Retrospectroscope: The single breath test of diffusing capacity for carbon monoxide

1977 ◽  
Vol 3 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Edith Rosenberg
Keyword(s):  
Carbon Monoxide ◽  
Breath Test ◽  
Diffusing Capacity ◽  
Single Breath ◽  
Single Breath Test

The effect of conductive ventilation heterogeneity on diffusing capacity measurement

2008 ◽  
Vol 104 (4) ◽  
pp. 1094-1100 ◽  
Author(s):  
Sylvia Verbanck ◽  
Daniel Schuermans ◽  
Sophie Van Malderen ◽  
Walter Vincken ◽  
Bruce Thompson
Keyword(s):  
Carbon Monoxide ◽  
Vital Capacity ◽  
Experimental Situation ◽  
Normal Subjects ◽  
Diffusing Capacity ◽  
Capacity Measurement ◽  
Alveolar Volume ◽  
Estimation Errors ◽  
Single Breath ◽  
Ventilation Heterogeneity

It has long been assumed that the ventilation heterogeneity associated with lung disease could, in itself, affect the measurement of carbon monoxide transfer factor. The aim of this study was to investigate the potential estimation errors of carbon monoxide diffusing capacity (DlCO) measurement that are specifically due to conductive ventilation heterogeneity, i.e., due to a combination of ventilation heterogeneity and flow asynchrony between lung units larger than acini. We induced conductive airway ventilation heterogeneity in 35 never-smoker normal subjects by histamine provocation and related the resulting changes in conductive ventilation heterogeneity (derived from the multiple-breath washout test) to corresponding changes in diffusing capacity, alveolar volume, and inspired vital capacity (derived from the single-breath DlCO method). Average conductive ventilation heterogeneity doubled ( P < 0.001), whereas DlCO decreased by 6% ( P < 0.001), with no correlation between individual data ( P > 0.1). Average inspired vital capacity and alveolar volume both decreased significantly by, respectively, 6 and 3%, and the individual changes in alveolar volume and in conductive ventilation heterogeneity were correlated ( r = −0.46; P = 0.006). These findings can be brought in agreement with recent modeling work, where specific ventilation heterogeneity resulting from different distributions of either inspired volume or end-expiratory lung volume have been shown to affect DlCO estimation errors in opposite ways. Even in the presence of flow asynchrony, these errors appear to largely cancel out in our experimental situation of histamine-induced conductive ventilation heterogeneity. Finally, we also predicted which alternative combination of specific ventilation heterogeneity and flow asynchrony could affect DlCO estimate in a more substantial fashion in diseased lungs, irrespective of any diffusion-dependent effects.

Single Breath Carbon Monoxide Diffusing Capacity

1988 ◽  
Vol 137 (5) ◽  
pp. 1244-1244
Author(s):  
Edith Rosenberg ◽  
Margaret R. Becklake
Keyword(s):  
Carbon Monoxide ◽  
Diffusing Capacity ◽  
Single Breath

scholarly journals 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung

2017 ◽  
Vol 49 (1) ◽  
pp. 1600016 ◽  
Author(s):  
Brian L. Graham ◽  
Vito Brusasco ◽  
Felip Burgos ◽  
Brendan G. Cooper ◽  
Robert Jensen ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Recent Literature ◽  
American Thoracic Society ◽  
Common Type ◽  
Diffusing Capacity ◽  
Tracer Gas ◽  
European Respiratory Society ◽  
Technical Standards ◽  
Single Breath ◽  
The World

This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both DLCO (diffusing capacity) and TLCO (transfer factor) are valid terms to describe the uptake of carbon monoxide in the lung, the term DLCO is used in this document. A joint taskforce appointed by the ERS and ATS reviewed the recent literature on the measurement of DLCO and surveyed the current technical capabilities of instrumentation being manufactured around the world. The recommendations in this document represent the consensus of the taskforce members in regard to the evidence available for various aspects of DLCO measurement. Furthermore, it reflects the expert opinion of the taskforce members on areas in which peer-reviewed evidence was either not available or was incomplete. The major changes in these technical standards relate to DLCO measurement with systems using rapidly responding gas analysers for carbon monoxide and the tracer gas, which are now the most common type of DLCO instrumentation being manufactured. Technical improvements and the increased capability afforded by these new systems permit enhanced measurement of DLCO and the opportunity to include other optional measures of lung function.

