΔHR50 (adjusted for age, sex, BMI and baseline HR50) were detected with SNPs at the YWHAQ locus on chromosome 2p25 (p=8.1x10 -7 ), RBPMS locus on 8p12 (p=3.8x10 -6 ) and CREB1 locus on 2q34 (p=1.6x10 -5 ). In addition, 37 other SNPs showed p-values < 9.9x10 -5 . After removing redundant SNPs, the ten most significant SNPs explained 35.9% of the ΔHR50 variance in a multivariate regression model. Conditional heritability test showed that nine of these SNPs (all intragenic) accounted for 100% of the ΔHR50 heritability. Our results indicate that SNPs in nine genes related to cardiomyocyte and neuronal functions as well as cardiac memory formation fully account for the heritability of submaximal exercise heart rate response to regular physical activity in the HERITAGE Family Study.

scholarly journals Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs

2012 ◽  
Vol 112 (5) ◽  
pp. 892-897 ◽  
Author(s):  
Tuomo Rankinen ◽  
Yun Ju Sung ◽  
Mark A. Sarzynski ◽  
Treva K. Rice ◽  
D. C. Rao ◽  
...  
Keyword(s):  
Heart Rate ◽  
Association Study ◽  
Endurance Training ◽  
Genome Wide Association Study ◽  
Submaximal Exercise ◽  
Genome Wide Association ◽  
Exercise Heart Rate ◽  
Genome Wide ◽  
A Genome ◽  
Training Response

Endurance training-induced changes in hemodynamic traits are heritable. However, few genes associated with heart rate training responses have been identified. The purpose of our study was to perform a genome-wide association study to uncover DNA sequence variants associated with submaximal exercise heart rate training responses in the HERITAGE Family Study. Heart rate was measured during steady-state exercise at 50 W (HR50) on 2 separate days before and after a 20-wk endurance training program in 483 white subjects from 99 families. Illumina HumanCNV370-Quad v3.0 BeadChips were genotyped using the Illumina BeadStation 500GX platform. After quality control procedures, 320,000 single-nucleotide polymorphisms (SNPs) were available for the genome-wide association study analyses, which were performed using the MERLIN software package (single-SNP analyses and conditional heritability tests) and standard regression models (multivariate analyses). The strongest associations for HR50 training response adjusted for age, sex, body mass index, and baseline HR50 were detected with SNPs at the YWHAQ locus on chromosome 2p25 ( P = 8.1 × 10−7), the RBPMS locus on chromosome 8p12 ( P = 3.8 × 10−6), and the CREB1 locus on chromosome 2q34 ( P = 1.6 × 10−5). In addition, 37 other SNPs showed P values <9.9 × 10−5. After removal of redundant SNPs, the 10 most significant SNPs explained 35.9% of the ΔHR50 variance in a multivariate regression model. Conditional heritability tests showed that nine of these SNPs (all intragenic) accounted for 100% of the ΔHR50 heritability. Our results indicate that SNPs in nine genes related to cardiomyocyte and neuronal functions, as well as cardiac memory formation, fully account for the heritability of the submaximal heart rate training response.

Heart rate and blood pressure changes with endurance training: The HERITAGE Family Study

2001 ◽  
pp. 107-116 ◽  
Author(s):  
JACK H. WILMORE ◽  
PHILIP R. STANFORTH ◽  
JACQUES GAGNON ◽  
TREVA RICE ◽  
STEPHEN MANDEL ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Endurance Training ◽  
Family Study ◽  
Pressure Changes

Heart Rate Response to Submaximal Exercise: Relation to Age and Sex

1968 ◽  
Vol 23 (2) ◽  
pp. 127-133 ◽  
Author(s):  
H. J. Montoye ◽  
P. W. Willis ◽  
D. A. Cunningham
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Submaximal Exercise ◽  
Age And Sex

Ambulatory Activity and Simple Cardiorespiratory Parameters at Rest and Submaximal Exercise

2003 ◽  
Vol 28 (5) ◽  
pp. 699-709 ◽  
Author(s):  
Catrine Tudor-Locke ◽  
Barbara E. Ainsworth ◽  
Melicia C. Whitt ◽  
Raymond W. Thompson ◽  
Cheryl L. Addy ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Heart Rate ◽  
Inverse Relationship ◽  
Vigorous Physical Activity ◽  
Submaximal Exercise ◽  
Ambulatory Activity ◽  
Graded Exercise Test ◽  
Graded Exercise ◽  
The Relationship

