Comparison of Image Quality of Multiple Magnetic Resonance Imaging Sequences in Multiple Myeloma

2021 ◽  
Vol 11 (2) ◽  
pp. 497-505
Author(s):  
Dandan Luo ◽  
Daming Qin ◽  
Hong Cheng ◽  
Meng Zhou ◽  
Daoming Zhu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Plasma Cells ◽  
Resonance Imaging ◽  
High Detection Rate ◽  
Clinical Images ◽  
Examination Methods ◽  
Magnetic Resonance Scanning

Multiple myeloma is a refractory malignant disease characterized by clonal hyper proliferation of plasma cells in the bone marrow microenvironment. In recent years, its incidence has gradually increased and it is younger. Magnetic resonance imaging is a medical imaging technology that has developed rapidly in recent years. Its application and promotion have greatly improved the level of medical services and scientific research. It has become one of the most important examination methods for myeloma. Magnetic resonance imaging has a high soft tissue resolution and has a high detection rate for multiple myeloma. However, there are few studies on the MM magnetic resonance scanning protocol, and the initial or follow-up examination methods have not been unified. Therefore, this paper subjectively and objectively evaluates the clinical images of MM patients with multiple sequences of magnetic resonance of different devices, and hopes to provide more advantageous examination methods for clinicians and patients. The experimental results show that magnetic resonance multisequence imaging can be ideal for clinical diagnosis and follow-up of MM patients.

scholarly journals The Prediction of Lymphohematopoietic Diseases by Incidentally-Detected Diffuse Signal Alterations of Bone Marrow on MRI

Acta Medica ◽  
2020 ◽  
Vol 51 (4) ◽  
pp. 48-53
Author(s):  
Rafiye Ciftciler ◽  
Kader Karlı Oguz ◽  
Yahya Buyukasik
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Myeloma ◽  
Bone Marrow ◽  
Magnetic Resonance ◽  
Imaging Techniques ◽  
Resonance Imaging ◽  
Bone Marrow Signal ◽  
Time Of Presentation ◽  
Marrow Signal

Objective: Advanced imaging techniques are increasingly used in the diagnostic workup of patients. The clinical significance of incidentally-detected signal alterations of the bone marrow on magnetic resonance imaging has not been widely studied. The purpose of this study was to determine whether bone marrow signal changing on magnetic resonance imaging could predict a hematologic disease. Materials and Methods: Thirty patients who were referred to Hematology department due to bone marrow signal alteration on magnetic resonance imaging between the years of 2011 and 2018 were evaluated. Results: There were 8 males and 22 females with a median age of 53 (range, 31–86) years at the time of presentation to the Hematology clinic. The magnetic resonance imaging studies had been taken because the patients had complaints of pain in extremities or lumbago (80%). The patients had been followed for median 4.5 months (0-71.7). Six (20%) cases had a bone marrow biopsy at presentation and a diagnosis was established in 5 (16.6%) of them (1 patient was diagnosed acute myeloid leukemia, 4 patients were diagnosed multiple myeloma). Marrow biopsy was done in 11 of the cases during follow-up median 3.8 months (1.3-11.5) after presentation. A diagnosis was made in 9 cases (5 patients were diagnosed multiple myeloma, 2 patients were diagnosed follicular lymphoma, 1 patient was diagnosed waldenstrom macroglobulinemia). Thirteen cases never had a biopsy. These cases had been followed for 1.3 months (0-71.7). None of them showed clinical abnormalities related to a lymphohematopoietic disorder and/or diagnosed with such a disorder. Only 1 patient was diagnosed with osteomalacia at follow-up. Conclusion: Incidentally-detected signal alterations of the bone marrow on magnetic resonance imaging should trigger investigations for a marrow problem. Most of the diagnosis patients were multiple myeloma. Extremity pain and findings like anemia may be associated with lymphohematological malignancies.

scholarly journals Prognostic Value of Diffusion-Weighted Magnetic Resonance Imaging in Newly Diagnosed Multiple Myeloma Patients Treated with up-Front Autologous Transplantation