Single Breath Carbon Monoxide Diffusing Capacity (Transfer Factor): Reply

1988 ◽  
Vol 138 (4) ◽  
pp. 1084-1085 ◽  
Author(s):  
Robert O. Crapo ◽  
Reed M. Gardner ◽  
Steven L. Berlin
Keyword(s):  
Carbon Monoxide ◽  
Transfer Factor ◽  
Diffusing Capacity ◽  
Single Breath

scholarly journals Changes in Lung Diffusing Capacity of Elite Artistic Swimmers During Training

2020 ◽  
Author(s):  
Iker García ◽  
Franchek Drobnic ◽  
Victoria Pons ◽  
Ginés Viscor
Keyword(s):  
Carbon Monoxide ◽  
Repeated Measures ◽  
Significant Interaction ◽  
Physiological Responses ◽  
Individual Variability ◽  
Diffusing Capacity ◽  
Repeated Measures Anova ◽  
National Team ◽  
Single Breath ◽  
Single Breath Method

AbstractArtistic swimmers (AS) are exposed to repeated apnoeas in the aquatic environment during high intensity exercise provoking specific physiological responses to training, apnoea, and immersion. This study aimed to evaluate the changes in lung diffusing capacity in AS pre-, mid- and post-training in a combined session of apnoeic swimming, figures and choreography. Eleven elite female AS from the Spanish national team were the study’s participants. The single-breath method was used to measure lung diffusing capacity for carbon monoxide (DLCO) and one-way repeated measures ANOVA was utilized to evaluate the statistical analysis. Basal values of DLCO were higher than normal for their age and height (33.6±4.9 mL·min−1·mmHg−1; 139±19%) and there were a significant interaction between DLCO and AS training (ŋ2 p=0.547). After the apnoeic swimming (mid-training) there was an increase in DLCO from basal to 36.7±7.3 mL·min−1·mmHg−1 (p=0.021), and after the figures and choreography (post-training) there was a decrease compared to mid-training (32.3±4.6 mL·min−1·mmHg−1, p=0.013). Lung diffusing capacity changes occur during AS training, including a large increase after apnoeic swimming. There were no differences in lung diffusing capacity from pre- to post-training, although large inter-individual variability was observed.

Single-breath test in lateral decubitus reflects function of single lungs grafted for emphysema

2006 ◽  
Vol 100 (3) ◽  
pp. 834-838 ◽  
Author(s):  
Alain Van Muylem ◽  
Pietro Scillia ◽  
Christiane Knoop ◽  
Manuel Paiva ◽  
Marc Estenne
Keyword(s):  
Lung Transplantation ◽  
Computerized Tomography ◽  
Breath Test ◽  
Transplant Recipients ◽  
Single Lung Transplantation ◽  
Single Breath ◽  
Native Lung ◽  
Single Breath Test ◽  
Lateral Decubitus ◽  
Normal Controls

The slope of alveolar plateau for nitrogen derived from the single-breath test is useful to assess the function of bilateral lung grafts, but this technique is not applicable to patients with single-lung grafts due to the confounding influence of the native lung. We tested the hypothesis that the nitrogen slope measured in lateral decubitus with the graft in nondependent position may primarily reflect the distribution of ventilation in this lung. Fifteen patients with single-lung transplantation for emphysema, 10 healthy controls, and 7 patients with advanced emphysema performed single-breath washouts in right and left lateral decubitus; nitrogen slope was measured between 75 and 100% of expired volume. In 10 transplant recipients, the volume of each lung was measured in the two postures by computerized tomography. Nitrogen slope was unaffected by posture in normal controls and emphysema patients. On the other hand, nitrogen slope in transplant recipients was invariably smaller, with the graft in nondependent vs. in dependent position. Values of nitrogen slope with the graft in nondependent position were similar to those obtained in normal controls but significantly smaller than those obtained in emphysema patients. Computerized tomography studies in this position indicated that the volume expired below functional residual capacity was exclusively contributed by the graft. We conclude that, in patients with single-lung transplantation for emphysema, 1) measuring nitrogen slope in lateral decubitus allows to distinguish between the graft and the native lung, and 2) nitrogen slope obtained with the graft in nondependent position reflects ventilation distribution in this lung.

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