Sensitization to Aspergillus Mix Among Atopic Sickle Cell Disease Patients in Abidjan, Côte d’Ivoire

Sickle cell disease is the most popular genetic disease in the world. In Côte d’Ivoire, the SCD prevalence is 12%. As such, SCD is a public health problem. Few studies are really investigating the relative levels of Th1, Th2 and Th17 types in black Africans and in the occurring of alloimmunization. This works attempts to identify the cytokine pattern produced by these patients during the course of the disease as Th1 cytokines, Th2 cytokines and Th17 and the relationship with alloimmunization. Patients and Methods: This is a prospective study followed at the National blood Transfusion Center in Abidjan, Côte d’Ivoire. Cytokines were measured by using Bio Legend’s LEGEND plexTM Human Inflammation Panel assays. We used Grifols DG gel® system to perform the immune hematology tests. Results: We recruit 50 patients with a diagnosis of sickle cell disease (SCD). Of these, only 31 have benefited from the research of irregular agglutinins (62%), comprising 14males (45.16%) and 17 females (54.84 %). The overall alloimmunization prevalence of 16.12%. The prevalence of alloimmunization was significantly greater in males than in females (60%). According to alloimmunization, we note an increased levels of IL-10 in non alloimmunized patients with SCD, when compared with alloimmunized and the levels of IL-4 was higher in alloimmunized patients compared to non alloimmunized. Lower IFN-γ levels were detected in non alloimmunized and alloimmunized SCD patients. Concerning IL-17, there was a small increase in patients without alloantibodies compared to those with. However no significant differences were noted in the 2 groups. Conclusion: The impact of biomarkers in the occurrence of alloimmunization is a constant preoccupation of researchers. Due to lack of financial aspect, small number of patients was enrolled. Even, we cannot draw any definitive conclusion; however our study brings data regarding the functioning of the immune system in SCD giving valuable insight.

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Feasibility Study of the “HemoTypeSC” Test for the Rapid Screening of Sickle Cell Disease in Côte D’Ivoire

Advances in Hematology ◽

10.1155/2021/8862039 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Jeannette Bassimbié Kakou Danho ◽

Yao Nicaise Atiméré ◽

Daouda Koné ◽

Donafologo Daouda Yéo ◽

Line Couitchéré

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Cote D'ivoire ◽

Côte D’Ivoire ◽

The Other ◽

Rapid Screening ◽

Cell Disease ◽

Cote D’Ivoire ◽

Hemoglobin S ◽

Côte D'ivoire

Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the population in West Africa and can reach 40% in Central Africa. In Côte d’Ivoire, the prevalence of the hemoglobin S is about 12–14% in the general population and about 11.71% in the child population in Abidjan. On the other hand, its coexistence with other hemoglobin phenotypes such as AC (6.2%) and β-thalassemia (2.7%) traits may also cause composite heterogeneous sickle cell disease, e.g., SC or S/β-thalassemia in this study. Since 2009, sickle cell disease has been recognized as a public health problem; however, much still remains to be performed despite the progress achieved. The objective of this study is thus to promote a rapid screening for the struggling against sickle cell disease in Côte d’Ivoire. This study was carried out over 6 months (April–September 2019) and has included 336 children, of which 236 all-comers, recruited in the municipality of Treichville in Abidjan and 100 other children with already known hemoglobin phenotype followed up in the Hematology Department of the University Hospital of Treichville. Two tests were used: the HemoTypeSC™ for rapid screening and the hemoglobin electrophoresis which is the reference method used for confirming the diagnosis in the laboratory. The findings confirmed the reliability of the HemoTypeSC™ with a sensitivity and specificity at 100% for the detection of hemoglobin A, S, and C. On the other hand, this sensitivity and specificity drop to 98.2% and 99.7%, respectively, when we analyze all the 336 children together, including the cases with HbF detected by hemoglobin electrophoresis. Hence, the importance of performing certainty tests following the HemoTypeSC™ screening test in order to determine the accurate phenotypes and proportions of the types of hemoglobin. The prevalence of hemoglobin S in subgroup 1 of 236 children of all-comers was 15%. The HemoTypeSC™ is therefore reliable, inexpensive, and disposable for rapid screening and early detection of sickle cell disease in Côte d’Ivoire. The HemoTypeSC™ provides rapid detection of hemoglobin phenotypes HbAA, HbSS, HbSC, HbCC, HbAS, and HbAC.

