Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis

Objective: Growing evidence shows that oxidative stress plays an important role in the development and progression of nephrotic syndrome (NS). In this study, we aimed to examine serum IMA levels as an indicator of oxidative stress in children with steroid-sensitive NS (SSNS) in remission and relapse. Methods: This cross-sectional study was carried out at the Pediatric Nephrology Unit of Sanliurfa Training and Research Hospital, Sanliurfa, Turkey, from April 2019 to December 2019. In this study Serum IMA and albumin levels were determined in 70 children with SSNS and 45 healthy controls. Among the children with SSNS, 50 were in remission and 20 were in relapse. Then, adjusted IMA levels were calculated from the IMA/albumin ratio. Results: IMA and adjusted IMA levels significantly increased and albumin significantly decreased in children with SSNS in relapse and remission compared with those of the healthy controls. Moreover, these alterations were more prominent in the relapse group than in the remission group. IMA was inversely correlated with albumin in children with SSNS (r= −0.881, p= <0.001). Conclusions: Our findings demonstrated that elevated IMA and adjusted IMA levels observed in patients with SSNS were associated with increased oxidative stress and could indirectly reflect the degree of oxidative damage in glomerular structures. doi: https://doi.org/10.12669/pjms.36.7.2924 How to cite this:Cakirca G, Guzelcicek A, Yilmaz K, Nas C. Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2924 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Oxidative stress in childhood steroid sensitive nephrotic syndrome and its correlation with DNA damage

International Journal of Contemporary Pediatrics ◽

10.18203/2349-3291.ijcp20161853 ◽

2016 ◽

pp. 768-772

Author(s):

Priyanka Reddy ◽

Seema Sindgikar ◽

Rathika Shenoy ◽

Vijaya Shenoy

Keyword(s):

Oxidative Stress ◽

Dna Damage ◽

Nephrotic Syndrome ◽

Plasma levels of oxidative stress in children with steroid-sensitive nephrotic syndrome and their predictive value for relapse frequency

Pediatric Nephrology ◽

10.1007/s00467-015-3195-2 ◽

2015 ◽

Vol 31 (1) ◽

pp. 83-88 ◽

Cited By ~ 2

Author(s):

Aiwen Fan ◽

Xiaoyun Jiang ◽

Ying Mo ◽

Huizhen Tan ◽

Mengjie Jiang ◽

...

Keyword(s):

Oxidative Stress ◽

Nephrotic Syndrome ◽

Predictive Value ◽

Plasma Levels ◽

Centromere protein I (CENPI) is a candidate gene for X-linked steroid sensitive nephrotic syndrome

Journal of Nephrology ◽

10.1007/s40620-019-00692-1 ◽

2020 ◽

Vol 33 (4) ◽

pp. 763-769 ◽

Cited By ~ 2

Author(s):

Sulman Basit ◽

Howaida Mohammed Al-Edressi ◽

Mona Hamza Sairafi ◽

Jamil Amjad Hashmi ◽

Essa Alharby ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Candidate Gene ◽

Centromere Protein ◽

Steroid treatment for the first episode of childhood nephrotic syndrome: comparison of the 8 and 12 weeks regimen using an individual patient data meta-analysis

European Journal of Pediatrics ◽

10.1007/s00431-021-04035-w ◽

2021 ◽

Author(s):

Anne M. Schijvens ◽

Nynke Teeninga ◽

Eiske M. Dorresteijn ◽

Steven Teerenstra ◽

Nicholas J. Webb ◽

...

