scholarly journals The Relationship of Dry Eye Disease with Depression and Anxiety: A Naturalistic Observational Study

2018 ◽  
Vol 7 (6) ◽  
pp. 35 ◽  
Author(s):  
Momoko Kitazawa ◽  
Chiaki Sakamoto ◽  
Michitaka Yoshimura ◽  
Motoko Kawashima ◽  
Sachiko Inoue ◽  
...  
Keyword(s):  
Observational Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Depression And Anxiety ◽  
Relationship Of ◽  
The Relationship

scholarly journals The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19

2022 ◽  
Vol 12 ◽  
Author(s):  
Qing He ◽  
Zhuo Chen ◽  
Caiyuan Xie ◽  
Lin Liu ◽  
Ruihua Wei
Keyword(s):  
Sleep Quality ◽  
Dry Eye ◽  
Sleep Latency ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Anxiety And Depression ◽  
Depression And Anxiety ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
The Relationship

Objective: This study aimed to investigate the relationship between dry eye disease (DED) with anxiety and depression. Additionally, the mediating effect of sleep quality on this relationship was explored.Methods: 321 patients with DED were recruited from Tianjin Medical University Eye Hospital clinic and surveyed using demographic questionnaires, the Ocular Surface Disease Index (OSDI), Hospital Anxiety and Depression Scale (HADS), and Pittsburgh Sleep Quality Index (PSQI). Regression analysis and the bootstrap method were used to investigate the influence of sleep on the relationship between DED, anxiety and depression.Results: Among the patients with DED, 86 (26.79%), 85 (26.48%), and 54 (16.82%) patients presented with anxiety, depression, and both anxiety and depression respectively. The OSDI and PSQI score were positively correlated with depression and anxiety (all p < 0.01). The direct effects of OSDI on depression and anxiety were significant (P < 0.01). Additionally, the bootstrap test showed significant mediating effects of subjective sleep quality [95% CI [0.003–0.016] (depression); [0.001–0.011] (anxiety)] and sleep latency [95% CI [0.001–0.010] (depression); [0.001–0.008] (anxiety)]. These results indicated that the severity of DED symptoms, as measured by the OSDI score, affected anxiety and depression through a direct and an indirect pathway mediated by subjective sleep quality and sleep latency.Conclusions: The results indicated that there was a significant correlation between DED and anxiety and depression. Moreover, subjective sleep quality and sleep latency were a mediator of the relationship between DED symptoms and anxiety and depression.

scholarly journals Corneal permeability changes in dry eye disease: an observational study

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Kenji Fujitani ◽  
Neha Gadaria ◽  
Kyu-In Lee ◽  
Brendan Barry ◽  
Penny Asbell
Keyword(s):  
Observational Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Corneal Permeability ◽  
Permeability Changes

scholarly journals Dry Eye Disease following Refractive Surgery: A 12-Month Follow-Up of SMILE versus FS-LASIK in High Myopia

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Bingjie Wang ◽  
Rajeev K. Naidu ◽  
Renyuan Chu ◽  
Jinhui Dai ◽  
Xiaomei Qu ◽  
...  
Keyword(s):  
Observational Study ◽  
Dry Eye ◽  
High Myopia ◽  
Refractive Surgery ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Evaluation Questionnaire

Purpose.To compare dry eye disease following SMILE versus FS-LASIK.Design.Prospective, nonrandomised, observational study.Patients.90 patients undergoing refractive surgery for myopia were included. 47 eyes underwent SMILE and 43 eyes underwent FS-LASIK.Methods.Evaluation of dry eye disease was conducted preoperatively and at 1, 3, 6, and 12 months postoperatively, using the Salisbury Eye Evaluation Questionnaire (SEEQ) and TBUT.Results.TBUT reduced following SMILE at 1 and 3 months (p<0.001) and at 1, 3, and 6 months following FS-LASIK (p<0.001). TBUT was greater following SMILE than FS-LASIK at 3, 6, and 12 months (p<0.001,p<0.001, andp=0.009, resp.). SEEQ scores increased (greater symptoms) following SMILE at 1 month (p<0.001) and 3 months (p=0.003) and at 1, 3, and 6 months following FS-LASIK (p<0.001). SMILE produced lower SEEQ scores (fewer symptoms) than FS-LASIK at 1, 3, and 6 months (p<0.001).Conclusion.SMILE produces less dry eye disease than FS-LASIK at 6 months postoperatively but demonstrates similar degrees of dry eye disease at 12 months.

