Tumbling Mill Process as a Tool to Develop Core–Shell Nanoparticles for Biomedical Applications. Preliminary Analysis and Testing

2021 ◽  
Vol 21 (5) ◽  
pp. 2864-2871
Author(s):  
Mariangela Bellusci ◽  
Alberto Boschetto ◽  
Luana Bottini ◽  
Aurelio La Barbera ◽  
Andrea Masi ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Low Cost ◽  
Core Shell ◽  
Multifunctional Composites ◽  
Shell Nanoparticles ◽  
Dry Process ◽  
Catch Up ◽  
Core Shell Nanoparticles ◽  
Tumbling Mill ◽  
Proper Analysis

A new mechanical dry process able to develop nanoparticles coated with polymeric material is proposed. An opportunely developed pilot ball milling apparatus permitted to catch-up significant process parameters that are here reported. A proper analysis of the obtained parameters permitted to individuate optimized milling conditions and to prepare a magnetite/albumin core/shell nanocomposite, material with a potential wide spread of applications in biomedical fields. The obtained powder consists in particles having a diameter of about 45 nm and exhibits a high morphological homogeneity. The proposed method is facile, low cost, solvent free and is applicable to the development of a broad range of multifunctional composites for biomedical applications.

scholarly journals Bimetallic Core–Shell Nanoparticles of Gold and Silver via Bioinspired Polydopamine Layer as Surface-Enhanced Raman Spectroscopy (SERS) Platform

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 688 ◽  
Author(s):  
Asli Yilmaz ◽  
Mehmet Yilmaz
Keyword(s):  
Raman Spectroscopy ◽  
Low Cost ◽  
Silver Ions ◽  
Surface Enhanced Raman Spectroscopy ◽  
Core Shell ◽  
Silver Deposition ◽  
Shell Nanoparticles ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Core Shell Nanoparticles

Despite numerous attempts to fabricate the core–shell nanoparticles, novel, simple, and low-cost approaches are still required to produce these efficient nanosystems. In this study, we propose the synthesis of bimetallic core–shell nanoparticles of gold (AuNP) and silver (AgNP) nanostructures via a bioinspired polydopamine (PDOP) layer and their employment as a surface-enhanced Raman spectroscopy (SERS) platform. Herein, the PDOP layer was used as an interface between nanostructures as well as stabilizing and reducing agents for the deposition of silver ions onto the AuNPs. UV-vis absorption spectra and electron microscope images confirmed the deposition of the silver ions and the formation of core–shell nanoparticles. SERS activity tests indicated that both the PDOP thickness and silver deposition time are the dominant parameters that determine the SERS performances of the proposed core–shell system. In comparison to bare AuNPs, more than three times higher SERS signal intensity was obtained with an enhancement factor of 3.5 × 105.

Radiosynthesis of Gold/Albumin Core/shell Nanoparticles for Biomedical Applications

MRS Advances ◽  
2017 ◽  
Vol 2 (49) ◽  
pp. 2675-2681 ◽  
Author(s):  
Constanza Y. Flores ◽  
Estefania Achilli ◽  
Mariano Grasselli
Keyword(s):  
Gold Nanoparticles ◽  
Biomedical Applications ◽  
Irradiation Dose ◽  
Ftir Spectrum ◽  
Core Shell ◽  
Peak Shape ◽  
Shell Nanoparticles ◽  
Plasmon Peak ◽  
Radiation Induced ◽  
Core Shell Nanoparticles

ABSTRACTGold/albumin core/shell nanoparticles (Au/AlbNPs) was prepared by a novel aggregation/crosslinking technique and characterized by several spectroscopic and microscopy methods. Albumin, in presence of gold nanoparticles (AuNPs), is aggregated by the addition of ethanol and further stabilized by radiation-induced crosslinking using a 60Co source. Nanoconstructs are characterized to determine size, morphology and optical characteristics. The Au/AlbNPs were prepared in different ethanol and albumins concentrations. Results showed that it is possible to obtain Au/AlbNPs using ethanol 30 %v/v, albumin in different concentrations and an irradiation dose of 10 kGy. Au/AlbNP plasmon peak shifted to 530 nm, keeping the typical plasmon peak shape. The size of Au/AlbNPs is approximately double respect to the naked AuNPs and they show core/shell type morphology. The main amide peaks of albumin in FTIR spectrum can be found in the spectrum of nanoconstructs.

Facile synthesis of multifunctional La1−xSrxMnO3@Au core–shell nanoparticles for biomedical applications

RSC Advances ◽  
2015 ◽  
Vol 5 (116) ◽  
pp. 95454-95462 ◽  
Author(s):  
Xiao Liu ◽  
Hong-Ling Liu ◽  
Ning Fang ◽  
Xue-Mei Li ◽  
Wei-Hua Guo ◽  
...  
Keyword(s):  
Optical Properties ◽  
Biomedical Applications ◽  
High Performance ◽  
Core Shell ◽  
Facile Synthesis ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Multifunctional high-performance La1−xSrxMnO3@Au core–shell nanoparticles were synthesized by nanoemulsion with polymers, showing sharp Curie transition, excellent amphiphilic dispersibility and optical properties as well as biocompatibility.

