Screening of Electrolyte Complexes Formed Between Dextran Sulfate and Amine Structures of Small-Molecule Drugs

2021 ◽  
Vol 21 (7) ◽  
pp. 3679-3682
Author(s):  
Seung Ah Choi ◽  
Eun Ji Park ◽  
Young Hun Kim ◽  
Jun-Pil Jee ◽  
Sung-Tae Kim ◽  
...  
Keyword(s):  
Small Molecule ◽  
Electrostatic Interactions ◽  
Dextran Sulfate ◽  
Drug Carrier ◽  
Acetate Buffer Solution ◽  
Carrier System ◽  
Buffer Solution ◽  
Small Molecule Drugs ◽  
Colloidal Drug Carrier ◽  
Drug Carrier System

Formation of an electrolyte complex using the electrostatic interactions between a polyanionic polymer and a cationic drug is a simple and efficient method of preparing a colloidal drug carrier system. Dextran sulfate, with a negatively charged sulfate group, was reacted in an acetate buffer solution of pH 3 with positively charged 1° amine, 2° amine, 3° amine, piperazine, and piperidine structures from 24 small-molecule drugs. The electrolyte complex was formed from 15 drugs, 63% of those tested. The tendency to form the electrolyte complex was in the order of piperazine and piperidine >3° amine >>2° amine. The drugs with the 1° amine structure failed to form an electrolyte complex. The mean particle sizes were in the range of 50-740 nm, and most of them showed a submicron colloidal dispersion of <400 nm. Regarding drug encapsulation efficiency (%), 11 drugs with piperazine, piperidine, and 3° amine structures showed 60–98% efficiency, which was fairly high. The results suggest that directly forming the electrolyte complex with dextran sulfate yields promising structural attributes as a submicron colloidal drug carrier system.

Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)

2021 ◽  
Vol 9 (9) ◽  
pp. 2233-2239
Author(s):  
Adrià Botet-Carreras ◽  
Cristina Tamames-Tabar ◽  
Fabrice Salles ◽  
Sara Rojas ◽  
Edurne Imbuluzqueta ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Aqueous Solubility ◽  
Carrier System ◽  
System P ◽  
Metal Organic ◽  
Drug Carrier System ◽  
Organic Framework

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.

Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2008 ◽  
Vol 1140 ◽  
Author(s):  
Wolfgang Tremel ◽  
Mohammed Ibrahim Shukoor ◽  
Filipe Natalio ◽  
Muhammad Nawaz Tahir ◽  
Matthias Wiens ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Drug Carrier ◽  
Optical Detection ◽  
Cpg Odn ◽  
Carrier System ◽  
Functionalized Magnetic Nanoparticles ◽  
Selective Targeting ◽  
Target Molecules ◽  
Drug Carrier System

ABSTRACTMnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.x

Studies on a bioerodible drug carrier system based on polyphosphazene Part I. Synthesis

1986 ◽  
Vol 3 (1-4) ◽  
pp. 143-154 ◽  
Author(s):  
C.W.J. Grolleman ◽  
A.C. de Visser ◽  
J.G.C. Wolke ◽  
H. van der Goot ◽  
H. Timmerman
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Drug Carrier System

Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes

Biomaterials ◽  
2005 ◽  
Vol 26 (15) ◽  
pp. 2723-2732 ◽  
Author(s):  
Sabine Balthasar ◽  
Kerstin Michaelis ◽  
Norbert Dinauer ◽  
Hagen von Briesen ◽  
Jörg Kreuter ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Gelatin Nanoparticles ◽  
Drug Carrier System

The Current Research Status of PLGA as Drug and Gene Carrier

2016 ◽  
Vol 42 ◽  
pp. 80-91 ◽  
Author(s):  
Ji Wei Wu ◽  
Guo Hua Li ◽  
Shu Qin Cui ◽  
Jing He Wang ◽  
Xiang Ling Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
Surface Modification ◽  
Controlled Release ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Synthetic Methods ◽  
Carrier System ◽  
Carrier Materials ◽  
Controlled Release System ◽  
Drug Carrier System

PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.

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