Single Breath Diffusing Capacity For Carbon Monoxide And Nitric Oxide Measured In Children With Various Cardiac And Pulmonary Diseases

2012 ◽  
Author(s):  
Astrid B. Thomas ◽  
Frederik Buchvald ◽  
Birgitte Hanel ◽  
Lars Idorn ◽  
Kim G. Nielsen
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Pulmonary Diseases ◽  
Diffusing Capacity ◽  
Single Breath

scholarly journals Reference equations for pulmonary diffusing capacity of carbon monoxide and nitric oxide in adult Caucasians

2018 ◽  
Vol 52 (1) ◽  
pp. 1500677 ◽  
Author(s):  
Mathias Munkholm ◽  
Jacob Louis Marott ◽  
Lars Bjerre-Kristensen ◽  
Flemming Madsen ◽  
Ole Find Pedersen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Hold Time ◽  
Specific Conductance ◽  
Breath Hold ◽  
Diffusing Capacity ◽  
Single Breath ◽  
Capillary Membrane ◽  
Reference Equations ◽  
Hb Concentration

The aim of this study was to determine reference equations for the combined measurement of diffusing capacity of the lung for carbon monoxide (CO) and nitric oxide (NO) (DLCONO). In addition, we wanted to appeal for consensus regarding methodology of the measurement including calculation of diffusing capacity of the alveolo-capillary membrane (Dm) and pulmonary capillary volume (Vc).DLCONO was measured in 282 healthy individuals aged 18–97 years using the single-breath technique and a breath-hold time of 5 s (true apnoea period). The following values were used: 1) specific conductance of nitric oxide (θNO)=4.5 mLNO·mLblood−1·min−1·mmHg−1; 2) ratio of diffusing capacity of the membrane for NO and CO (DmNO/DmCO)=1.97; and 3) 1/red cell CO conductance (1/θCO)=(1.30+0.0041·mean capillary oxygen pressure)·(14.6/Hb concentration in g·dL−1).Reference equations were established for the outcomes of DLCONO, including DLCO and DLNO and the calculated values Dm and Vc. Independent variables were age, sex, height and age squared.By providing new reference equations and by appealing for consensus regarding the methodology, we hope to provide a basis for future studies and clinical use of this novel and interesting method.

The effect of conductive ventilation heterogeneity on diffusing capacity measurement

2008 ◽  
Vol 104 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Sylvia Verbanck ◽  
Daniel Schuermans ◽  
Sophie Van Malderen ◽  
Walter Vincken ◽  
Bruce Thompson
Keyword(s):  
Carbon Monoxide ◽  
Vital Capacity ◽  
Experimental Situation ◽  
Normal Subjects ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
Alveolar Volume ◽  
Estimation Errors ◽  
Single Breath ◽  
Ventilation Heterogeneity

It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and related the resulting changes in conductive ventilation heterogeneity (derived from the multiple-breath washout test) to corresponding changes in diffusing capacity, alveolar volume, and inspired vital capacity (derived from the single-breath DlCO method). Average conductive ventilation heterogeneity doubled ( P < 0.001), whereas DlCO decreased by 6% ( P < 0.001), with no correlation between individual data ( P > 0.1). Average inspired vital capacity and alveolar volume both decreased significantly by, respectively, 6 and 3%, and the individual changes in alveolar volume and in conductive ventilation heterogeneity were correlated ( r = −0.46; P = 0.006). These findings can be brought in agreement with recent modeling work, where specific ventilation heterogeneity resulting from different distributions of either inspired volume or end-expiratory lung volume have been shown to affect DlCO estimation errors in opposite ways. Even in the presence of flow asynchrony, these errors appear to largely cancel out in our experimental situation of histamine-induced conductive ventilation heterogeneity. Finally, we also predicted which alternative combination of specific ventilation heterogeneity and flow asynchrony could affect DlCO estimate in a more substantial fashion in diseased lungs, irrespective of any diffusion-dependent effects.

Single Breath Carbon Monoxide Diffusing Capacity

1988 ◽  
Vol 137 (5) ◽  
pp. 1244-1244
Author(s):  
Edith Rosenberg ◽  
Margaret R. Becklake
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Single Breath

scholarly journals Impact of atrial septal defect closure on diffusing capacity for nitric oxide and carbon monoxide

2019 ◽  
Vol 5 (2) ◽  
pp. 00260-2018 ◽  
Author(s):  
Martina Nassif ◽  
Reindert P. van Steenwijk ◽  
Ivo van der Lee ◽  
Peter J. Sterk ◽  
Frans H.C. de Jongh ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Atrial Septal Defect ◽  
Septal Defect ◽  
Defect Closure ◽  
Diffusing Capacity ◽  
Atrial Septal Defect Closure

The value of diffusing capacity for nitric oxide and carbon monoxide in sickle cell disease

2015 ◽  
Author(s):  
Arnaud Chambellan ◽  
Stephanie Dirou ◽  
Berangere Ricolleau ◽  
Julie Graveleau ◽  
Agathe Masseau
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Diffusing Capacity ◽  
Cell Disease

scholarly journals 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

2017 ◽  
Vol 49 (1) ◽  
pp. 1600016 ◽  
Author(s):  
Brian L. Graham ◽  
Vito Brusasco ◽  
Felip Burgos ◽  
Brendan G. Cooper ◽  
Robert Jensen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Recent Literature ◽  
American Thoracic Society ◽  
Common Type ◽  
Diffusing Capacity ◽  
Tracer Gas ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Single Breath ◽  
The World

This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both DLCO (diffusing capacity) and TLCO (transfer factor) are valid terms to describe the uptake of carbon monoxide in the lung, the term DLCO is used in this document. A joint taskforce appointed by the ERS and ATS reviewed the recent literature on the measurement of DLCO and surveyed the current technical capabilities of instrumentation being manufactured around the world. The recommendations in this document represent the consensus of the taskforce members in regard to the evidence available for various aspects of DLCO measurement. Furthermore, it reflects the expert opinion of the taskforce members on areas in which peer-reviewed evidence was either not available or was incomplete. The major changes in these technical standards relate to DLCO measurement with systems using rapidly responding gas analysers for carbon monoxide and the tracer gas, which are now the most common type of DLCO instrumentation being manufactured. Technical improvements and the increased capability afforded by these new systems permit enhanced measurement of DLCO and the opportunity to include other optional measures of lung function.

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