The Preparation and Characteristic of Superparamagnetic Core/Shell Nanoparticles

2013 ◽  
Vol 274 ◽  
pp. 432-435
Author(s):  
Hong Xia Shen ◽  
Zheng Zhi Yin ◽  
Qiong Cheng
Keyword(s):  
Biomedical Applications ◽  
Superparamagnetic Nanoparticles ◽  
Bioactive Molecules ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
X Ray ◽  
Transmission Electron ◽  
Vibration Sample Magnetometer ◽  
Diffraction Patterns ◽  
Core Shell Nanoparticles

Superparamagnetic core/shell nanoparticles have been prepared successfully by the reduction of Au3+ onto the surface of superparamagnetic nanoparticles. The core/shell nanoparticles were characterized by Transmission electron microscopy (TEM), X-ray powder diffraction patterns (XRD), UV–vis spectrophotometer, Vibration Sample Magnetometer(VSM) and micro-confocal Raman system. The results revealed that the prepared core/shell nanoparticles were covered by Au shell. These superparamagnetic nanoparticles can be highly sensitively detected and afford new opportunities for biomedical applications through chemical bonding of bioactive molecules with the Au shell of nanoparticles.

Synthesis and Stability of Highly Crystalline and Stable Iron/Iron Oxide Core/Shell Nanoparticles for Biomedical Applications

ChemPlusChem ◽  
2012 ◽  
Vol 77 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Soshan Cheong ◽  
Peter Ferguson ◽  
Ian F. Hermans ◽  
Guy N. L. Jameson ◽  
Sujay Prabakar ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Biomedical Applications ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Iron Iron ◽  
Iron Oxide Core ◽  
Core Shell Nanoparticles

Investigation of magnetoelectric properties and biocompatibility of CoFe2O4-BaTiO3 core-shell nanoparticles for biomedical applications

2017 ◽  
Vol 122 (16) ◽  
pp. 164102 ◽  
Author(s):  
Badari Narayana Rao ◽  
P. Kaviraj ◽  
S. R. Vaibavi ◽  
Amit Kumar ◽  
Saumendra Kumar Bajpai ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Magnetoelectric Properties ◽  
Core Shell Nanoparticles

scholarly journals Controllable Engineering and Functionalizing Nanoparticles with Specific Targeting Capability

2021 ◽  
Author(s):  
Zhanchen Guo ◽  
Rongrong Xing ◽  
Zhen Liu
Keyword(s):  
Breast Cancer ◽  
Biomedical Applications ◽  
High Specificity ◽  
Superparamagnetic Nanoparticles ◽  
Breast Cancer Cell Lines ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Specific Targeting ◽  
Dual Functional ◽  
Core Shell Nanoparticles

Abstract Due to unique properties, nanoparticles been widely used in important biomedical applications such as imaging, drug delivery and disease therapy. Targeting toward specific proteins is essential for the effective utilization of nanoparticles. However, current targeting strategies mainly rely on surface modification with bio-ligands, which often not only fail to provide desired properties but also remain challenging. Here we report an unprecedented approach, called reverse microemulsion-confined epitope-oriented surface imprinting and cladding (ROSIC), for facile, versatile and controllable engineering coreless and core/shell nanoparticles with tunable monodispersed size as well as specific targeting capability towards proteins and peptides. Via engineering coreless imprinted and cladded silica nanoparticles, the effectiveness and superiority over conventional imprinting of the proposed approach was first verified. The prepared nanoparticles exhibited both high specificity and high affinity. Using quantum dots (QDs), superparamagnetic nanoparticles, silver nanoparticles and upconverting nanoparticles as a representative set of core substrates, a variety of dual-functional single-core/shell nanoparticles were then successfully prepared. Finally, selective fluorescence imaging of triple negative breast cancer cells over other breast cancer cell lines using QD-cored nanoparticles was achieved, which well demonstrated the potential of the prepared core/shell nanoparticles in biomedical applications. Thus, this approach opened a new avenue to engineering and functionalization of advanced nanoparticles with targeting capability, holding great prospects in biomedical applications.

scholarly journals Preparation and Characterization of Magnetite – Silica Core – Shell Nanoparticles

2021 ◽  
Vol 15 ◽  
pp. 1457-1463
Author(s):  
S. N. Vakhneev ◽  
Minggong Sha
Keyword(s):  
Magnetite Nanoparticles ◽  
Biomedical Applications ◽  
Core Shell ◽  
Amino Groups ◽  
Absorption Bands ◽  
Shell Nanoparticles ◽  
Oh Groups ◽  
Silica Core ◽  
Core Shell Nanoparticles

In this study, two types of ligands were introduced onto the surface of magnetite nanoparticles by hydrolysis and condensation of organosilicon reagents: organosilane-tetraethoxysilane (TEOS) and aminoorganosilane - aminopropyltriethoxysilane (APTES). It is shown that coatings based on SiO2 solve a double problem: first, they prevent the aggregation of nanoparticles and the oxidation of magnetite; secondly, they allow the surface to be modified with various specific ligands for biomedical applications due to terminal groups. It was shown, that after the modification of TEOS and APTES (in argon and in air), the Fe3O4 content decreases to 66, 42, and 36%, respectively. The formation of a silicon framework on the magnetite surface due to Fe-O-Si and Si-O-Si bonds was determined by IR spectroscopy. The identification of surface amino groups is complicated due to the superposition of absorption bands of NH2- and OH-groups. This opens new prospective for creation of tailored nanocomposites containing magnetite nanoparticles. These materials can be further used as sorbents for various applications.

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