CCR7 Deficiency Enhances Hematopoietic Stem Cell And Myeloid Progenitor Cell Proliferation And Ameliorates Susceptibility To Invasive Pulmonary Aspergillosis Following Hematopoietic Stem Cell Transplantation

Invasive pulmonary aspergillosis is a frequent complication in immunocompromised individuals, and it continues to be an important cause of mortality in patients undergoing hematopoietic stem cell transplantation. In addition to antifungal therapy used for mycoses, immune-modulatory molecules such as cytokines and chemokines can modify the host immune response and exhibit a promising form of antimicrobial therapeutics to combat invasive fungal diseases. Cytokine and chemokine profiles may also be applied as biomarkers during fungal infections and clinical research has demonstrated different activation patterns of cytokines in invasive mycoses such as aspergillosis. In this review, we summarize different aspects of cytokines that have been described to date and provide possible future directions in research on invasive pulmonary aspergillosis following hematopoietic stem cell transplantation. These findings suggest that cytokines and chemokines may serve as useful biomarkers to improve diagnosis and monitoring of infection.

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Influence of PI-3K/Akt pathway on Wnt signalling in regulating myeloid progenitor cell proliferation. Evidence for a role of autocrine/paracrine Wnt regulation

British Journal of Haematology ◽

10.1111/j.1365-2141.2009.07823.x ◽

2009 ◽

Vol 146 (6) ◽

pp. 637-651 ◽

Cited By ~ 13

Author(s):

Georgios Nteliopoulos ◽

Stephen B. Marley ◽

Myrtle Y. Gordon

Keyword(s):

Cell Proliferation ◽

Progenitor Cell ◽

Wnt Signalling ◽

Akt Pathway ◽

Myeloid Progenitor ◽

Myeloid Progenitor Cell ◽

Progenitor Cell Proliferation

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THE ROLE OF BRONCHOSCOPY IN DIAGNOSIS INVASIVE PULMONARY ASPERGILLOSIS IN CHILDREN AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

Russian Journal of Pediatric Hematology and Oncology ◽

10.17650/2311-1267-2015-2-2-72-76 ◽

2015 ◽

Vol 2 (2) ◽

pp. 72 ◽

Cited By ~ 2

Author(s):

A. G. Volkova ◽

M. O. Popova ◽

K. A. Ekushev ◽

I. R. Zinnatullin ◽

I. Yu. Nikolaev ◽

...

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell Transplantation ◽

Stem Cell Transplantation ◽

Cell Transplantation ◽

Hematopoietic Stem Cell ◽

Invasive Pulmonary Aspergillosis ◽

Pulmonary Aspergillosis ◽

Hematopoietic Stem

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Combination antifungal therapy and surgery for the treatment of invasive pulmonary aspergillosis after hematopoietic stem cell transplantation

Pediatric Reports ◽

10.4081/pr.2011.e18 ◽

2011 ◽

Vol 3 (3) ◽

pp. 18 ◽

Cited By ~ 1

Author(s):

Simone Cesaro ◽

Marta Pillon ◽

Elisabetta Calore ◽

Rita Alaggio ◽

Piergiorgio Gamba ◽

...

Keyword(s):

Stem Cell ◽

Hematopoietic Stem Cell ◽

Antifungal Therapy ◽

Hematopoietic Stem Cell Transplant ◽

Stem Cell Transplant ◽

Invasive Pulmonary Aspergillosis ◽

Cell Transplant ◽

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Pulmonary Aspergillosis ◽

Hematopoietic Stem

An 8-year old boy, affected by severe aplastic anemia, developed a probable pulmonary invasive aspergillosis (IA) early after a second unrelated allogeneic hematopoietic stem cell transplant (HSCT). He was treated promptly with the combination of liposomal amphotericin B and caspofungin. Despite the initial stabilization, the patient deteriorated and the antifungal therapy was switched to voriconazole and caspofungin. The patient gradually improved and was discharged home on day +29 post-HSCT on oral voriconazole. On day +119, a sudden episode of hemoptysis occurred and a right superior lobectomy was decided to remove the residual aspergilloma. The patient is now alive and well more than 24 months from HSCT. This case demonstrated that antifungal combination therapy and surgery are valid options to cure pulmonary IA even in patients at high-risk and severely immunosuppressed.

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