scholarly journals P2Y receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Maria-Pia Abbracchio ◽  
Jean-Marie Boeynaems ◽  
José L. Boyer ◽  
Geoffrey Burnstock ◽  
Stefania Ceruti ◽  
...  
Keyword(s):  
Dry Eye ◽  
P2y Receptors ◽  
Eye Disease ◽  
Receptor Subtype ◽  
P2y Receptor ◽  
Uridine Diphosphate ◽  
P2y2 Receptor ◽  
Uridine Triphosphate ◽  
Relationship Of ◽  
The Relationship

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [46, 109, 187, 375, 388].Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [236], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [52, 316].

scholarly journals P2Y receptors in GtoPdb v.2021.3

2021 ◽  
Vol 2021 (3) ◽  
Author(s):  
Maria-Pia Abbracchio ◽  
Jean-Marie Boeynaems ◽  
José L. Boyer ◽  
Geoffrey Burnstock ◽  
Stefania Ceruti ◽  
...  
Keyword(s):  
Dry Eye ◽  
P2y Receptors ◽  
Eye Disease ◽  
Receptor Subtype ◽  
P2y Receptor ◽  
Uridine Diphosphate ◽  
P2y2 Receptor ◽  
Uridine Triphosphate ◽  
Relationship Of ◽  
The Relationship

P2Y receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on P2Y Receptors [3, 5, 192]) are activated by the endogenous ligands ATP, ADP, uridine triphosphate, uridine diphosphate and UDP-glucose. The relationship of many of the cloned receptors to endogenously expressed receptors is not yet established and so it might be appropriate to use wording such as 'uridine triphosphate-preferring (or ATP-, etc.) P2Y receptor' or 'P2Y1-like', etc., until further, as yet undefined, corroborative criteria can be applied [47, 110, 190, 383, 396]. Clinically used drugs acting on these receptors include the dinucleoside polyphosphate diquafosol, agonist of the P2Y2 receptor subtype, approved in Japan for the management of dry eye disease [241], and the P2Y12 receptor antagonists prasugrel, ticagrelor and cangrelor, all approved as antiplatelet drugs [53, 323].

scholarly journals The Relationship of Dry Eye Disease with Depression and Anxiety: A Naturalistic Observational Study

2018 ◽  
Vol 7 (6) ◽  
pp. 35 ◽  
Author(s):  
Momoko Kitazawa ◽  
Chiaki Sakamoto ◽  
Michitaka Yoshimura ◽  
Motoko Kawashima ◽  
Sachiko Inoue ◽  
...  
Keyword(s):  
Observational Study ◽  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Depression And Anxiety ◽  
Relationship Of ◽  
The Relationship

scholarly journals P2Y2 receptor agonists for the treatment of dry eye disease: a review

2014 ◽  
pp. 327 ◽  
Author(s):  
Simon Skalicky ◽  
Oliver Lau ◽  
Chameen Samarawickrama
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
P2y2 Receptor ◽  
Receptor Agonists

scholarly journals Demonstration of functional heterogeneity of hepatic uridine diphosphate glucuronosyltransferase activities after administration of 3-methylcholanthrene and phenobarbital to rats

1978 ◽  
Vol 174 (2) ◽  
pp. 671-672 ◽  
Author(s):  
G J Wishart
Keyword(s):  
Adult Male ◽  
The Other ◽  
Male Rats ◽  
Uridine Diphosphate ◽  
Functional Heterogeneity ◽  
Uridine Diphosphate Glucuronosyltransferase ◽  
Udp Glucuronosyltransferase ◽  
Phenobarbital Administration ◽  
Relationship Of ◽  
The Relationship

After the administration of 3-methylcholanthrene to adult male rats, activities of hepatic UDP-glucuronosyltransferase towards six from a group of 12 substrates were stimulated by 250-350%. Activities towards the remaining six substrates were unaffected. Conversely, after phenobarbital administration, activities formerly stimulated by 3-methylcholanthrene remained unchanged, and the other six activities were stimulated by 160-280%. The relationship of these two groups of transferase activities to other evidence suggesting the same heterogeneity of the enzyme is discussed.

scholarly journals Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease

2021 ◽  
Vol 22 (11) ◽  
pp. 6133
Author(s):  
Aytan Musayeva ◽  
Subao Jiang ◽  
Yue Ruan ◽  
Jenia Kouchek Zadeh ◽  
Panagiotis Chronopoulos ◽  
...  
Keyword(s):  
Inflammatory Cytokines ◽  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
Receptor Subtype ◽  
Redox Enzymes ◽  
Tear Secretion ◽  
Tear Production ◽  
M3 Receptor

The parasympathetic nervous system is critically involved in the regulation of tear secretion by activating muscarinic acetylcholine receptors. Hence, various animal models targeting parasympathetic signaling have been developed to induce dry eye disease (DED). However, the muscarinic receptor subtype (M1–M5) mediating tear secretion remains to be determined. This study was conducted to test the hypothesis that the M3 receptor subtype regulates tear secretion and to evaluate the ocular surface phenotype of mice with targeted disruption of the M3 receptor (M3R−/−). The experimental techniques included quantification of tear production, fluorescein staining of the ocular surface, environmental scanning electron microscopy, assessment of proliferating cells in the corneal epithelium and of goblet cells in the conjunctiva, quantification of mRNA for inflammatory cytokines and prooxidant redox enzymes and quantification of reactive oxygen species. Tear volume was reduced in M3R−/− mice compared to age-matched controls at the age of 3 months and 15 months, respectively. This was associated with mild corneal epitheliopathy in the 15-month-old but not in the 3-month-old M3R−/− mice. M3R−/− mice at the age of 15 months also displayed changes in corneal epithelial cell texture, reduced conjunctival goblet cell density, oxidative stress and elevated mRNA expression levels for inflammatory cytokines and prooxidant redox enzymes. The findings suggest that the M3 receptor plays a pivotal role in tear production and its absence leads to ocular surface changes typical for DED at advanced age.

scholarly journals The Relationship Between Dry Eye Disease and Digital Screen Use

2021 ◽  
Vol Volume 15 ◽  
pp. 3811-3820
Author(s):  
Zaina Al-Mohtaseb ◽  
Scott Schachter ◽  
Bridgitte Shen Lee ◽  
Jaclyn Garlich ◽  
William Trattler
Keyword(s):  
Dry Eye ◽  
Dry Eye Disease ◽  
Eye Disease ◽  
The Relationship ◽  
Screen Use
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