scholarly journals Selexipag Use: Characterization of the First 500 Patients (pts) in SPHERE (SelexiPag: tHe usErs dRug rEgistry) by World Health Organization (WHO) Functional Class (FC)

2020 ◽  
Author(s):  
M.M. Chakinala ◽  
H.W. Farber ◽  
V.V. McLaughlin ◽  
A.R. Hemnes ◽  
N.H. Kim ◽  
...  
Keyword(s):  
World Health Organization ◽  
Functional Class ◽  
World Health ◽  
Drug Registry ◽  
Health Organization

scholarly journals Riociguat treatment for portopulmonary hypertension: a subgroup analysis from the PATENT-1/-2 studies

2018 ◽  
Vol 8 (2) ◽  
pp. 204589401876930 ◽  
Author(s):  
Rodrigo Cartin-Ceba ◽  
Michael Halank ◽  
Hossein-Ardeschir Ghofrani ◽  
Marc Humbert ◽  
John Mattson ◽  
...  
Keyword(s):  
World Health Organization ◽  
Subgroup Analysis ◽  
Functional Class ◽  
World Health ◽  
Walking Distance ◽  
Portopulmonary Hypertension ◽  
Open Label ◽  
Open Label Extension ◽  
Efficacy Parameters ◽  
Health Organization

In patients with portopulmonary hypertension (n = 13) included in the 12-week randomized placebo-controlled PATENT-1 trial, riociguat was well tolerated and improved 6-min walking distance (6MWD), World Health Organization functional class (WHO FC), and other efficacy parameters; 6MWD and WHO FC improvements were sustained over two years in the open-label extension, PATENT-2.

scholarly journals Liver transplantation in a patient with hereditary haemorrhagic telangiectasia and pulmonary hypertension

2019 ◽  
Vol 9 (4) ◽  
pp. 204589401989667
Author(s):  
Kentaro Ejiri ◽  
Satoshi Akagi ◽  
Kazufumi Nakamura ◽  
Naofumi Amioka ◽  
Keishi Ichikawa ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Pulmonary Hypertension ◽  
World Health Organization ◽  
Arteriovenous Malformations ◽  
Functional Class ◽  
Arteriovenous Shunt ◽  
World Health ◽  
Right Atrial ◽  
Hereditary Haemorrhagic Telangiectasia ◽  
Health Organization

Hereditary haemorrhagic telangiectasia or Rendu-Osler-Weber syndrome is a systemic vascular disease with autosomal dominant inheritance, mucocutaneous telangiectasia, and repeated nasal bleeding due to vascular abnormalities. Hereditary haemorrhagic telangiectasia may occasionally lead to complications, including arteriovenous malformations and pulmonary hypertension. We present a case of a 52-year-old female patient with hereditary haemorrhagic telangiectasia who was referred to our hospital for treatment of pulmonary hypertension. She had been diagnosed with hereditary haemorrhagic telangiectasia during adolescence and was being followed up. Six months prior to presentation, she had undergone coil embolization for pulmonary haemorrhage due to pulmonary arteriovenous malformations. She was in World Health Organization functional class IV, with a mean of pulmonary arterial pressure of 38 mmHg, a pulmonary capillary wedge pressure of 10 mmHg, and a right atrial pressure of 22 mmHg. A contrast-enhanced computed tomography angiography showed large arteriovenous malformations in the liver. Right heart catheterization revealed an increase in oxygen saturation in the inferior vena cava between the supra- and infra-hepatic veins, low pulmonary vascular resistance, and high right atrial pressure. Hence, she was diagnosed with hereditary haemorrhagic telangiectasia with pulmonary hypertension due to major arteriovenous shunt resulting from arteriovenous malformations in the liver. Therefore, we considered liver transplantation as an essential treatment option. She underwent cadaveric liver transplantation after a year resulting in dramatic haemodynamic improvement to World Health Organization functional class I. Liver transplantation is a promising treatment in patients with hereditary haemorrhagic telangiectasia and pulmonary hypertension resulting from arteriovenous shunt caused by arteriovenous malformations in the liver.

Epidemology: The role of the World Health Organization in the study of influenza

1980 ◽  
Vol 288 (1029) ◽  
pp. 417-421 ◽  
Keyword(s):  
World Health Organization ◽  
Diagnostic Procedures ◽  
Early Years ◽  
World Health ◽  
Isolation And Characterization ◽  
The World ◽  
Pandemic Strains ◽  
Health Organization

The World Health Organization (W.H.O.), since its inception in 1947, has given close attention to influenza. In its early years W.H.O. laid the foundations of its present network of over 100 national influenza centres and collaborating laboratories which today constitute the backbone of its influenza activities. The activities of the network include the isolation and characterization of influenza strains and the early notification of any changes in surface antigens, the preparation of reference reagents, standardization of diagnostic procedures, formulation of requirements for vaccines, training, and collaboration in research. The efficacy of the network has been proved in the 1957, 1968 and 1977 epidemics. Collaborative research organized by W.H.O. has made important contributions to our understanding of the epidemiology of influenza, including the possible role of lower animals as the origin of some pandemic strains. The latter subject is briefly discussed.

Distribution of Phytochemicals and Some Anti-nutrients in Selected Edible Mushrooms in Ekiti State, Nigeria

2018 ◽  
Vol 4 (09) ◽  
Author(s):  
Adedeji Olayinka Adebiyi
Keyword(s):  
Secondary Metabolites ◽  
World Health Organization ◽  
Nutritional Composition ◽  
Edible Mushrooms ◽  
World Health ◽  
Total Phenols ◽  
Mushroom Species ◽  
Safe Limits ◽  
Health Organization

The present study was carried out to determine the phytochemical and anti nutritional composition of some selected edible mushrooms collected in Ekiti State, Nigeria such as Pleurotus sajor-caju, Termitomyces robustus, Lentinus squarosullus, Termitomyces microcarpous, Termitomyces clypeatus, Lentinus tuber-regium and Polyporus sp. The results of phytochemical analyses revealed the presence of phytochemicals such as alkaloids (0.03-0.17%), saponin (0.03-0.12%), total phenols (0.12-4.32%), flavonoids (0.20-6.04%) and tannins (0.04-2.60%). The least concentration of all the phytochemicals was found in Polyporus sp. Results of anti nutrient screening revealed the presence of phytate (0.17-0.34mg/g), oxalate (1.87-4.04mg/g) and cyanide (0.05-0.27mg/g). Furthermore, results revealed significant differences in the phytochemical as well as anti nutritional composition of the mushrooms though some species had similar compositions. The obtained values of phytochemicals and anti nutrients were significantly lower in all the mushroom species compared to their toxic levels according to World Health Organization stipulated safe limits. Thus, the study suggests that all the mushroom species are very safe for consumption while the presence of alkaloids, saponins, phenols and flavonoids indicate medicinal potentials. Hence, screening and characterization of the secondary metabolites are required.

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