scholarly journals Microencapsulation of Extracts from Corn Hair: A Study on Drug Release and Anticancer Activity

2021 ◽  
Vol 7 (1) ◽  
pp. 12
Author(s):  
Prajakta Kulkarni ◽  
Madhumita Tawre ◽  
Mahesh Dere ◽  
Ayesha Khan
Keyword(s):  
Drug Release ◽  
Anticancer Activity

Folate-conjugated dually responsive micelles for targeted anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35658-35667 ◽  
Author(s):  
Lingling Zhao ◽  
Yajuan Zhang ◽  
Jia Shao ◽  
Hongze Liang ◽  
Haining Na ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Activity ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Dual Responsive

Folate-conjugated dual-responsive micelles were developed, sustained and sensitive drug release from the drug loaded micelles was observed. Folate-targeted micelles showed higher anticancer activity and enhanced cellar uptake than non-targeted ones.

Cathepsin B-Labile Dipeptide Linkers for Lysosomal Release of Doxorubicin from Internalizing Immunoconjugates:  Model Studies of Enzymatic Drug Release and Antigen-Specific In Vitro Anticancer Activity

2002 ◽  
Vol 13 (4) ◽  
pp. 855-869 ◽  
Author(s):  
Gene M. Dubowchik ◽  
Raymond A. Firestone ◽  
Linda Padilla ◽  
David Willner ◽  
Sandra J. Hofstead ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Activity ◽  
Cathepsin B ◽  
Model Studies

scholarly journals Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity

2019 ◽  
Vol 10 ◽  
pp. 2062-2072 ◽  
Author(s):  
Sebastian Pieper ◽  
Hannah Onafuye ◽  
Dennis Mulac ◽  
Jindrich Cinatl ◽  
Mark N Wass ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Release Kinetics ◽  
Neuroblastoma Cells ◽  
Plga Nanoparticles ◽  
Cellular Level ◽  
Drug Load ◽  
Anticancer Efficacy ◽  
Solvent Displacement

Background: Nanoparticles are under investigation as carrier systems for anticancer drugs. The expression of efflux transporters such as the ATP-binding cassette (ABC) transporter ABCB1 is an important resistance mechanism in therapy-refractory cancer cells. Drug encapsulation into nanoparticles has been shown to bypass efflux-mediated drug resistance, but there are also conflicting results. To investigate whether easy-to-prepare nanoparticles made of well-tolerated polymers may circumvent transporter-mediated drug efflux, we prepared poly(lactic-co-glycolic acid) (PLGA), polylactic acid (PLA), and PEGylated PLGA (PLGA-PEG) nanoparticles loaded with the ABCB1 substrate doxorubicin by solvent displacement and emulsion diffusion approaches and assessed their anticancer efficiency in neuroblastoma cells, including ABCB1-expressing cell lines, in comparison to doxorubicin solution. Results: The resulting nanoparticles covered a size range between 73 and 246 nm. PLGA-PEG nanoparticle preparation by solvent displacement led to the smallest nanoparticles. In PLGA nanoparticles, the drug load could be optimised using solvent displacement at pH 7 reaching 53 µg doxorubicin/mg nanoparticle. These PLGA nanoparticles displayed sustained doxorubicin release kinetics compared to the more burst-like kinetics of the other preparations. In neuroblastoma cells, doxorubicin-loaded PLGA-PEG nanoparticles (presumably due to their small size) and PLGA nanoparticles prepared by solvent displacement at pH 7 (presumably due to their high drug load and superior drug release kinetics) exerted the strongest anticancer effects. However, nanoparticle-encapsulated doxorubicin did not display increased efficacy in ABCB1-expressing cells relative to doxorubicin solution. Conclusion: Doxorubicin-loaded nanoparticles made by different methods from different materials displayed substantial discrepancies in their anticancer activity at the cellular level. Optimised preparation methods resulted in PLGA nanoparticles characterised by increased drug load, controlled drug release, and high anticancer efficacy. The design of drug-loaded nanoparticles with optimised anticancer activity at the cellular level is an important step in the development of improved nanoparticle preparations for anticancer therapy. Further research is required to understand under which circumstances nanoparticles can be used to overcome efflux-mediated resistance in cancer cells.

Recent developments in selenium-containing polymeric micelles: prospective stimuli, drug-release behaviors, and intrinsic anticancer activity

2021 ◽  
Author(s):  
Yihenew Simegniew Birhan ◽  
Hsieh-Chih Tsai
Keyword(s):  
Drug Release ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Polymeric Micelles ◽  
Recent Developments

Selenium-containing nanocarriers can respond to different stimuli to release payloads in the vicinity of cancer cells.

Sustained drug release and cancer treatment by an injectable and biodegradable cyanoacrylate-based local drug delivery system

2018 ◽  
Vol 6 (8) ◽  
pp. 1216-1225 ◽  
Author(s):  
Tao Zhang ◽  
Yongjia Tang ◽  
Wei Zhang ◽  
Shan Liu ◽  
Yumei Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
Drug Delivery System ◽  
Delivery System ◽  
Local Drug Delivery ◽  
Sustained Drug Release ◽  
System P ◽  
Local Drug Delivery System

A novel injectable and biodegradable cross-linked cyanoacrylate-based local drug delivery system with excellent anticancer activity.

scholarly journals Polymeric Mesoporous Silica Nanoparticles for Combination Drug Delivery In vitro

2020 ◽  
Vol 11 (4) ◽  
pp. 11905-11919
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Formulation ◽  
Combination Drug ◽  
Dual Drug

Despite the recent advances and development of conventional cancer therapy strategies, treatments often lack specificity, resulting in low therapeutic efficiency, cancer recurrence, and drug resistance. With the advent of nanotechnology, nanoparticle-based delivery systems have steadily gained interest. The key to using any drug delivery system is its’ relative cytotoxicity, pharmacokinetics, and downstream immunological effects that may arise upon repetitive exposure. Among the nanoparticle systems, mesoporous silica nanoparticles (MSNs) have received favorable attention as potential drug delivery platforms. This study aimed to synthesize and functionalized MSNs with chitosan and polyethyleneglycol for improved stability, efficient drug loading, and drug release. These polymerized MSNs were physicochemically and morphologically characterized and assessed for their dual-drug [doxorubicin (DOX)/5-fluoruracil (5-FU)] loading, drug release kinetics, and anticancer activity in vitro. MSNs ranged from 35-70 nm in size, with a high surface area (809.44 m²/g) and a large pore volume (1.74 cm²/g). The DOX/5-FU co-loading produced a potent dual-drug formulation with good pH-responsive release profiles, high percentage release, especially from PEGylated MSNs, and significant anticancer activity the breast adenocarcinoma (MCF-7) and cervical cancer (HeLa) cells. This combination therapy's favorable outcomes suggest an improved therapeutic strategy that warrants investigation in an in vivo model.

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