Abstract 392: Chronic Dantrolene Treatment Attenuates Cardiac Dysfunction and Reduces Atrial Fibrillation Inducibility in a Rat Myocardial Infarction Heart Failure Model

2018 ◽  
Vol 123 (Suppl_1) ◽  
Author(s):  
Colleen Nofi ◽  
Kuo Zhang ◽  
Ying Li ◽  
Allan Migirov ◽  
Kaie Ojamaa ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiac Dysfunction ◽  
Failure Model ◽  
Heart Failure Model ◽  
Infarction Heart

Reduced epicardial vagal nerve density and impaired vagal control in a rat myocardial infarction–heart failure model

2017 ◽  
Vol 26 ◽  
pp. 21-29 ◽  
Author(s):  
Matthew S. Delfiner ◽  
John Siano ◽  
Ying Li ◽  
Eduard I. Dedkov ◽  
Youhua Zhang
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Vagal Nerve ◽  
Failure Model ◽  
Vagal Control ◽  
Heart Failure Model ◽  
Infarction Heart

scholarly journals JDP2, a Novel Molecular Key in Heart Failure and Atrial Fibrillation?

2021 ◽  
Vol 22 (8) ◽  
pp. 4110
Author(s):  
Gerhild Euler ◽  
Jens Kockskämper ◽  
Rainer Schulz ◽  
Mariana S. Parahuleva
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Cardiac Dysfunction ◽  
Therapeutic Target ◽  
Close Correlation ◽  
Disease Development ◽  
Major Life ◽  
Life Threatening ◽  
Current Therapies

Heart failure (HF) and atrial fibrillation (AF) are two major life-threatening diseases worldwide. Causes and mechanisms are incompletely understood, yet current therapies are unable to stop disease progression. In this review, we focus on the contribution of the transcriptional modulator, Jun dimerization protein 2 (JDP2), and on HF and AF development. In recent years, JDP2 has been identified as a potential prognostic marker for HF development after myocardial infarction. This close correlation to the disease development suggests that JDP2 may be involved in initiation and progression of HF as well as in cardiac dysfunction. Although no studies have been done in humans yet, studies on genetically modified mice impressively show involvement of JDP2 in HF and AF, making it an interesting therapeutic target.

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