scholarly journals Skeletal muscle assessment in critically ill patients：Methods and application

2021 ◽  
Vol 55 (6) ◽  
pp. 273-280
Author(s):  
Kohei Tanaka ◽  
Sho Katayama ◽  
Kazuki Okura ◽  
Masatsugu Okamura ◽  
Keishi Nawata ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Critically Ill

Myopathy and Neuropathy Acquired in the Intensive Care Unit

2019 ◽  
pp. 677-684
Author(s):  
Priya S. Dhawan ◽  
Jennifer A. Tracy
Keyword(s):  
Skeletal Muscle ◽  
Intensive Care Unit ◽  
At Risk ◽  
Intensive Care ◽  
Peripheral Neuropathy ◽  
Critical Illness ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Critical Illness Polyneuropathy ◽  
Muscle Disorder

Acquired weakness in critically ill patients is common, affecting between one-third to one-half of patients in the intensive care unit (ICU). Exposure to simultaneous stressors such as metabolic derangements, fluid and electrolyte shifts, infection, catabolic stress, and medications put patients in the ICU at risk for damage to both nerve and skeletal muscle with substantial and often lasting morbidity. Critical illness polyneuropathy is a length-dependent, axonal peripheral neuropathy occurring in patients in the ICU and unrelated to the primary illness. Critical illness myopathy is an ICU-associated muscle disorder occurring independently of denervation and uniquely identified by electrophysiologic and histologic characteristics.

scholarly journals Early high protein intake and mortality in critically ill ICU patients with low skeletal muscle area and -density

2020 ◽  
Vol 39 (7) ◽  
pp. 2192-2201 ◽  
Author(s):  
Wilhelmus G.P.M. Looijaard ◽  
Ingeborg M. Dekker ◽  
Albertus Beishuizen ◽  
Armand R.J. Girbes ◽  
Heleen M. Oudemans-van Straaten ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Critically Ill ◽  
Protein Intake ◽  
High Protein ◽  
Muscle Area ◽  
Icu Patients ◽  
High Protein Intake ◽  
Skeletal Muscle Area

A descriptive study of skeletal muscle metabolism in critically ill patients

1996 ◽  
Vol 24 (4) ◽  
pp. 575-583 ◽  
Author(s):  
Lena Gamrin ◽  
Pia Essen ◽  
Ann Marie Forsberg ◽  
Eric Hultman ◽  
Jan Wernerman
Keyword(s):  
Skeletal Muscle ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Muscle Metabolism ◽  
Descriptive Study ◽  
Skeletal Muscle Metabolism

scholarly journals Skeletal muscle strength in critically ill patients

Critical Care ◽  
10.1186/cc577 ◽  
1999 ◽  
Vol 3 (Suppl 1) ◽  
pp. P204
Author(s):  
ML Harris ◽  
C-H Hamnegard ◽  
MI Polkey ◽  
J Moxham
Keyword(s):  
Skeletal Muscle ◽  
Muscle Strength ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Skeletal Muscle Strength

scholarly journals Expression of thyroid hormone transporters during critical illness

2009 ◽  
Vol 161 (2) ◽  
pp. 243-250 ◽  
Author(s):  
Liese Mebis ◽  
Deborah Paletta ◽  
Yves Debaveye ◽  
Björn Ellger ◽  
Lies Langouche ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Critical Illness ◽  
Thyroid Hormone ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Rabbit Model ◽  
Monocarboxylate Transporter ◽  
Expression Levels ◽  
Gene Expression Levels

ObjectiveProlonged critically ill patients have low circulating thyroid hormone (TH) levels without a rise in TSH, a condition labeled ‘the low tri-iodothyronine (T3) syndrome’. Currently, it is not clear whether this represents an adaptive response. We examined the role of TH transporters monocarboxylate transporter 8 (MCT8, also known as SLC16A2) and MCT10 in the pathogenesis of the low T3 syndrome in prolonged critical illness.MethodsA clinical observational study in critically ill patients and an intervention study in an in vivo animal model of critical illness. Gene expression levels of MCT8 and MCT10 were measured by real-time PCR.ResultsIn prolonged critically ill patients, we measured increased MCT8 but not MCT10 gene expression levels in liver and skeletal muscle as compared with patients undergoing acute surgical stress. In a rabbit model of prolonged critical illness, gene expression levels of MCT8 in liver and of MCT10 in skeletal muscle were increased as compared with healthy controls. Treatment of prolonged critically ill rabbits with TH (thyroxine+T3) resulted in a downregulation of gene expression levels of MCT8 in liver and of MCT10 in muscle. Transporter expression levels correlated inversely with circulating TH parameters.ConclusionsThese data suggest that alterations in the expression of TH transporters do not play a major role in the pathogenesis of the ‘low T3 syndrome’ but rather reflect a compensatory effort in response to hypothyroidism.

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