The purpose of this study was to explore the relationship between objectively determined ambulatory activity and simple cardiorespiratory parameters (heart rate and blood pressure at rest and during submaximal exercise) in individuals who were stratified for self-reported participation (yes/any vs. no/none) in vigorous physical activity (PA). Ninety-eight subjects (African Americans: 7 M, 16 F; Caucasians: 33 M, 42 F; mean age 46.4 ± 15.4 yrs; mean BMI 26.7 ± 4.8) wore a pedometer for 21 consecutive days and completed a 10-min submaximal treadmill graded exercise test with HR (beats/min) and BP (mmHg) measured while walking at 4.8 km/hr and a 10% grade. Subjects averaged 7,618 ± 3,045 steps/day. There were no differences in steps/day by self-reported vigorous PA strata. There was an inverse relationship (r = −0.35, p = 0.03) between steps/day and resting HR in subjects who reported no vigorous PA. There was an inverse relationship (r = −0.22, p = 0.04) between steps/day and submaximal HR in all subjects. When stratified for self-reported vigorous PA, the inverse relationship between steps/day and submaximal HR was stronger for those reporting no vigorous PA (r = −0.39, p = 0.01) vs. those reporting any vigorous PA (r = 0.28, p = 0.05). There was no relationship between steps/day and BP at rest or during exercise in this normotensive sample. Key words: walking, blood pressure, heart rate

scholarly journals Efectos fisiológicos agudos de un dispositivo para ejercitarse en casa (Acute physiological response to exercising with a piece of home equipment )

Retos ◽  
2021 ◽  
Vol 43 ◽  
pp. 544-549
Author(s):  
Johnny Alberto Montoya Arroyo ◽  
Jimena Ramírez Cambronero ◽  
Luis Fernando Aragón Vargas 
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Energy Expenditure ◽  
Peripheral Circulation ◽  
Regular Physical Activity ◽  
Home Exercise ◽  
Physiological Effects ◽  
Minute Period ◽  
Important Health ◽  
Exercise Equipment

A la luz de la importancia de la actividad física regular como un elemento clave en la prevención de muchas enfermedades, se reportan a continuación los resultados del estudio realizado con un aparato para ejercitarse en la casa. 22 estudiantes universitarios jóvenes, aparentemente saludables, participaron en el estudio. Se midió el efecto agudo de 10 minutos de ejercicio con el dispositivo sobre la frecuencia cardíaca, el costo energético y la circulación periférica en las piernas. Se contrastan los resultados obtenidos con las afirmaciones que se hacen en distintas versiones de publicidad del aparato en cuestión. No se obtuvieron efectos fisiológicos agudos significativos de la utilización del dispositivo durante 10 minutos continuos: la frecuencia cardíaca aumentó apenas 8 latidos por minuto con respecto al reposo y la temperatura cutánea no varió o más bien disminuyó. El costo energético no fue significativamente mayor mientras se usaba el dispositivo en comparación con la condición de reposo. Estos resultados sugieren que aquellas personas que utilicen este dispositivo en sustitución de la actividad física regular estarán sacrificando beneficios importantes para su salud.  Abstract. The importance of doing regular physical activity (exercise) as a key element in the prevention of several diseases is well known. The following experiment was performed to evaluate the acute physiological effects of a home-exercise machine on 22 young, apparently healthy, university students. While the individuals exercised in the machine for ten (10) minutes, measures of heart rate, energy expenditure and peripheral circulation to the legs were taken and recorded. The results were contrasted against the claims made in different ads promoting the selected apparatus. There were no significant acute physiological effects resulting from the utilization of the machine during a 10-minute period. Heart rate increased only 8 beats per minute (bpm) from baseline and the temperature measured on the legs showed no variation or was even reduced. Energy expenditure was not significantly higher while using the device in comparison with the resting condition. These results suggest that consumers using this home-exercise equipment as a substitute of performing regular physical activity will be sacrificing important health benefits.

NON-INVASIVE ESTIMATION OF THE LACTATE THRESHOLD FROM HEART RATE RESPONSE TO SUBMAXIMAL EXERCISE

1992 ◽  
Vol 24 (Supplement) ◽  
pp. S166
Author(s):  
J. C. Gonzalez ◽  
A. Oliveira ◽  
F. Cheaello ◽  
E. Grassi ◽  
J. P. Hiboiro
Keyword(s):  
Heart Rate ◽  
Lactate Threshold ◽  
Heart Rate Response ◽  
Submaximal Exercise ◽  
Non Invasive
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