Gold Nanoparticle-Optimized Computed Tomography Imaging Combined with Transcranial Magnetic Stimulation on Rehabilitation Training of Children with Cerebral Palsy

Traditional computed tomography (CT) contrast agents, such as iodine-containing small molecules (omnipaque), have limitations in some applications. The development of nanotechnology has made it possible to develop CT contrast agents based on this technology. In this study, a large number of surface functional groups of the fifth-generation polyamide-amine dendrimer (P5-NH2) were applied to functionally modify polyethylene glycol (PEG), targeting molecules, or drugs, which were used as the carrier of CT contrast agents. With the help of sodium borohydride (NaBH4), there was a rapid reduction. The fluorescein thiocyanate (FT) and PEG modified with lactobionic acid (PEG-LA) weres connected before gold coating to obtain gold nanoparticles coated with targeted dendrimer (Au(P5-LA)DENPs). In the experiment, the gold nanoparticles were characterized, and the liver cancer nude mouse model was established, so as to analyze the CT imaging performance of the material. Besides, the above was applied in the motor function of children with cerebral palsy, and the improvement effect of CT imaging combined with transcranial magnetic stimulation based on the preparation of nanomaterials on the movement function of children was analyzed and demonstrated with the help of graph theory. The results showed that the average particle size of gold nanoparticles was 1.88 nm. Within the range of 5 °C–50 °C and pH = 4–7, the physical properties of the aqueous solution of this material were stable. What’s more, the cell activity still exceeded 80% when the material concentration reached 2000 nm. The nude mouse model of liver cancer indicated that the CT imaging based on this material enhanced the image contrast effect of the tumor part, and the material had no obvious toxic and side effects. CT imaging based on the preparation of nanomaterials can promote transcranial magnetic stimulation to accelerate the efficiency of brain movement, accelerate the global and local information exchange and integration speed of brain network, thereby improving the movement function of children.

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Facile Fabrication of BiF3: Ln (Ln = Gd, Yb, Er)@PVP Nanoparticles for High-Efficiency Computed Tomography Imaging

Nanoscale Research Letters ◽

10.1186/s11671-021-03591-2 ◽

2021 ◽

Vol 16 (1) ◽

Author(s):

Jun Xie ◽

Zonglang Zhou ◽

Sihan Ma ◽

Xian Luo ◽

Jiajing Liu ◽

...

Keyword(s):

Computed Tomography ◽

Oral Administration ◽

Contrast Agent ◽

Contrast Agents ◽

Ct Imaging ◽

Average Particle ◽

Gi Tract ◽

X Ray ◽

Ct Value ◽

Ct Contrast

AbstractX-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number (Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm2 kg−1 at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF3: Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF3: Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF3: Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF3: Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF3: Ln@PVP NPs. Finally, the BiF3: Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF3: Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging.

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Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Biomaterials ◽

10.1016/j.biomaterials.2016.06.015 ◽

2016 ◽

Vol 102 ◽

pp. 87-97 ◽

Cited By ~ 102

Author(s):

Rabee Cheheltani ◽

Rami M. Ezzibdeh ◽

Peter Chhour ◽

Kumidini Pulaparthi ◽

Johoon Kim ◽

...

Keyword(s):

Computed Tomography ◽

Gold Nanoparticles ◽

Contrast Agents ◽

Photoacoustic Imaging

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Evaluation of image quality and radiation dose using gold nanoparticles and other clinical contrast agents in dual-energy Computed Tomography (CT): CT abdomen phantom

Journal of Physics Conference Series ◽

10.1088/1742-6596/851/1/012008 ◽

2017 ◽

Vol 851 ◽

pp. 012008 ◽

Cited By ~ 1

Author(s):

J Zukhi ◽

D Yusob ◽

A A Tajuddin ◽

L Vuanghao ◽

R Zainon

Keyword(s):

Computed Tomography ◽

Gold Nanoparticles ◽

Image Quality ◽

Radiation Dose ◽

Contrast Agents ◽

Dual Energy ◽

Dual Energy Computed Tomography

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X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer

Nanotechnology ◽

10.1088/0957-4484/21/24/245104 ◽

2010 ◽

Vol 21 (24) ◽

pp. 245104 ◽

Cited By ~ 98

Author(s):

Chie Kojima ◽

Yasuhito Umeda ◽

Mikako Ogawa ◽

Atsushi Harada ◽

Yasuhiro Magata ◽

...

