Abstract P167: High vs. Standard Protein Diets in Obese Patients with Heart Failure: Effects on Chronic Disease Risks

Circulation ◽  
2017 ◽  
Vol 135 (suppl_1) ◽  
Author(s):  
Lorraine S Evangelista ◽  
Dawn Lombardo ◽  
Tamara Horwich ◽  
Michele Hamilton ◽  
Gregg C Fonarow
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Chronic Disease ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Obese Patients ◽  
Patients With Heart Failure ◽  
Disease Risks ◽  
Standard Protein

Background: There is controversy over dietary protein’s effect on long-term chronic disease risks in overweight and obese patients with heart failure. The aim of this study was to compare the effects of two calorie-restricted diets differing in protein content on chronic disease risks (e.g., weight, adiposity, glycemic control, lipid profiles, and blood pressure). Methods: A total of 97 overweight and obese (mean body mass index [BMI], 37.0 ± 6.2 kg/m 2 ) patients with heart failure, aged 58.8 ± 9.7 years, 70% males, consumed two diets, each for 12 weeks, in a randomized controlled design. The diets were: (1) a high protein diet (30% protein, 40% carbohydrates, and 30% fat) and (2) a standard protein diet (15% protein, 55% carbohydrates, and 30% fat). Their effects on weight (BMI) visceral fat (i.e. waist circumference), glycemic control (i.e. glycosylated hemoglobin [HgbA1C]), lipid profiles (total cholesterol [TC], low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglycerides [TG]), and blood pressure at the beginning and end of each dietary intervention were analyzed. Results: Both diets were equally effective in promoting weight loss and visceral fat loss and in improving TC, but the high protein diet decreased to a greater extent HgbA1C levels ( P < 0.001) when compared with the standard protein diet. The high protein diet improved significantly TG levels ( P < 0.001) and both systolic and diastolic blood pressures when compared with the standard protein diet ( P < 0.001 and P < 0.001, respectively, see figure). No differences were noted in LDL and HDL levels. Conclusion: Energy restricted diets facilitate weight loss and visceral fat loss and lower TC in overweight and obese patients with heart failure. However, the high protein diet promoted better improvements in TG levels, glycemic control, and blood pressure than the standard protein diet, and may be superior in reducing chronic disease risks and potentially slowing the progression of disease in this population.

scholarly journals HIGH VERSUS STANDARD PROTEIN DIETS IN OBESE PATIENTS WITH HEART FAILURE: EFFECTS ON CHRONIC DISEASE RISKS

2017 ◽  
Vol 69 (11) ◽  
pp. 850
Author(s):  
Lorraine S. Evangelista ◽  
Dawn Lombardo ◽  
Tamara Horwich ◽  
Michele Hamilton ◽  
Gregg Fonarow
Keyword(s):  
Heart Failure ◽  
Chronic Disease ◽  
Obese Patients ◽  
Patients With Heart Failure ◽  
Disease Risks ◽  
Protein Diets ◽  
Standard Protein

Nephron number and blood pressure in rat offspring with maternal high-protein diet

2002 ◽  
Vol 17 (12) ◽  
pp. 1000-1004 ◽  
Author(s):  
Monika Zimanyi ◽  
John Bertram ◽  
Jane Black
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Nephron Number ◽  
Rat Offspring

Dietetic Treatment of Diabetes Mellitus with Special Reference to High Blood-Pressure

1938 ◽  
Vol 31 (10) ◽  
pp. 1183-1204
Author(s):  
Dennis Embleton
Keyword(s):  
Blood Pressure ◽  
High Protein Diet ◽  
Normal Glucose Tolerance ◽  
High Protein ◽  
Protein Diet ◽  
Normal Glucose ◽  
Glucose Tolerance Curve ◽  
Treatment Of Diabetes ◽  
Tolerance Curve ◽  
Carbohydrate Intolerance

The error in a diabetic is essentially a carbohydrate intolerance, and correction of this defect should be aimed at in treatment. Dietetic treatment of diabetes is more readily studied in early cases or cases in the pre-diabetic state, before arterial degeneration and other catastrophes have become manifest. It is suggested that such a condition exists in obese subjects with a carbohydrate intolerance. A high protein diet based on a study of these cases is brought forward. This diet has been shown to operate favourably in diabetic states. Many cases of reasonable severity can be brought to develop a normal or nearly normal glucose tolerance curve and retain this state over a period of years. Cases in this state are better able to resist concomitant infections without deterioration of their tolerance than cases imperfectly balanced with insulin. The high protein diet can be used in cases of hyperpiesia in the absence of gross kidney damage. These cases show a steady and lasting drop in blood-pressure without the necessity of employing rest. The value of the pure fruit diet in increasing tolerance of certain diabetics to carbohydrate is demonstrated. The indiscriminate use of insulin in hyperglycæmic states is deprecated on the grounds that it is frequently unnecessary, and though it may balance it does not necessarily rectify the main deficiency of carbohydrate intolerance. By the use of this simple high protein diet, where no weighing, &c., is required, a large number of diabetics at present on insulin could be readily dealt with, a return to a normal or nearly normal glucose tolerance curve being obtained and maintained.