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Th1 and Th2 Cytokines Pattern among Sickle Cell Disease Patients in Côte d’ivoire

Clinical Immunology & Research ◽

10.33425/2639-8494.1011 ◽

2018 ◽

Vol 2 (1) ◽

Author(s):

Liliane K. Siransy ◽

Chiayé C.A. Yapo-Crézoit ◽

Maxime K. Diane ◽

Sidonie Goore ◽

Saydou Kaboré ◽

...

Keyword(s):

Sickle Cell Disease ◽

Sickle Cell ◽

Cote D'ivoire ◽

Côte D’Ivoire ◽

Th2 Cytokines ◽

Cell Disease ◽

Cote D’Ivoire ◽

Côte D'ivoire ◽

Th1 And Th2 Cytokines ◽

Th1 And Th2

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Anti-Erythrocyte Allo-Immunization to Sickle Cell Disease Patients Followed in Transfusion Therapy Unit of the National Blood Transfusion Center of Abidjan Côte D’Ivoire

International Journal of Immunology ◽

10.11648/j.iji.20170501.11 ◽

2017 ◽

Vol 5 (1) ◽

pp. 1 ◽

Cited By ~ 2

Author(s):

Sekongo Y. M.

Keyword(s):

Sickle Cell Disease ◽

Blood Transfusion ◽

Sickle Cell ◽

Cote D'ivoire ◽

Côte D’Ivoire ◽

Cell Disease ◽

Transfusion Therapy ◽

Cote D’Ivoire ◽

Transfusion Center ◽

Blood Transfusion Center

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Ethnobotanical study of medicinal plants used against sickle cell anaemia in the eastern part of the Côte d’Ivoire

Journal of Animal & Plant Sciences ◽

10.35759/janmplsci.v45-1.7 ◽

2020 ◽

Vol 45 (1) ◽

pp. 7839-7852

Author(s):

Akakpo-Akue J ◽

Kplé T.K.M ◽

Coulibaly Kiyinlma ◽

AHON Gnamien Marcel ◽

Fofié Yvette ◽

...

Keyword(s):

Sickle Cell ◽

Cote D'ivoire ◽

Côte D’Ivoire ◽

Stem Bark ◽

Traditional Healers ◽

Ethnobotanical Study ◽

Ethnobotanical Survey ◽

Cote D’Ivoire ◽

Plant Parts ◽

Côte D'ivoire

An ethnobotanical survey was conducted to record the various plant families, species, and plant parts used to manage sickle cell disease in the Indenié-Djouablin region eastern Côte d’Ivoire. Nine traditional healers aged 36 to 67 years old were selected in six different villages according to their reputation in knowledge of traditional medicine, their availability and their willingness to share information. A total of 26 species of plants belonging to 20 families were reported to have antisickling activity. Eleven (11) different medication recipes were composed from these 26 species of plants ((Afromonum melegueta (Roscoe) K. Schum., Xylopia aethiopica) mainly). The main plant parts used were stem bark (38%) followed by fruit (18%) and seeds (18%). The majority of the main plants recorded (84.61 %) were wild. From the recorded plants, 65.38 % were trees and 23.07 % shrubs. Most remedies (82%) were made up by decoction and were employed orally (54 %) or by enema (32 %). The potential anti-sickling activity of the plant species recorded during this study could be the effect of alkaloids, polyphenols, quinones and terpenoids compounds found during the phytochemical screening of the 26 plants species.

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