Keyword(s):

Nephrotic Syndrome ◽

Individual Patient Data ◽

Meta Analysis ◽

Steroid Treatment ◽

First Episode ◽

Childhood Nephrotic Syndrome ◽

Steroid Sensitive ◽

First Relapse ◽

Steroid Regimen

AbstractSteroids are the cornerstone of the treatment of childhood nephrotic syndrome. The optimal duration for the first episode remains a matter of debate. The aim of this study is to determine whether the 8 weeks International Study of Kidney Disease in Children (ISKDC) regimen is equally effective as the 12 weeks steroid regimen from the German society of pediatric nephrology (Arbeitsgemeinschaft für Pädiatrische Nephrologie [APN]). An individual patient data (IPD) meta-analysis of randomized controlled trials reporting on prednisolone treatment for a first episode of childhood nephrotic syndrome was conducted. European trials aimed at investigating the ISKDC and/or APN steroid regimen were selected. The lead investigators of the selected trials were requested to provide the IPD of the specific treatment groups. Four trials included European cohorts using dosing schedules according to the regimens studied. IPD of two trials were available. A significant difference was found in time to first relapse after cessation of steroid treatment between the 8 and 12 weeks treatment group with a median time to relapse of 29 and 63 days, respectively. Moreover, relapse rate ratios during total follow-up were 51% higher for the 8 weeks regimen. Finally, younger children have a significantly lower time to first relapse and frequently relapsing nephrotic syndrome.Conclusions: The results of this IPD meta-analysis suggest that the 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen. Moreover, this study highlights the importance of using uniform definitions to enable accurate comparison and interpretation of trial results.Trial registration: Registration number: CRD42020199244, date of registration 16-08-2020 What is Known:• Steroids are the cornerstone of the treatment of childhood nephrotic syndrome, however the optimal duration for the first episode remains a matter of debate.• Currently, the 8 weeks ISKDC protocol and 12 weeks APN protocol are among the most frequently used protocols in Europe. What is New:• The 8 weeks steroid regimen for a first episode of steroid-sensitive nephrotic syndrome may not be equally effective as the 12 weeks steroid regimen for the treatment of a first episode of nephrotic syndrome.• Younger children have a significantly shorter time to first relapse and time to frequent relapsing nephrotic syndrome.

Distribution of serum adiponectin isoforms in pediatric patients with steroid-sensitive nephrotic syndrome

Clinical and Experimental Nephrology ◽

10.1007/s10157-021-02085-w ◽

2021 ◽

Author(s):

Tetsuro Tamai ◽

Kaori Kamijo ◽

Yoshifusa Abe ◽

Satoshi Hibino ◽

Shunsuke Sakurai ◽

...

Keyword(s):

Molecular Weight ◽

Nephrotic Syndrome ◽

Pediatric Patients ◽

Serum Adiponectin ◽

Total Serum ◽

Control Subjects ◽

Remission Period ◽

Total Adiponectin ◽

Abstract Background Serum adiponectin circulates in three multimeric isoforms: high-molecular-weight (HMW), middle-molecular-weight (MMW), and low-molecular-weight (LMW) isoforms. Potential change in the circulating adiponectin levels in patients with nephrotic syndrome (NS) remain unknown. This study aimed to assess the levels of total adiponectin and the distribution of its isoforms in pediatric patients with NS. Methods We sequentially measured total adiponectin and each adiponectin isoform levels at the onset of NS, initial remission, and during the remission period of the disease in 31 NS patients. We also calculated the ratios of HMW (%HMW), MMW (%MMW), and LMW (%LMW) to total adiponectin incuding 51 control subjects. Results The median of total serum adiponectin levels in patients were 36.7, 36.7, and 20.2 μg/mL at the onset, at initial remission, and during the remission period of NS, respectively. These values were significantly higher than those in control subjects. The median values of %HMW, %MMW, and %LMW values were 56.9/27.0/14.1 at the onset, 62.0/21.8/13.4 at the initial remission, and 58.1/21.7/17.5 at during the remission period of NS, respectively. Compared with control subjects, %HMW at initial remission and %MMW at the onset were high, and the %LMW values at the onset and at initial remission were low. Conclusions In patients with NS, total serum adiponectin levels increase at the onset of the disease, and the ratio of adiponectin isoforms changes during the course of the disease. Further studies are needed to delineate the mechanisms between proteinuria and adiponectin isoforms change.