Factors Associated with Persistence of Severe Asthma from Late Adolescence to Early Adulthood

Author(s):  
Neema Izadi ◽  
David Baraghoshi ◽  
Douglas Curran-Everett ◽  
Robert S. Zeiger ◽  
Stanley J Szefler ◽  
...  
2020 ◽  
Vol 145 (2) ◽  
pp. AB161
Author(s):  
Neema Izadi ◽  
Douglas Curran-Everett ◽  
Robert Zeiger ◽  
Stanley Szefler ◽  
Ronina Covar

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Mohsen Sadatsafavi ◽  
Amir Khakban ◽  
Hamid Tavakoli ◽  
Solmaz Ehteshami-Afshar ◽  
Larry D. Lynd ◽  
...  

Abstract Background Oral corticosteroids are important components of pharmacotherapy in severe asthma. Our objective was to describe the extent, trends, and factors associated with exposure to oral corticosteroids (OCS) in a severe asthma cohort. Methods We used administrative health databases of British Columbia, Canada (2000–2014) and validated algorithms to retrospectively create a cohort of severe asthma patients. Exposure to OCS within each year of follow-up was measured in two ways: maintenance use as receiving on average ≥ 2.5 mg/day (prednisone-equivalent) OCS, and episodic use as the number of distinct episodes of OCS exposure for up to 14 days. Trends and factors associated with exposure on three time axes (calendar year, age, and time since diagnosis) were evaluated using Poisson regression. Results 21,144 patients (55.4% female; mean entry age 28.7) contributed 40,803 follow-up years, in 8.2% of which OCS was used as maintenance therapy. Maintenance OCS use declined by 3.8%/calendar year (p < 0.001). The average number of episodes of OCS use was 0.89/year, which increased by 1.1%/calendar year (p < 0.001). Trends remained significant for both exposure types in adjusted analyses. Both maintenance and episodic use increased by age and time since diagnosis. Conclusions This population-based study documented a secular downward trend in maintenance OCS use in a period before widespread use of biologics. This might have been responsible for a higher rate of exacerbations that required episodic OCS therapy. Such trends in OCS use might be due to changes in the epidemiology of severe asthma, or changes in patient and provider preferences over time.


2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Trine Pagh Pedersen ◽  
Bjørn E Holstein ◽  
Esben Meulengracht Flachs ◽  
Mette Rasmussen

1987 ◽  
Vol 64 (1) ◽  
pp. 117-118 ◽  
Author(s):  
Bill McLeod

Three groups of 120 male and female students each, aged 13 to 15 yr., 16 to 18 yr., and 19 to 21 yr., were tested on Oilman's portable rod-and-frame apparatus to assess field dependence. Analysis indicated that the 16- to 18-yr.-old group was more field independent. Developmental trends indicated decreased field-dependence into late adolescence, and then a reversal indicating an increase in field-dependence beginning in early adulthood (19- to 21-yr.-old group).


2010 ◽  
Vol 47 (2) ◽  
pp. 124-130 ◽  
Author(s):  
Juan Luis Rodriguez Hermosa ◽  
Carlos Barcina Sánchez ◽  
Myriam Calle Rubio ◽  
Mercedes Muñoz Mínguez ◽  
Jose Luis Alvarez-Sala Walther

2010 ◽  
Vol 22 (4) ◽  
pp. 917-932 ◽  
Author(s):  
Jeremy Staff ◽  
John E. Schulenberg ◽  
Julie Maslowsky ◽  
Jerald G. Bachman ◽  
Patrick M. O'Malley ◽  
...  

AbstractSubstance use changes rapidly during late adolescence and early adulthood. This time in the life course is also dense with social role changes, as role changes provide dynamic context for individual developmental change. Using nationally representative, multiwave longitudinal data from age 18 to 28, we examine proximal links between changes in social roles and changes in substance use during the transition to adulthood. We find that changes in family roles, such as marriage, divorce, and parenthood, have clear and consistent associations with changes in substance use. With some notable exceptions, changes in school and work roles have weaker effects on changes in substance use compared to family roles. Changes in socializing (i.e., nights out for fun and recreation) and in religiosity were found to mediate the relationship of social role transitions to substance use. Two time-invariant covariates, socioeconomic background and heavy adolescent substance use, predicted social role status, but did not moderate associations, as within-person links between social roles and substance use were largely equivalent across groups. This paper adds to the cascading effects literature by considering how, within individuals, more proximal variations in school, work, and family roles relate to variations in substance use, and which roles appear to be most influential in precipitating changes in substance use during the transition to adulthood.


Author(s):  
Jessica Craig ◽  
Alex R. Piquero

Emerging adulthood is a time of transition and identity development, largely between late adolescence and into early adulthood. During this period, individuals are navigating their new roles as adulthood ensues and, for some, antisocial behavior is part of this time period. This chapter highlights some of the main findings regarding the age–crime relationship, discusses some of the most central theories for understanding this relationship, and reviews the various punishment and rehabilitation strategies that have been applied to adolescent (and, very recently, emerging adulthood) offending. The authors identify gaps in the knowledge base, and possible avenues for both theoretical and empirical research are suggested.


PAIN Reports ◽  
2018 ◽  
Vol 3 (6) ◽  
pp. e700 ◽  
Author(s):  
Tracy Anastas ◽  
Kelsey Colpitts ◽  
Maisa Ziadni ◽  
Beth D. Darnall ◽  
Anna C. Wilson

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