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3146-3146
Author(s):  
Elena Fernández-Poveda ◽  
Valentin Cabañas ◽  
Maria José Moreno ◽  
Miguel Blanquer Blanquer ◽  
José M Moraleda
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Induction Treatment ◽  
Focal Lesion ◽  
Resonance Imaging ◽  
Diffusion Weighted ◽  
Pet Ct ◽  
Weighted Magnetic Resonance Imaging

Background and aims: Bone disease extension in symptomatic multiple myeloma (MM) has prognostic implications. However, methods better than the traditional ones are necessary to establish the diagnosis according to the updated International Myeloma Working Group criteria (IMWG). Magnetic resonance imaging (MRI) is a novel technique to detect bone lesions at diagnosis. The IMWG has incorporated it to the diagnostic work-up. However, due to MRI false-positive results in non-viable lesions, PET-TC is preferred during follow-up to assess prognosis. Diffusion-weighted magnetic resonance imaging (DW-MRI) uses the diffusion of water in the bone marrow, which is greatly influenced by cellularity and tumor burden. DW-MRI has been explored for the assessment of minimal residual disease (MRD) after autologous stem cell transplantation (ASCT) in a recently published study, showing better progression free survival (PFS) in patients with negative DW-MRI. Our aim is to compare the PFS in patients with MM with negative and positive DW-MRI at 3 months of ASCT and to assess the differences with PET-CT. Methods: MRI and PET/CT were performed in patients diagnosed with symptomatic MM at 3 months after ASCT. All patients received a Bortezomib based three drugs combination as induction treatment. None received maintenance. Any ≥5 mm focal lesion seen on PET-CT with standardized uptake value (SUVmax)>2.5 for bone tissue or >3.5 for soft tissues was considered positive. Any ≥5 mm focal lesion seen on DW-MRI that restricted the diffusion, as well as the presence of extramedullary disease, was considered positive. Statistical analysis was performed using the Kaplan Meier test and Fisher's exact test. Results: The baseline characteristics of the 17 patients included are shown in Table 1. The median PFS in the positive DW-MRI group was 28 months, whereas the median PFS in the negative DW-MRI group was not reached (p=0.029) (image 1). Both tests were coincidently positive in 3 patients (17%) and negative in 7 patients (41%). There was no coincidence in the remaining 7 (41%) patients, 5 (29%) being DW-MRI positive and 2 (11%) being PET-TAC positive. The difference was statistically non-significant. Conclusions: In our population, patients with negative DW-MRI after ASCT have a significantly higher PFS. These data are favorable to the use of DW-MRI in the follow-up of MM. Disclosures No relevant conflicts of interest to declare.

Multisession CyberKnife Radiosurgery for Intramedullary Spinal Cord Arteriovenous Malformations

Neurosurgery ◽  
2006 ◽  
Vol 58 (6) ◽  
pp. 1081-1089 ◽  
Author(s):  
John Sinclair ◽  
Steven D. Chang ◽  
Iris C. Gibbs ◽  
John R. Adler
Keyword(s):  
Magnetic Resonance Imaging ◽  
Spinal Cord ◽  
Magnetic Resonance ◽  
Arteriovenous Malformations ◽  
Conus Medullaris ◽  
Spinal Angiography ◽  
Resonance Imaging ◽  
Intramedullary Spinal Cord ◽  
Cyberknife Radiosurgery

