Site of Mitochondrial Reactive Oxygen Species Production in Skeletal Muscle of Chronic Obstructive Pulmonary Disease and Its Relationship with Exercise Oxidative Stress

2012 ◽  
Vol 47 (3) ◽  
pp. 358-362 ◽  
Author(s):  
Luis Puente-Maestu ◽  
Alberto Tejedor ◽  
Alberto Lázaro ◽  
Javier de Miguel ◽  
Luis ÁLvarez-Sala ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Chronic Obstructive Pulmonary Disease ◽  
Skeletal Muscle ◽  
Reactive Oxygen Species Production ◽  
Chronic Obstructive ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Obstructive Pulmonary Disease ◽  
Species Production

scholarly journals Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1537
Author(s):  
Akihiko Taniguchi ◽  
Mitsuru Tsuge ◽  
Nobuaki Miyahara ◽  
Hirokazu Tsukahara
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Reactive Oxygen ◽  
Chronic Obstructive ◽  
Oxygen Species ◽  
Antioxidative Defense ◽  
Obstructive Pulmonary Disease ◽  
Antioxidative Therapy

The respiratory system is continuously exposed to endogenous and exogenous oxidants. Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, leading to the destruction of lung parenchyma (emphysema) and declining pulmonary function. It is increasingly obvious that reactive oxygen species (ROS) and reactive nitrogen species (RNS) contribute to the progression and amplification of the inflammatory responses related to this disease. First, we described the association between cigarette smoking, the most representative exogenous oxidant, and COPD and then presented the multiple pathophysiological aspects of ROS and antioxidative defense systems in the development and progression of COPD. Second, the relationship between nitric oxide system (endothelial) dysfunction and oxidative stress has been discussed. Third, we have provided data on the use of these biomarkers in the pathogenetic mechanisms involved in COPD and its progression and presented an overview of oxidative stress biomarkers having clinical applications in respiratory medicine, including those in exhaled breath, as per recent observations. Finally, we explained the findings of recent clinical and experimental studies evaluating the efficacy of antioxidative interventions for COPD. Future breakthroughs in antioxidative therapy may provide a promising therapeutic strategy for the prevention and treatment of COPD.

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