scholarly journals P2Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Maria-Pia Abbracchio ◽  
Jean-Marie Boeynaems ◽  
José L. Boyer ◽  
Geoffrey Burnstock ◽  
Stefania Ceruti ◽  
...  
Keyword(s):  
Dry Eye ◽  
P2y Receptors ◽  
Eye Disease ◽  
Receptor Subtype ◽  
P2y Receptor ◽  
Uridine Diphosphate ◽  
P2y2 Receptor ◽  
Uridine Triphosphate ◽  
Relationship Of ◽  
The Relationship

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [46, 109, 187, 375, 388].Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [236], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [52, 316].

scholarly journals Dry eye disease and psychiatric disorders: A systematic review and meta-analysis

2021 ◽  
pp. 112067212110609
Author(s):  
Amy Basilious ◽  
Cathy Y Xu ◽  
Monali S Malvankar-Mehta
Keyword(s):  
Dry Eye ◽  
Meta Analysis ◽  
Depression Scale ◽  
Signs And Symptoms ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Depression And Anxiety ◽  
Random Effects Models ◽  
Newcastle Ottawa Scale ◽  
Eye Symptoms

The association between dry eye disease (DED) and psychiatric conditions is a highly researched topic. This work reviews the literature on this relationship, examining the prevalence and correlations of depression and anxiety with dry eye signs and symptoms. A comprehensive literature search of MEDLINE, EMBASE, PsycINFO, and gray literature was conducted, with keywords for dry eye and mood disorders, depression, anxiety, and suicide. Eligible studies underwent quality assessment using the Newcastle-Ottawa Scale. Meta-analysis was performed using STATA 15.0. Fixed- and random-effects models were computed based on the presence of heterogeneity. Thirty-two studies were included, with 31 reporting on depression and 19 on anxiety. Meta-analysis results found a depression prevalence of 40% (CI: [0.29, 0.52]) in DED patients, with 1.81 times higher odds of prevalence compared to controls (CI: [1.61, 2.02]). Prevalence of anxiety was 39% (CI: [0.15, 0.64]), with 2.32 times higher odds of prevalence compared to controls (CI: [1.67, 3.23]). Depression scores were significantly higher in patients with DED in all studies. Anxiety scores were significantly higher in DED patients in studies using all scales except the Hospital Anxiety and Depression Scale-Anxiety Subscale. DED symptom scores were significantly associated with depression (ES = 0.43; CI: [0.31, 0.55]) and anxiety (ES = 0.41; CI: [0.32, 0.50]) scores. In conclusion, depression and anxiety are more prevalent and severe in DED patients and are correlated with dry eye symptoms but not signs. These findings highlight the interrelationship between these disorders and have important implications for providing appropriate care to these patients.

scholarly journals P2Y receptors in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Maria-Pia Abbracchio ◽  
Jean-Marie Boeynaems ◽  
José L. Boyer ◽  
Geoffrey Burnstock ◽  
Stefania Ceruti ◽  
...  
Keyword(s):  
Dry Eye ◽  
P2y Receptors ◽  
Eye Disease ◽  
Receptor Subtype ◽  
P2y Receptor ◽  
Uridine Diphosphate ◽  
P2y2 Receptor ◽  
Uridine Triphosphate ◽  
Relationship Of ◽  
The Relationship

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [47, 110, 190, 383, 396]. Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [241], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [53, 323].

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