Abstract OBJECTIVE: Intramedullary spinal cord arteriovenous malformations (AVMs) have an unfavorable natural history that characteristically involves myelopathy secondary to progressive ischemia and/or recurrent hemorrhage. Although some lesions can be managed successfully with embolization and surgery, AVM size, location, and angioarchitecture precludes treatment in many circumstances. Given the poor outlook for such patients, and building on the successful experience with radiosurgical ablation of cerebral AVMs, our group at Stanford University has used CyberKnife (Accuray, Inc., Sunnyvale, CA) stereotactic radiosurgery (SRS) to treat selected spinal cord AVMs since 1997. In this article, we retrospectively analyze our preliminary experience with this technique. METHODS: Fifteen patients with intramedullary spinal cord AVMs (nine cervical, three thoracic, and three conus medullaris) were treated by image-guided SRS between 1997 and 2005. SRS was delivered in two to five sessions with an average marginal dose of 20.5 Gy. The biologically effective dose used in individual patients was escalated gradually over the course of this study. Clinical and magnetic resonance imaging follow-up were carried out annually, and spinal angiography was repeated at 3 years. RESULTS: After a mean follow-up period of 27.9 months (range, 3–59 mo), six of the seven patients who were more than 3 years from SRS had significant reductions in AVM volumes on interim magnetic resonance imaging examinations. In four of the five patients who underwent postoperative spinal angiography, persistent AVM was confirmed, albeit reduced in size. One patient demonstrated complete angiographic obliteration of a conus medullaris AVM 26 months after radiosurgery. There was no evidence of further hemorrhage after CyberKnife treatment or neurological deterioration attributable to SRS. CONCLUSION: This description of CyberKnife radiosurgical ablation demonstrates its feasibility and apparent safety for selected intramedullary spinal cord AVMs. Additional experience is necessary to ascertain the optimal radiosurgical dose and ultimate efficacy of this technique.

Magnetic Resonance Imaging T2* Mapping of the Talar Dome and Subtalar Joint Cartilage 3 Years After Anterior Talofibular Ligament Repair or Reconstruction in Chronic Lateral Ankle Instability

2021 ◽  
Vol 49 (3) ◽  
pp. 737-746
Author(s):  
Yiwen Hu ◽  
Yuyang Zhang ◽  
Qianru Li ◽  
Yuxue Xie ◽  
Rong Lu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Ankle Instability ◽  
Anterior Talofibular Ligament ◽  
Resonance Imaging ◽  
Talar Dome ◽  
Lateral Ankle ◽  
Chronic Lateral Ankle Instability ◽  
Lateral Ankle Instability

Background: Cartilage degeneration is a common issue in patients with chronic lateral ankle instability. However, there are limited studies regarding the effectiveness of lateral ligament surgery on preventing talar and subtalar joint cartilage from further degenerative changes. Purpose: To longitudinally evaluate talar and subtalar cartilage compositional changes using magnetic resonance imaging T2* mapping in anatomic anterior talofibular ligament (ATFL)–repaired and ATFL-reconstructed ankles and to compare them with measures in asymptomatic controls. Study Design: Cohort study; Level of evidence, 3. Methods: Between January 2015 and December 2016, patients with chronic lateral ankle instability who underwent anatomic ATFL repair (n = 19) and reconstruction (n = 20) were prospectively recruited. Patients underwent 3.0-T magnetic resonance imaging at baseline and 3-year follow-up. As asymptomatic controls, 21 healthy volunteers were recruited and underwent imaging at baseline. Talar dome cartilage was divided into (1) medial anterior, central, and posterior and (2) lateral anterior, central, and posterior. Posterior subtalar cartilage was divided into (1) central talus and calcaneus and (2) lateral talus and calcaneus. Ankle function was assessed using the American Orthopaedic Foot & Ankle Society scores. Results: There were significant increases in T2* values in medial and lateral posterior and central talus cartilage from baseline to 3-year follow-up in patients who underwent repair. T2* values were significantly higher in ATFL-repaired ankles at follow-up for all cartilage regions of interest, except medial and lateral anterior and lateral central, compared with those in healthy controls. From baseline to 3-year follow-up, ATFL-reconstructed ankles had a significant increase in T2* values in lateral central and posterior cartilage. T2* values in ATFL-reconstructed ankles at follow-up were elevated in all cartilage regions of interest, except medial and lateral anterior, compared with those in healthy controls. ATFL-repaired ankles showed a greater decrease of T2* values from baseline to follow-up in lateral calcaneus cartilage than did ATFL-reconstructed ankles ( P = .031). No significant differences in American Orthopaedic Foot & Ankle Society score were found between repair and reconstruction procedures (mean ± SD, 19.11 ± 7.45 vs 16.85 ± 6.24; P = .311). Conclusion: Neither anatomic ATFL repair nor reconstruction could prevent the progression of talar dome and posterior subtalar cartilage degeneration; however, ankle function and activity levels were not affected over a short period. Patients who underwent ATFL repair exhibited lower T2* values in the lateral calcaneus cartilage than did those who underwent reconstruction.

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