Abstract P162: Comorbid Asthma And Allergies Are Common In Children With Congenital Heart Disease And Related To Decreased Physical Functioning

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Rochelle Medford ◽  
Carolyn Drews-Botsch ◽  
Michael Kramer ◽  
Matthew Oster ◽  
Bryan Williams ◽  
...  
Keyword(s):  
Physical Health ◽  
Physical Functioning ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects ◽  
Asthma Diagnosis ◽  
Sibling Pairs ◽  
Reported Data ◽  
Allergies And Asthma ◽  
Similar Risk

Background: Congenital heart defects (CHD) are the most common birth defect and asthma and allergies are common conditions in childhood. The co-occurrence of these is not well understood but may be increased due to similar risk factors or immune dysregulation related to early life inflammation. This study aimed to compare the prevalence of asthma and allergies between children with CHD and their unaffected siblings and assess their impact on physical functioning in children with CHD. Methods: Parent-reported data was collected on allergy medications and asthma diagnosis, physical functioning (PedsQL physical health), and characteristics in children (age 12-17) with surgically treated CHD and an unaffected sibling (age 11-18). The McNemar test compared the comorbidities between siblings. Among children with CHD, logistic and linear regression were used to estimate the association of each comorbidity with child characteristics and physical functioning respectively. Models included CHD severity, SES, age, BMI, and sex. Results: Among 218 sibling pairs, the children with CHD had a higher, but not statistically significant, prevalence of asthma and allergies (Figure 1). In all 497 children with CHD, single ventricle CHD had a 2.5 times greater odds of allergies compared with non-critical (95%CI=1.0,6.0) with no difference in asthma. Asthma was associated with decreased physical functioning (8.7 point decrease vs no asthma, 95%CI=-14.5,-2.9). Conclusions: Children with CHD and their siblings had similar levels of allergies and asthma. However, as symptoms of these conditions may overlap, studies should further investigate a possible link with CHD, especially given the lower physical health in patients with CHD and asthma.

scholarly journals Down syndrome and congenital heart disease: perioperative planning and management

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Dennis R. Delany ◽  
Stephanie S. Gaydos ◽  
Deborah A. Romeo ◽  
Heather T. Henderson ◽  
Kristi L. Fogg ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Down Syndrome ◽  
Cardiac Surgery ◽  
Heart Disease ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects ◽  
Careful Consideration ◽  
Children With Down Syndrome ◽  
Perioperative Planning

AbstractApproximately 50% of newborns with Down syndrome have congenital heart disease. Non-cardiac comorbidities may also be present. Many of the principles and strategies of perioperative evaluation and management for patients with congenital heart disease apply to those with Down syndrome. Nevertheless, careful planning for cardiac surgery is required, evaluating for both cardiac and noncardiac disease, with careful consideration of the risk for pulmonary hypertension. In this manuscript, for children with Down syndrome and hemodynamically significant congenital heart disease, we will summarize the epidemiology of heart defects that warrant intervention. We will review perioperative planning for this unique population, including anesthetic considerations, common postoperative issues, nutritional strategies, and discharge planning. Special considerations for single ventricle palliation and heart transplantation evaluation will also be discussed. Overall, the risk of mortality with cardiac surgery in pediatric patients with Down syndrome is no more than the general population, except for those with functional single ventricle heart defects. Underlying comorbidities may contribute to postoperative complications and increased length of stay. A strong understanding of cardiac and non-cardiac considerations in children with Down syndrome will help clinicians optimize perioperative care and long-term outcomes.

