scholarly journals Early Magnetic Resonance Imaging in Transient Ischemic Attack and Minor Stroke

Stroke ◽  
2013 ◽  
Vol 44 (3) ◽  
pp. 671-674 ◽  
Author(s):  
François Moreau ◽  
Jayesh Modi ◽  
Mohammed Almekhlafi ◽  
Simer Bal ◽  
Mayank Goyal ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
Minor Stroke ◽  
Resonance Imaging ◽  
Ischemic Attack

scholarly journals Dabigatran following acute transient ischemic attack and minor stroke II (DATAS II)

2017 ◽  
Vol 12 (8) ◽  
pp. 910-914 ◽  
Author(s):  
Kuan H Ng ◽  
Mukul Sharma ◽  
Oscar Benavente ◽  
Laura Gioia ◽  
Thalia S Field ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Ischemic Stroke ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
Hemorrhagic Transformation ◽  
Phase Iii ◽  
Minor Stroke ◽  
Resonance Imaging ◽  
Repeat Magnetic Resonance Imaging ◽  
Ischemic Attack

Rationale Patients with transient ischemic attack or minor stroke are at high risk of early recurrent cerebrovascular events. Anticoagulation with heparin or warfarin acutely after ischemic stroke is at least as efficacious as aspirin for preventing recurrent events but is associated with an increased risk of clinical worsening due to hemorrhagic transformation. Aim and hypothesis We aim to demonstrate the safety of early anticoagulation with dabigatran, an oral direct thrombin inhibitor, in acute cerebrovascular syndrome patients. The primary hypothesis is that symptomatic hemorrhagic transformation rates in dabigatran and aspirin-treated patients will be similar. Sample size estimates At least 136 participants in two groups required to demonstrate an absolute between-group difference in the rate of hemorrhagic transformation of 5.6% with 80% power, assuming alpha = 5%. Methods and design A randomized, multicenter open-label clinical trial (NCT02295826). Three-hundred participants with a transient ischemic attack/ischemic stroke (National Institutes of Health Stroke Scale ≤ 9) will undergo magnetic resonance imaging within 72 h of symptom onset and will be randomized to aspirin 81 mg daily or dabigatran 150 mg twice daily for 30 days. Participants undergo repeat magnetic resonance imaging at 30 days and clinical assessment to 90 days. Study outcomes The primary outcome is the symptomatic hemorrhagic transformation rate. Secondary outcomes include recurrent stroke and new ischemic lesions on repeat magnetic resonance imaging. Discussion This study will determine the safety of early anticoagulation with dabigatran in patients with acute transient ischemic attack/ischemic stroke and will inform the design of a phase III randomized trial aimed at demonstrating reduced recurrent early ischemic events after acute transient ischemic attack/stroke.

Triaging transient ischemic attack and minor stroke patients using acute magnetic resonance imaging

2005 ◽  
Vol 57 (6) ◽  
pp. 848-854 ◽  
Author(s):  
Shelagh B. Coutts ◽  
Jessica E. Simon ◽  
Michael Eliasziw ◽  
Chul-Ho Sohn ◽  
Michael D. Hill ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
Minor Stroke ◽  
Resonance Imaging ◽  
Stroke Patients ◽  
Ischemic Attack

scholarly journals High Rate of Magnetic Resonance Imaging Stroke Recurrence in Cryptogenic Transient Ischemic Attack and Minor Stroke Patients

Stroke ◽  
2012 ◽  
Vol 43 (12) ◽  
pp. 3387-3388 ◽  
Author(s):  
Simerpreet Bal ◽  
Shiel K. Patel ◽  
Mohammed Almekhlafi ◽  
Jayesh Modi ◽  
Andrew M. Demchuk ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
High Rate ◽  
Minor Stroke ◽  
Stroke Recurrence ◽  
Resonance Imaging ◽  
Stroke Patients ◽  
Ischemic Attack

Altered Functional Connectivity within Default Mode Network in Patients with Transient Ischemic Attack: A Resting-State Functional Magnetic Resonance Imaging Study

2019 ◽  
Vol 48 (1-2) ◽  
pp. 61-69 ◽  
Author(s):  
Tingting Zhu ◽  
Lingyu Li ◽  
Yulin Song ◽  
Yu Han ◽  
Chengshu Zhou ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Connectivity ◽  
Functional Magnetic Resonance Imaging ◽  
Transient Ischemic Attack ◽  
Default Mode Network ◽  
Resting State ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Ischemic Attack

Default mode network (DMN) is an important functional brain network that supports aspects of cognition. Stroke has been reported to be associated with functional connectivity (FC) impairments within DMN. However, whether FC within DMN changes in transient ischemic attack (TIA), an important risk factor for stroke, remains unclear. Forty-eight TIA patients and 41 age- and sex-matched healthy controls (HCs) were recruited in this study. Using resting-state functional magnetic resonance imaging seed-based FC methods, we examined FC alterations within DMN in TIA patients, tested its associations with clinical information, and further explored the ability of FC abnormalities to predict follow-up ischemic attacks. We found significantly decreased FC of left middle temporal gyrus/angular gyrus both with medial prefrontal cortex (mPFC) and posterior cingulate cortex/precuneus (PCC/Pcu) and significantly decreased FC among each pair of mPFC, left PCC, and right Pcu in patients with TIA as compared with HCs. Moreover, the connectivity between mPFC and left PCC could predict future ischemic attacks of the patients. Collectively, these findings may provide insights into further understanding of the underlying pathological mechanism in TIA, and aberrant FC between the hubs within DMN may provide a reference for the imaging diagnosis and early intervention of TIA.

Transient Ischemic Attack Patients Do Have Magnetic Resonance Imaging Proven Infarcts (P04.051)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P04.051-P04.051
Author(s):  
H. Zacharatos ◽  
A. Hassan ◽  
S. Chaudhry ◽  
A. Qureshi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Transient Ischemic Attack ◽  
Resonance Imaging ◽  
Ischemic Attack
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