Abstract 9610: Aortic Stiffness and Increased Left Ventricular Mass Predict Progress From Prehypertension to Hypertension

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yong H Kim ◽  
Seong-Hwan Kim ◽  
Jin-Seok Kim ◽  
Chol Shin ◽  
Seung-Ku Lee
Keyword(s):  
Left Ventricular Mass ◽  
Aortic Stiffness ◽  
Left Atrial Volume ◽  
Left Ventricular ◽  
Volume Index ◽  
Final Visit ◽  
Ventricular Mass ◽  
Lv Mass ◽  
Fast Increase ◽  
High Range

Introduction: Whether aortic stiffness and increased left ventricular (LV) mass can predict progress from prehypertension to hypertension is not well investigated. Hypothesis: The aim of this study was to find predictors of hypertension and evaluate the clinical implications of aortic stiffness and increased LV mass in disease-free prehypertensive population. Methods: 510 prehypertensive subjects in the Korean Genome Epidemiology Study (KoGES) were observed for four years. In addition to clinical information, left ventricular mass index (LVMI), left atrial volume index (LAVI), aortic pulse wave velocity (PWV), carotid intima-media thickness (cIMT) and other cardiovascular characteristics were obtained at baseline. Baseline clinical and cardiovascular characteristics were compared between subjects that developed hypertension and did not, and independent predictors of hypertension were determined. Results: Out of 510 participants, 237 subjects developed hypertension during four years (46%). After multivariate adjustment, high range prehypertension (OR=4.27 [2.63-9.63], p=0.000), 5th quintile of LAVI (OR=3.38 [1.63-7.04], p=0.001), 5th quintile of LVMI (OR=2.982 [1.399-6.359], p=0.005), 4th (OR=2.881 [1.372-6.049], p=0.005) and 5th quintiles of PWV (OR=2.283 [1.067-4.885], p=0.033) predicted development of hypertension. Subjects in low range prehypertension at baseline and hypertension at the final visit (“fast increase in blood pressure (BP)”) had the highest baseline LVMI, while those with high range prehypertension at baseline and not-hypertension at the final visit ("slow increase in BP") had the lowest baseline LVMI (p=0.005 for fast BP increase vs. slow BP increase). Conclusions: In prehypertensive population, presence of aortic stiffness and increased LV mass independently predicted development of hypertension. Further, increased LVMI at baseline was correlated with fast increase in BP in the future. PWV and echocardiography should be performed to recognize subjects at high risk of hypertension, because they possibly benefit from pre-emptive medical treatment.

Abstract 432: Race Differences in the Relationship between Urinary ET-1 and BP-related Target Organ Damage in Youth

Hypertension ◽  
2012 ◽  
Vol 60 (suppl_1) ◽  
Author(s):  
Gregory A Harshfield ◽  
Gregory A Harshfield ◽  
Jennifer Pollock ◽  
David Pollock
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Mass ◽  
Target Organ Damage ◽  
Albumin Excretion Rate ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
Related Target ◽  
Ventricular Mass ◽  
Lv Mass

The overall goal of this study was to determine race/ethnic differences in the associations between renal ET-1 and indices of blood pressure-related target organ damage in healthy adolescents. The subjects ranged in age between 15-19 years, had no history of any disease, and were not on any prescription medications. The 92 subjects consisted of 48 Caucasians (CA) and 44 African-Americans (AA). The two groups were similar with respect to height, weight, body mass index, blood pressure, ET-1), albumin excretion rate (AER), and left ventricular mass). Results: The CA’s were slightly older 17±1 v 16±1 (p=.02). The protocol was preceded by a 3 day self-selected sodium controlled diet of 250 mEq/day day which the subject picked up each day. The test day began with an echocardiogram for the assessment of left ventricular mass. Next, the subjects were seated for 60 minutes of rest during which the subjects consumed 200 ml of water. This was followed by the collection of a urine sample for the measurement of ET-1 and AER. Overall, ET-1 excretion was correlated with AER (r=.278), LV mass/ht 2.7 (r=.341), and systolic blood pressure (SBP; r=.365; p=.01 for each). The significant overall correlations were the result of significant correlations in AAs for AER (r=.344; p=.05), LV mass/ht 2.7 (r=.520; p=.01), and SBP (r=.645; p=.01) which were not apparent in CA’s. These findings suggest urinary ET-1 contributes to the development of BP-related target organ damage in AA youths prior to the development of increases in blood pressure.

scholarly journals High vitamin K status is prospectively associated with decreased left ventricular mass in women: the Hoorn Study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Joline W. J. Beulens ◽  
Elisa Dal Canto ◽  
Coen D. A. Stehouwer ◽  
Roger J. M. W. Rennenberg ◽  
Petra J. M. Elders ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Ventricular Mass ◽  
Vitamin K ◽  
Left Ventricular ◽  
Volume Index ◽  
Left Ventricular Ejection ◽  
Cardiac Structure ◽  
High Vitamin ◽  
Ventricular Mass

Abstract Background Vitamin K is associated with reduced cardiovascular disease risk such as heart failure, possibly by carboxylation of matrix-gla protein (MGP), a potent inhibitor of vascular calcification. The relationship of vitamin K intake or status with cardiac structure and function is largely unknown. Therefore this study aims to investigate the prospective association of vitamin K status and intake with echocardiographic measures. Methods This study included 427 participants from the Hoorn Study, a population-based cohort. Vitamin K status was assessed at baseline by plasma desphospho-uncarboxylated MGP (dp-ucMGP) with higher concentrations reflecting lower vitamin K status. Vitamin K intake was assessed at baseline with a validated food-frequency questionnaire. Echocardiography was performed at baseline and after a mean follow-up time of 7.6, SD=±0.7 years. We used linear regression for the association of vitamin K status and intake with left ventricular ejection fraction (LVEF), left atrial volume index (LAVI) and left ventricular mass index (LVMI), adjusted for potential confounders. Results The mean age was 66.8, SD=±6.1 years (51% were male). A high vitamin K status was prospectively associated with decreased LVMI (change from baseline to follow-up: -5.0, 95% CI: -10.5;0.4 g/m2.7) for the highest quartile compared to the lowest in women (P-interaction sex=0.07). No association was found in men. Vitamin K status was not associated with LVEF or LAVI. Vitamin K intake was not associated with any of the echocardiographic measures. Conclusions This study showed a high vitamin K status being associated with decreased LVMI only in women, while intakes of vitamin K were not associated with any cardiac structure or function measures. These results extend previous findings for a role of vitamin K status to decrease heart failure risk.

Increased central aortic stiffness and left ventricular mass in normotensive young subjects after successful coarctation repair

2008 ◽  
Vol 155 (1) ◽  
pp. 187-193 ◽  
Author(s):  
Phalla Ou ◽  
David S. Celermajer ◽  
Odile Jolivet ◽  
Fanny Buyens ◽  
Alain Herment ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Aortic Stiffness ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Coarctation Repair ◽  
Young Subjects

scholarly journals Effect of Spironolactone on Left Ventricular Mass and Aortic Stiffness in Early-Stage Chronic Kidney Disease

2009 ◽  
Vol 54 (6) ◽  
pp. 505-512 ◽  
Author(s):  
Nicola C. Edwards ◽  
Richard P. Steeds ◽  
Paul M. Stewart ◽  
Charles J. Ferro ◽  
Jonathan N. Townend
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Left Ventricular Mass ◽  
Aortic Stiffness ◽  
Early Stage ◽  
Left Ventricular ◽  
Ventricular Mass
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