Challenges of Caring for Functionally Single Ventricle Patients in Africa

2019 ◽  
Vol 10 (3) ◽  
pp. 338-342 ◽  
Author(s):  
Frank Edwin ◽  
Mohamed-Adel Elgamal ◽  
Abid Dorra ◽  
Darshan Reddy ◽  
Kow Entsua-Mensah ◽  
...  
Keyword(s):  
Health Care ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects ◽  
Health Care Coverage ◽  
The Poor ◽  
Developed Nations ◽  
Political Priority ◽  
Poor Care ◽  
Improve Health

Surgical palliation has remarkably improved survival of functionally single ventricle (FSV) patients born in developed nations but such outcomes have not occurred in Africa. The poor care coverage for FSV patients in Africa exists within the larger sphere of deficient health care for children born with congenital heart defects (CHDs) in Africa generally. This review takes the position that to improve health-care coverage for CHD patients on the continent, political priority is paramount. This can be attained with cohesive leadership for the CHD agenda, a guiding institution, and the mobilization of civil society to drive advocacy at national and international levels.

Effect of Flow Pulsatility on 2nd Stage Fontan Hemodynamics: An In Vitro Investigation

2009 ◽  
Author(s):  
Christopher M. Haggerty ◽  
Lakshmi P. Dasi ◽  
Jessica Kanter ◽  
Ajit P. Yoganathan
Keyword(s):  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects ◽  
Superior Vena ◽  
Fontan Procedure ◽  
Pulmonary Arteries ◽  
Vena Cava ◽  
Second Stage ◽  
In Vitro Investigation

The Fontan procedure [1] is the staged, palliative surgical approach used to treat patients suffering from single ventricle congenital heart defects. The second stage of this procedure involves the connection of the superior vena cava (SVC) to the pulmonary arteries (PAs) in either an end-to-side (known as the Bi-Directional Glenn (BDG)) or side-to-side (or Hemi-Fontan (HF)) fashion. Because of obvious disparities at the connection site, there are understandable differences in the fluid dynamics between the two geometries.

scholarly journals Two-ventricle repair for complex congenital heart defects palliated towards single-ventricle repair

2013 ◽  
Vol 18 (3) ◽  
pp. 266-271 ◽  
Author(s):  
B. P. Kottayil ◽  
G. S. Sunil ◽  
M. Kappanayil ◽  
S. H. Mohanty ◽  
E. Francis ◽  
...  
Keyword(s):  
Congenital Heart Defects ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects

scholarly journals Congenital heart anomaly «single ventricle»: structural and functional diagnosis in everyday practice

2016 ◽  
Vol 97 (2) ◽  
pp. 295-299
Author(s):  
D N Samigullina ◽  
N A Tsibulkin
Keyword(s):  
Left Ventricle ◽  
Congenital Heart ◽  
Single Ventricle ◽  
Heart Defects ◽  
Data Interpretation ◽  
Systemic Circulation ◽  
Diagnostic Features ◽  
Atrioventricular Valves ◽  
Functional Diagnosis ◽  
Number Of Factors

Diagnosis and description of rare congenital heart anomalies are great challenges for the ultrasonographer. The biggest difficulties arise in hospitals, which do not have specialization in pediatrics or cardiac surgery. A rare form of congenital heart defects is a group of anomalies, unitedly defined as «single ventricle». Severe hemodynamic disturbances and unfavorable course of the disease reduce the possibility to detect this defect in adolescence or adulthood. Single ventricle, as the anomaly main feature, can occur in different forms of pathology. The most commonly single ventricle syndrome includes left heart hypoplasia, tricuspid atresia, and double inlet single ventricle syndromes. The most favorable course have cases when a single ventricle anatomically is left ventricle along with separate and properly formed atrioventricular valves, in the absence of main arteries significant stenosis and their normal location. This variant of a double inlet single ventricle is known as the «Holmes heart». Echocardiographic diagnosis allows to detail the anatomical and functional defects that are present in each case. Detailed identification of diagnostic features allows to specify the diagnosis and avoid inconsistencies in the obtained data interpretation. We present a clinical case of one of the most rare forms of these disease. The described case feature, in addition to its rarity, is long compensated course of defect. The lack of obvious signs of heart failure in this case may be due to a number of factors, such as a balance between the pulmonary and systemic circulation, absence of progressive changes in the pulmonary circulation blood vessels, atrioventricular valves functional adequacy, the absence of stenosis and valves changes of the main arteries, anatomically left ventricle with sufficient contractility.

Sign in / Sign up

Export Citation Format

Share Document