The Role of Secreted Frizzled Related Protein-1 in Allergic Asthma

2021 ◽  
Author(s):  
Nooralam Rai ◽  
Emilio Arteaga-Solis ◽  
Monica Goldklang ◽  
Tina Zelonina ◽  
Jeanine D'Armiento
Keyword(s):  
Allergic Asthma ◽  
Related Protein

Investigating the role of BAFF in different mouse models of allergic asthma

Pneumologie ◽  
2014 ◽  
Vol 68 (06) ◽  
Author(s):  
A Lorenz ◽  
M Busse ◽  
K Dalüge ◽  
AK Behrendt ◽  
G Hansen ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Mouse Models

scholarly journals A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat

Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 140-148 ◽  
Author(s):  
M. L�pez ◽  
L. M. Seoane ◽  
S. Tovar ◽  
M. C. Garc�a ◽  
R. Nogueiras ◽  
...  
Keyword(s):  
Neuropeptide Y ◽  
Leptin Receptor ◽  
Related Protein ◽  
Receptor Isoforms ◽  
Agouti Related Protein

scholarly journals Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 4828-4840
Author(s):  
Guoliang Cui ◽  
Can Wang ◽  
Zhenyan Lin ◽  
Xiaoke Feng ◽  
Muxin Wei ◽  
...  
Keyword(s):  
Related Protein ◽  
Pan Cancer

Role of transient receptor potential cation channel subfamily V member 1 (TRPV1) on ozone-exacerbated allergic asthma in mice

2019 ◽  
Vol 247 ◽  
pp. 586-594 ◽  
Author(s):  
Jinquan Li ◽  
Yushan Chen ◽  
Qiao Yi Chen ◽  
Dan Liu ◽  
Lang Xu ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channel ◽  
Transient Receptor

scholarly journals Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 192
Author(s):  
Siska Van Belle ◽  
Sara El Ashkar ◽  
Kateřina Čermáková ◽  
Filip Matthijssens ◽  
Steven Goossens ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Survival ◽  
Cell Lines ◽  
Protein Interactions ◽  
Leukemic Cell ◽  
Related Protein ◽  
Histone Tails ◽  
Knockout Mouse Model ◽  
Leukemic Cell Lines

HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Derived Growth Factor p75 (LEDGF/p75), which is essential for MLL-rearranged (MLL-r) leukemia but dispensable for hematopoiesis. Sequel to these findings, we investigated the role of HRP-2 in hematopoiesis and MLL-r leukemia. Protein interactions were investigated by co-immunoprecipitation and validated using recombinant proteins in NMR. A systemic knockout mouse model was used to study normal hematopoiesis and MLL-ENL transformation upon the different HRP-2 genotypes. The role of HRP-2 in MLL-r and other leukemic, human cell lines was evaluated by lentiviral-mediated miRNA targeting HRP-2. We demonstrate that MLL and HRP-2 interact through a conserved interface, although this interaction proved less dependent on menin than the MLL-LEDGF/p75 interaction. The systemic HRP-2 knockout mice only revealed an increase in neutrophils in the peripheral blood, whereas the depletion of HRP-2 in leukemic cell lines and transformed primary murine cells resulted in reduced colony formation independently of MLL-rearrangements. In contrast, primary murine HRP-2 knockout cells were efficiently transformed by the MLL-ENL fusion, indicating that HRP-2, unlike LEDGF/p75, is dispensable for the transformation of MLL-ENL leukemogenesis but important for leukemic cell survival.

scholarly journals Dual role of the miR‐146 family in rhinovirus‐induced airway inflammation and allergic asthma exacerbation

2021 ◽  
Vol 11 (6) ◽  
Author(s):  
Anet Laanesoo ◽  
Egon Urgard ◽  
Kapilraj Periyasamy ◽  
Martti Laan ◽  
Yury A. Bochkov ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Allergic Asthma ◽  
Asthma Exacerbation ◽  
Dual Role

The role of female sex hormones in the development and severity of allergic and non-allergic asthma

2009 ◽  
Vol 39 (10) ◽  
pp. 1477-1481 ◽  
Author(s):  
M. van den Berge ◽  
H. I. Heijink ◽  
A. J. M. van Oosterhout ◽  
D. S. Postma
Keyword(s):  
Allergic Asthma ◽  
Sex Hormones ◽  
Female Sex ◽  
Female Sex Hormones

scholarly journals The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

2001 ◽  
Vol 1 (4) ◽  
pp. 515-525 ◽  
Author(s):  
Stephan Frank ◽  
Brigitte Gaume ◽  
Elke S. Bergmann-Leitner ◽  
Wolfgang W. Leitner ◽  
Everett G. Robert ◽  
...  
Keyword(s):  
Mitochondrial Fission ◽  
Related Protein
Sign in / Sign up

Export Citation Format

Share Document