scholarly journals Islet transplantation into brown adipose tissue can delay immune rejection

JCI Insight ◽  
2022 ◽  
Author(s):  
Jessica D. Kepple ◽  
Jessie M. Barra ◽  
Martin E. Young ◽  
Chad S. Hunter ◽  
Hubert M. Tse
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Islet Transplantation ◽  
Immune Rejection ◽  
Brown Adipose

Brown Adipose Tissue: A Potential Site for Islet Transplantation

2020 ◽  
Vol 104 (10) ◽  
pp. 2059-2064 ◽  
Author(s):  
Kang Xu ◽  
Raoying Xie ◽  
Xiaolin Lin ◽  
Junshuang Jia ◽  
Nan Zeng ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Islet Transplantation ◽  
Potential Site ◽  
Brown Adipose

1686-P: Brown Adipose Tissue as a Novel Site for Islet Transplantation

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1686-P
Author(s):  
JESSIE BARRA ◽  
JESSICA KEPPLE ◽  
HUBERT M. TSE ◽  
CHAD S. HUNTER
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Islet Transplantation ◽  
Brown Adipose

164-OR: Brown Adipose Tissue as a Novel Site for Islet Transplantation

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 164-OR
Author(s):  
JESSICA KEPPLE ◽  
JESSIE BARRA ◽  
CHAD S. HUNTER ◽  
HUBERT M. TSE
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Islet Transplantation ◽  
Brown Adipose

Functional characterization of human brown adipose tissue metabolism

2020 ◽  
Vol 477 (7) ◽  
pp. 1261-1286 ◽  
Author(s):  
Marie Anne Richard ◽  
Hannah Pallubinsky ◽  
Denis P. Blondin
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Functional Characterization ◽  
Human Infants ◽  
Positron Emission ◽  
Brown Adipose ◽  
Treatment Of Obesity ◽  
And Function

Brown adipose tissue (BAT) has long been described according to its histological features as a multilocular, lipid-containing tissue, light brown in color, that is also responsive to the cold and found especially in hibernating mammals and human infants. Its presence in both hibernators and human infants, combined with its function as a heat-generating organ, raised many questions about its role in humans. Early characterizations of the tissue in humans focused on its progressive atrophy with age and its apparent importance for cold-exposed workers. However, the use of positron emission tomography (PET) with the glucose tracer [18F]fluorodeoxyglucose ([18F]FDG) made it possible to begin characterizing the possible function of BAT in adult humans, and whether it could play a role in the prevention or treatment of obesity and type 2 diabetes (T2D). This review focuses on the in vivo functional characterization of human BAT, the methodological approaches applied to examine these features and addresses critical gaps that remain in moving the field forward. Specifically, we describe the anatomical and biomolecular features of human BAT, the modalities and applications of non-invasive tools such as PET and magnetic resonance imaging coupled with spectroscopy (MRI/MRS) to study BAT morphology and function in vivo, and finally describe the functional characteristics of human BAT that have only been possible through the development and application of such tools.

Brown adipose tissue (BAT) can normalize hyperglycemia and hypertriglyceridemia in mice

2011 ◽  
Vol 6 (S 01) ◽  
Author(s):  
M Merkel ◽  
A Bartelt ◽  
K Brügelmann ◽  
J Heeren
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

The influence of thyroid dysfunction on the activity of brown adipose tissue in mice detected by [18F]FDG PET/MR

2014 ◽  
Vol 9 (S 01) ◽  
Author(s):  
K Krause ◽  
M Kranz ◽  
V Zeisig ◽  
N Klöting ◽  
K Steinhoff ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Fdg Pet ◽  
Thyroid Dysfunction ◽  
Brown Adipose ◽  
18F Fdg

Nesfatin-1 employs the central melanocortin pathway to stimulate non-shivering thermogenesis in brown adipose tissue (BAT)

2017 ◽  
Vol 12 (S 01) ◽  
pp. S1-S84
Author(s):  
L Levata ◽  
R Dore ◽  
O Jöhren ◽  
H Lehnert ◽  
C Schulz
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Shivering Thermogenesis

P53 regulates the lipid metabolism response to metabolic stress in brown adipose tissue

2020 ◽  
Author(s):  
G Lenihan-Geels ◽  
F Garcia-Carrizo ◽  
C Li ◽  
M Oster ◽  
A Prokesch ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipid Metabolism ◽  
Brown Adipose Tissue ◽  
Metabolic Stress ◽  
Brown Adipose
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