scholarly journals Predictors of Poststroke Aphasia Recovery

Stroke ◽  
2021 ◽  
Author(s):  
◽  
Myzoon Ali ◽  
Kathryn VandenBerg ◽  
Linda J. Williams ◽  
Louise R. Williams ◽  
...  

Background and Purpose: The factors associated with recovery of language domains after stroke remain uncertain. We described recovery of overall-language-ability, auditory comprehension, naming, and functional-communication across participants’ age, sex, and aphasia chronicity in a large, multilingual, international aphasia dataset. Methods: Individual participant data meta-analysis of systematically sourced aphasia datasets described overall-language ability using the Western Aphasia Battery Aphasia-Quotient; auditory comprehension by Aachen Aphasia Test (AAT) Token Test; naming by Boston Naming Test and functional-communication by AAT Spontaneous-Speech Communication subscale. Multivariable analyses regressed absolute score-changes from baseline across language domains onto covariates identified a priori in randomized controlled trials and all study types. Change-from-baseline scores were presented as estimates of means and 95% CIs. Heterogeneity was described using relative variance. Risk of bias was considered at dataset and meta-analysis level. Results: Assessments at baseline (median=43.6 weeks poststroke; interquartile range [4–165.1]) and first-follow-up (median=10 weeks from baseline; interquartile range [3–26]) were available for n=943 on overall-language ability, n=1056 on auditory comprehension, n=791 on naming and n=974 on functional-communication. Younger age (<55 years, +15.4 Western Aphasia Battery Aphasia-Quotient points [CI, 10.0–20.9], +6.1 correct on AAT Token Test [CI, 3.2–8.9]; +9.3 Boston Naming Test points [CI, 4.7–13.9]; +0.8 AAT Spontaneous-Speech Communication subscale points [CI, 0.5–1.0]) and enrollment <1 month post-onset (+19.1 Western Aphasia Battery Aphasia-Quotient points [CI, 13.9–24.4]; +5.3 correct on AAT Token Test [CI, 1.7–8.8]; +11.1 Boston Naming Test points [CI, 5.7–16.5]; and +1.1 AAT Spontaneous-Speech Communication subscale point [CI, 0.7–1.4]) conferred the greatest absolute change-from-baseline across each language domain. Improvements in language scores from baseline diminished with increasing age and aphasia chronicity. Data exhibited no significant statistical heterogeneity. Risk-of-bias was low to moderate-low. Conclusions: Earlier intervention for poststroke aphasia as crucial to maximize language recovery across a range of language domains, although recovery continued to be observed to a lesser extent beyond 6 months poststroke.

2009 ◽  
Vol 24 (4) ◽  
pp. 343-354 ◽  
Author(s):  
J. Pena-Casanova ◽  
S. Quinones-Ubeda ◽  
N. Gramunt-Fombuena ◽  
M. Aguilar ◽  
L. Casas ◽  
...  

2005 ◽  
Vol 19 (3-4) ◽  
pp. 280-328 ◽  
Author(s):  
Brett A. Steinberg ◽  
Linas A. Bieliauskas ◽  
Glenn E. Smith ◽  
Christopher Langellotti ◽  
Robert J. Ivnik

2020 ◽  
Vol 63 (11) ◽  
pp. 3801-3815
Author(s):  
Liqun Yao ◽  
Hongjia Zhao ◽  
Cuiling Shen ◽  
Fang Liu ◽  
Li Qiu ◽  
...  

Objective The aim of the study was to investigate the effectiveness and safety of low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) in patients with poststroke aphasia. Method We comprehensively searched for eligible studies from 11 electronic medical databases from their inception to February 20, 2019. Randomized controlled trials reporting the effectiveness of LF-rTMS for patients with poststroke aphasia were included. The primary outcome was language ability. The secondary outcomes were functional communication and adverse events. The methodological quality of the randomized controlled trials was evaluated by the Cochrane Back Review Group Risk of Bias Assessment Criteria. Results Of the 567 records retrieved, 18 studies with a total of 536 participants were included. All the included studies were of relatively acceptable methodological quality. All studies but one used LF-rTMS + speech and language therapy (SLT), not LF-rTMS alone. The meta-analysis showed that LF-rTMS had beneficial effects for patients with aphasia after a stroke in terms of naming, repetition, comprehension, written language, and functional communication. The subgroup analyses of language performance showed positive effects of LF-rTMS among stroke patients with chronic aphasia and acute aphasia. LF-rTMS + SLT had effects on language performance that were superior to the sham rTMS + SLT and SLT alone. A shorter LF-rTMS duration benefited language performance more than a longer duration. Additionally, 20 min of LF-rTMS per session produced a positive effect on language ability for patients with aphasia after a stroke. No adverse events were reported. Conclusions LF-rTMS + SLT is an effective and safe method for patients with poststroke aphasia to improve their language performance. Additionally, the most commonly used LF-rTMS protocol for patients with aphasia after a stroke was 90% of the resting motor threshold 20 min per day, 5 days per week, for 2 weeks.


