My Life Journey into the Empire of Nobodies, Rogues, “Peoples without History” and Associated History Wars: Origins of the Fatal Attraction of an Historian to ‘Non-history’

The volume reflects L.M. Singhvi’s prodigious scholarship. His signature writing style is brilliant, articulate, fluent, and honest. He believed in maintaining clarity in his writings to make it simple and intelligible to readers, despite the complexity of the issues that he addressed in his works. Dr L.M. Singhvi had a multifaceted personality—author, jurist, statesman, philosopher, and a social reformer. A product of many reputed universities like the University of Allahabad, University of Rajasthan, Harvard University, and Cornell University, he was most celebrated Indian public figure of the contemporary times. A disciple of eminent jurist Dr K.M. Munshi, he entered into Parliament at a young age of 30 years as an independent member in Lok Sabha from the Jodhpur constituency and made a great contribution in the parliamentary proceedings and discussions. The contents of the present volume are divided into two parts. Part 1 deals with the biographical account of Dr L.M. Singhvi which covers many phases of his life journey and contributions. Part 2 contains a number of unpublished papers of Dr Singhvi which are thematically organized in three different sections. Sections of this part deal with Dr Singhvi’s academic writings on issues pertaining to public governance and administration.

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Epistemic Injustice and Indigenous Women: Toward Centering Indigeneity in Social Work

Affilia ◽

10.1177/0886109920985265 ◽

2021 ◽

pp. 088610992098526

Author(s):

Marjorie Johnstone ◽

Eunjung Lee

Keyword(s):

Social Workers ◽

Indigenous Women ◽

Epistemic Injustice ◽

Feminist Activism ◽

Indigenous Resistance ◽

Systemic Analysis ◽

Life Journey ◽

Women And Girls ◽

Miranda Fricker ◽

Individual Perspective

Using the theoretical framework of epistemic injustice articulated by philosopher Miranda Fricker as an analytic tool, we analyze recent victories of Indigenous feminist activism in gathering the stories of Indigenous women, challenging dominant meta-narratives and rewriting the herstory of Canada. We use the epistemic concept of the hermeneutic gap to consider the implications of this resistance in conjunction with the increased visibility of the intersectional positionality of Indigenous women. To illustrate our analysis, we focus on two case studies. Firstly, an individual perspective through the life journey of a feminist Anishinaabe Activist, Bridgett Perrier. Secondly, we conduct a systemic analysis of the recent Report on the National Inquiry into the Missing and Murdered Indigenous Women and Girls (MMIWG). We close with a discussion on how critical it is for social workers—especially non-Indigenous social workers—to relearn and document the meaning of the MMIWG issues. This includes recognizing Indigenous resistance, activism, and the newly formulated hermeneutic understandings that are emerging. Then, the final task is to apply these concepts to their practice and heed the calls to action which the report calls for.

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Fatal Attraction: The Case of Toxic Soluble Dimers of Truncated PQBP-1 Mutants in X-Linked Intellectual Disability

International Journal of Molecular Sciences ◽

10.3390/ijms22052240 ◽

2021 ◽

Vol 22 (5) ◽

pp. 2240

Author(s):

Yu Wai Chen ◽

Shah Kamranur Rahman

Keyword(s):

Intellectual Disability ◽

Rna Splicing ◽

Intrinsically Disordered Proteins ◽

Cognitive Disorder ◽

Disordered Proteins ◽

Thermal Stabilities ◽

Conformational Disease ◽

Intrinsically Disordered ◽

Fatal Attraction ◽

Experimental Characterisation

The frameshift mutants K192Sfs*7 and R153Sfs*41, of the polyglutamine tract-binding protein 1 (PQBP-1), are stable intrinsically disordered proteins (IDPs). They are each associated with the severe cognitive disorder known as the Renpenning syndrome, a form of X-linked intellectual disability (XLID). Relative to the monomeric wild-type protein, these mutants are dimeric, contain more folded contents, and have higher thermal stabilities. Comparisons can be drawn to the toxic oligomerisation in the “conformational diseases”, which collectively describe medical conditions involving a substantial protein structural transition in the pathogenic mechanism. At the molecular level, the end state of these diseases is often cytotoxic protein aggregation. The conformational disease proteins contain varying extents of intrinsic disorder, and the consensus pathogenesis includes an early oligomer formation. We reviewed the experimental characterisation of the toxic oligomers in representative cases. PQBP-1 mutant dimerisation was then compared to the oligomerisation of the conformational disease proteins. The PQBP-1 mutants are unique in behaving as stable soluble dimers, which do not further develop into higher oligomers or aggregates. The toxicity of the PQBP-1 mutant dimers lies in the native functions (in transcription regulation and possibly, RNA splicing) being compromised, rather than proceeding to aggregation. Other examples of stable IDP dimers were discussed and we speculated on the roles of IDP dimerisation in protein evolution.

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