scholarly journals THE EFFECT OF HIGH PROTEIN DIETS ON EXPERIMENTAL RENAL HYPERTENSION

1941 ◽  
Vol 74 (6) ◽  
pp. 591-600 ◽  
Author(s):  
H. Philipsborn ◽  
L. N. Katz ◽  
S. Rodbard
Keyword(s):  
Blood Pressure ◽  
Renal Hypertension ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Low Protein ◽  
Experimental Renal Hypertension ◽  
High Protein Diets ◽  
Protein Diets

The effect of high and low protein diets were studied on fourteen dogs in twenty-four different experiments. In only two of these animals, both with moderate renal excretory failure, was a reversible rise in blood pressure elicited by a high protein diet. The possible mechanisms involved in meeting an increased excretory load are discussed.

scholarly journals Comparison of body composition changes between low calorie high protein diet to standard protein in obese individuals with weight cycling – a randomised trial

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 445 ◽  
Author(s):  
Joan Jutamulia ◽  
Adventia Natali Paranoan ◽  
Septian Ika Prasetya ◽  
Ninik Mudjihartini ◽  
Fiastuti Witjaksono
Keyword(s):  
Body Composition ◽  
Fat Mass ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Weight Cycling ◽  
Low Calorie ◽  
Protein Group ◽  
History Of ◽  
Standard Protein

Background: The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases. A large proportion of people who had succeeded to reduce body weight failed to maintain it (weight cycling). Studies were inconclusive about the best composition in the diet for such people. The purpose of this research was to evaluate the body composition changes resulted from low calorie high protein and standard protein diet programme in obese people with history of weight cycling. Methods: This is an open-randomized clinical trial of weight loss program as a part of a larger study researching the effect of low calorie high protein diet to body composition, oxidative stress, inflammation marker and metabolic syndrome in obese with weight cycling. A total of 61 adult obese men and women with history of weight cycling were recruited. Subjects were assigned to low calorie diet and were randomly distributed into two intervention groups, namely high protein group (22-30 % of total calories intake) and standard protein group (12-20%). Anthropometry and body composition data were taken at baseline and at the end of the study. Subjects were followed up to 8 weeks with daily reminder and weekly counselling. Results: Fourty five participants completed the study. There were significant reductions in in body weight and body mass index (BMI), fat mass, fat mass percentage, muscle mass, and gain in muscle mass percentage occurred in both groups (Standard protein: P<0.001; High protein: P<0.001 for all variables except for fat mass P= 0,001) with no difference between group (P>0.05). Conclusion: Calories deficit with either high protein or standard protein for 8 weeks brought about significant reduction in body composition

Abstract P105: Dietary Acid Load of a Low Versus a High Protein Diet and Its Effect on Blood Pressure: A Fully Controlled Dietary Intervention Trial

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Marielle F Engberink ◽  
Wieke Altorf-van der Kuil ◽  
Elizabeth J Brink ◽  
Stephan J Bakker ◽  
Marleen A van Baak ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Protein Intake ◽  
Dietary Intervention ◽  
High Protein Diet ◽  
Healthy Adults ◽  
High Protein ◽  
Protein Diet ◽  
Dietary Acid Load ◽  
Dietary Acid ◽  
Acid Load

Background: Mild metabolic acidosis may result in elevated blood pressure (BP). Several formulas to estimate dietary acid load have been developed. However, studies in which these formulas have been validated are limited. Objectives: To validate and/or improve existing formulas for dietary acid load and to examine the association between dietary protein, acid load and BP. Methods: We performed a randomized 14d crossover dietary intervention involving 37 healthy subjects (age: 21±2 y) who consumed individualized, isocaloric diets that were either low or high in protein (0.5 versus 2.0 g protein/kg BW/d). Duplicate portions of the provided diets were collected and analysed for energy and nutrients. We used two measures to characterize dietary acid load (i.e. PRAL and NEAP). Urinary Net Acid Excretion (NAE; i.e. titratable acid + ammonium - bicarbonate) was analysed. BP was measured according to standardized procedures. Results: Mean dietary intakes significantly differed between the low and high protein diet, resulting in significantly different acid load values (Table 1, all p<0.001). The correlation between PRAL and NAE was 0.08 in the low protein diet and 0.62 in the high protein diet. For NEAP the correlations were 0.27 and 0.32. PRAL explained 69% of the variance of NAE, which could not be improved by adding other variables to the formula. Systolic BP was 108.4±7.5 and 109.5±8.0 mmHg on the low and high protein diet respectively (p=0.25). Conclusion: PRAL predicts NAE reasonably well in healthy adults for normal to high protein intake. PRAL can be influenced by diet, but this cannot be clearly attributed to protein intake alone. PRAL does not seem to influence short-term BP in healthy adults with normal BP.

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