Neurología ◽  
2012 ◽  
Vol 27 (7) ◽  
pp. 394-399 ◽  
Author(s):  
F. Aranciva ◽  
M. Casals-Coll ◽  
G. Sánchez-Benavides ◽  
M. Quintana ◽  
R.M. Manero ◽  
...  

1972 ◽  
Vol 37 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Leslie Smith Needham ◽  
Linda Peck Swisher

Three tests of auditory comprehension for aphasic adults were administered: (1) a category of the Functional Communication Profile (FCP), (2) a section of an Aphasia Test, and (3) the Token Test. The results are presented in terms of the relative degree of difficulty of the tests and the relationship between the scores of nontask-oriented and the task-oriented tests. Of the three, the Token Test was found to be the most difficult and the Aphasia Test the easiest. The FCP Understanding category had the widest range of difficulty. For the patients diagnosed as aphasic without additional, nonsymbolic expressive problems, there was a significant relationship between task-oriented and nontask-oriented test scores. An unexpected finding was that Understanding ratings on the FCP were affected by verbal apraxia or dysarthria.


2012 ◽  
Vol 70 (6) ◽  
pp. 410-415 ◽  
Author(s):  
Mariana Jardim Azambuja ◽  
Marcia Radanovic ◽  
Mônica Santoro Haddad ◽  
Carla Cristina Adda ◽  
Egberto Reis Barbosa ◽  
...  

Language alterations in Huntington's disease (HD) are reported, but their nature and correlation with other cognitive impairments are still under investigation. This study aimed to characterize the language disturbances in HD and to correlate them to motor and cognitive aspects of the disease. We studied 23 HD patients and 23 controls, matched for age and schooling, using the Boston Diagnostic Aphasia Examination, Boston Naming Test, the Token Test, Animal fluency, Action fluency, FAS-COWA, the Symbol Digit Modalities Test, the Stroop Test and the Hooper Visual Organization Test (HVOT). HD patients performed poorer in verbal fluency (p<0.0001), oral comprehension (p<0.0001), repetition (p<0.0001), oral agility (p<0.0001), reading comprehension (p=0.034) and narrative writing (p<0.0001). There was a moderate correlation between the Expressive Component and Language Competency Indexes and the HVOT (r=0.519, p=0.011 and r=0.450, p=0.031, respectively). Language alterations in HD seem to reflect a derangement in both frontostriatal and frontotemporal regions.


2012 ◽  
Vol 27 (7) ◽  
pp. 394-399 ◽  
Author(s):  
F. Aranciva ◽  
M. Casals-Coll ◽  
G. Sánchez-Benavides ◽  
M. Quintana ◽  
R.M. Manero ◽  
...  

2001 ◽  
Vol 13 (3) ◽  
pp. 289-298 ◽  
Author(s):  
Tom Bschor ◽  
Klaus-Peter Kühl ◽  
Friedel M. Reischies

This article discusses the potential of three assessments of language function in the diagnosis of Alzheimer-type dementia (DAT). A total of 115 patients (mean age 65.9 years) attending a memory clinic were assessed using three language tests: a picture description task (Boston Cookie-Theft picture), the Boston Naming Test, and a semantic and phonemic word fluency measure. Results of these assessments were compared with those of clinical diagnosis including the Global Deterioration Scale (GDS). The patients were classified by ICD-10 diagnosis and GDS stage as without cognitive impairment (n = 40), mild cognitive impairment (n = 34), mild DAT (n = 21), and moderate to severe DAT (n = 20). Hypotheses were (a) that the complex task of a picture description could more readily identify language disturbances than specific language tests and that (b) examination of spontaneous speech could help to identify patients with even mild forms of DAT. In the picture description task, all diagnostic groups produced an equal number of words. However, patients with mild or moderate to severe DAT described significantly fewer objects and persons, actions, features, and localizations than patients without or with mild cognitive impairment. Persons with mild cognitive impairment had results similar to those without cognitive impairment. The Boston Naming Test and both fluency measures were superior to the picture description task in differentiating the diagnostic groups. In sum, both hypotheses had to be rejected. Our results confirm that DAT patients have distinct semantic speech disturbances whereas they are not impaired in the amount of produced speech.


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