Functionalized Magnetic Nanoparticles for Selective Targeting of Cells

2008 ◽  
Vol 1140 ◽  
Author(s):  
Wolfgang Tremel ◽  
Mohammed Ibrahim Shukoor ◽  
Filipe Natalio ◽  
Muhammad Nawaz Tahir ◽  
Matthias Wiens ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Drug Carrier ◽  
Optical Detection ◽  
Cpg Odn ◽  
Carrier System ◽  
Functionalized Magnetic Nanoparticles ◽  
Selective Targeting ◽  
Target Molecules ◽  
Drug Carrier System

ABSTRACTMnO nanoparticles were conjugated to single stranded DNA (ssDNA), Cytosin-phosphatidyl-Guanosin oligonucleotide (CpG ODN) to detect and activate Toll-like (TLR9) receptors in cells and to follow nanoparticle cellular trafficking by different means of imaging while at the same time serving as a drug carrier system. By virtue of their magnetic properties these nanoparticles may serve as vehicles for the transport of target molecules into cells, while the fluorescent target ligand allows optical detection simultaneously.x

Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)

2021 ◽  
Vol 9 (9) ◽  
pp. 2233-2239
Author(s):  
Adrià Botet-Carreras ◽  
Cristina Tamames-Tabar ◽  
Fabrice Salles ◽  
Sara Rojas ◽  
Edurne Imbuluzqueta ◽  
...  
Keyword(s):  
Oral Bioavailability ◽  
Metal Organic Framework ◽  
Drug Carrier ◽  
Aqueous Solubility ◽  
Carrier System ◽  
System P ◽  
Metal Organic ◽  
Drug Carrier System ◽  
Organic Framework

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.

Hydroxypropyl methylcellulose/graphene oxide composite as drug carrier system for5‐Fluorouracil

2021 ◽  
pp. 2100183
Author(s):  
Mohamed S. Hasanin ◽  
Mohamed El‐Sakhawy ◽  
Hanaa. Y. Ahmed ◽  
Samir Kamel
Keyword(s):  
Graphene Oxide ◽  
Drug Carrier ◽  
Hydroxypropyl Methylcellulose ◽  
Carrier System ◽  
Oxide Composite ◽  
Drug Carrier System

The intracellular release of methotrexate from a synthetic drug carrier system targeted to fc receptor-bearing cells

1989 ◽  
Vol 10 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Shen Wei-Chiang ◽  
Du Xiantang ◽  
Edward P. Feener ◽  
Hugues J.-P. Ryser
Keyword(s):  
Drug Carrier ◽  
Fc Receptor ◽  
Carrier System ◽  
Intracellular Release ◽  
Synthetic Drug ◽  
Drug Carrier System

Studies on a bioerodible drug carrier system based on polyphosphazene Part I. Synthesis

1986 ◽  
Vol 3 (1-4) ◽  
pp. 143-154 ◽  
Author(s):  
C.W.J. Grolleman ◽  
A.C. de Visser ◽  
J.G.C. Wolke ◽  
H. van der Goot ◽  
H. Timmerman
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Drug Carrier System

Preparation and characterisation of antibody modified gelatin nanoparticles as drug carrier system for uptake in lymphocytes

Biomaterials ◽  
2005 ◽  
Vol 26 (15) ◽  
pp. 2723-2732 ◽  
Author(s):  
Sabine Balthasar ◽  
Kerstin Michaelis ◽  
Norbert Dinauer ◽  
Hagen von Briesen ◽  
Jörg Kreuter ◽  
...  
Keyword(s):  
Drug Carrier ◽  
Carrier System ◽  
Gelatin Nanoparticles ◽  
Drug Carrier System

The Current Research Status of PLGA as Drug and Gene Carrier

2016 ◽  
Vol 42 ◽  
pp. 80-91 ◽  
Author(s):  
Ji Wei Wu ◽  
Guo Hua Li ◽  
Shu Qin Cui ◽  
Jing He Wang ◽  
Xiang Ling Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
Surface Modification ◽  
Controlled Release ◽  
Glycolic Acid ◽  
Drug Carrier ◽  
Synthetic Methods ◽  
Carrier System ◽  
Carrier Materials ◽  
Controlled Release System ◽  
Drug Carrier System

PLGA, poly (lactic-co-glycolic-acid), is a kind of biodegradable functional macromolecular organic compounds. PLGA, certified by the Food and Drug Administration (FDA), possesses desirable features of biocompatibility, nontoxicity and no immune response, and is being widely applied to human clinical medical research. Because of its biodegradability, simple synthetic methods, controllability of degrading rate and desirable plasticity, PLGA was applied in large quantity into the carrier materials which is to control the release in recent years, gradually propelling PLGA microsphere controlled release system to be the most ideal drug-carrier system at present. As the carrier of drug and genes, PLGA is mainly researched on its features as the carrier, synthetic methods, different surface modification methods, and the applications on different drugs, genetic treatments and genetic vaccines.

scholarly journals Preparation of chitosan-Epigallocatechin-3-O-gallate nanoparticles and their inhibitory effect on the growth of breast cancer cells

2018 ◽  
Vol 11 (04) ◽  
pp. 1850018 ◽  
Author(s):  
Yingyi Liu ◽  
Siyi Hu ◽  
Yueshu Feng ◽  
Peng Zou ◽  
Yue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Drug Carrier ◽  
Scratch Test ◽  
Inhibitory Effect ◽  
Inhibition Rate ◽  
Carrier System ◽  
A Cell ◽  
Drug Carrier System

In this paper, we prepared the nanoparticle drug carrier system between nanoparticles — chitosan and Epigallocatechin-3-O-gallate (EGCG) for breast cancer cell inhibiting application. For this drug carrier system, chitosan acts as a carrier and EGCG as a drug. Which were systematically characterized and thoroughly evaluated in terms of their inhibition rate and biocompatibility. We also did a cell scratch test and the result indicated that the chitosan-EGCG nanoparticles have inhibitory effect on the growth of breast cancer cells. The inhibition rate could reach up to 21.91%. This work revealed that the modification of nanoparticles paved a way for specific biomedical applications.

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