Keyword(s):

Computed Tomography ◽

Gold Nanoparticles ◽

Contrast Agents ◽

Seeded Growth ◽

X Ray ◽

X Ray Computed

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Application of CT Contrast Agents in PET-CT Imaging

Clinical PET-CT in Radiology ◽

10.1007/978-0-387-48902-5_9 ◽

2010 ◽

pp. 91-101

Author(s):

Gerald Antoch ◽

Patrick Veit ◽

Andreas Bockisch ◽

Hilmar Kuehl

Keyword(s):

Contrast Agents ◽

Ct Imaging ◽

Pet Ct ◽

Ct Contrast

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CMR 2007: 8.03: Gold nanoparticles as contrast agents for MRI and X-ray computed tomography imaging

Contrast Media & Molecular Imaging ◽

10.1002/cmmi.195 ◽

2007 ◽

Vol 2 (6) ◽

pp. 292-293

Author(s):

S. Roux ◽

C. Alric ◽

J. Taleb ◽

C. Mandon ◽

C. Billotey ◽

...

Keyword(s):

Computed Tomography ◽

Gold Nanoparticles ◽

Contrast Agents ◽

Computed Tomography Imaging ◽

X Ray ◽

Tomography Imaging ◽

X Ray Computed

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Computed tomography-guided navigated transcranial magnetic stimulation for preoperative brain motor mapping in brain lesion resection: A case report

Surgical Neurology International ◽

10.25259/sni-124-2019 ◽

2019 ◽

Vol 10 ◽

pp. 134 ◽

Cited By ~ 1

Author(s):

Pedro Henrique da Costa Ferreira Pinto ◽

Flavio Nigri ◽

Egas Moniz Caparelli-Dáquer ◽

Jucilana dos Santos Viana

Keyword(s):

Computed Tomography ◽

Transcranial Magnetic Stimulation ◽

Ct Scan ◽

Magnetic Stimulation ◽

Brain Lesion ◽

Immune Deficiency Syndrome ◽

Deficiency Syndrome ◽

Pathology Report ◽

Navigated Transcranial Magnetic Stimulation ◽

Motor Mapping

Background: Navigated transcranial magnetic stimulation (nTMS) is a well establish a noninvasive method for preoperative brain motor mapping. We commonly use magnetic resonance imaging (MRI) to supply the nTMS system. In some cases, MRI is not possible or available, and the use of computed tomography (CT) is necessary. We present the first report describing the association of CT and nTMS motor mapping for brain lesion resection. Case Description: CT imaging of a 59-year-old man suffering from acquired immune deficiency syndrome for 17 years, presenting with seizure and right hemiparesis, revealed a small single hypodense ring-enhancing lesion in the left central sulci suggesting cerebral toxoplasmosis. After 3 weeks of neurotoxoplasmosis treatment, due to four consecutive tonic-clonic seizures, a new CT scan was performed and showed no lesion changes. MRI was in maintenance at that time. Infectious diseases department suggested a brain lesion biopsy. Due to lesion’s location, we decided to perform a presurgical nTMS motor mapping. After a small craniotomy, we could precisely locate and safely totally remove the lesion. The pathology report revealed a high suspicious toxoplasmosis pattern. The patient was discharged after 2 days and continued toxoplasmosis treatment. After 6 months follow-up, he showed no signs of any procedure-related deficits or radiological recurrence. Conclusion: We report the feasibility and applicability of nTMS motor mapping using CT scan as an image source. It gives neurosurgeons another possibility to perform motor mapping for brain lesion removal, especially when MRI is not available or feasible.

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