scholarly journals AMINO ACID EXTRACTION AND AMMONIA METABOLISM BY THE HUMAN KIDNEY DURING THE PROLONGED ADMINISTRATION OF AMMONIUM CHLORIDE*

1963 ◽  
Vol 42 (2) ◽  
pp. 263-276 ◽  
Author(s):  
Edward E. Owen ◽  
Roscoe R. Robinson
Keyword(s):  
Amino Acid ◽  
Ammonium Chloride ◽  
Human Kidney ◽  
Acid Extraction ◽  
Prolonged Administration ◽  
Ammonia Metabolism

scholarly journals Systemic muscle wasting and coordinated tumour response drive tumourigenesis

2019 ◽  
Author(s):  
Holly Newton ◽  
Yi-Fang Wang ◽  
Laura Camplese ◽  
André E.X. Brown ◽  
Susumu Hirabayashi
Keyword(s):  
Amino Acid ◽  
Tumour Growth ◽  
Muscle Wasting ◽  
Human Cancer ◽  
Tumour Response ◽  
Human Kidney ◽  
Amino Acid Derivative ◽  
Database Analysis ◽  
Powerful Approach ◽  
Transporter Expression

SUMMARYCancer cells demand excess nutrients to support their proliferation, but how tumours exploit extracellular amino acids during systemic metabolic pertubations remain incompletely understood. Here we use a Drosophila model of obesity-enhanced tumourigenesis to uncover a systemic host-tumour nutrient circuit that supports tumour growth. We demonstrate coordinate induction of systemic cachexia-like muscle wasting with tumour-autonomous SLC36-family amino acid transporter expression as a proline-scavenging programme to drive tumourigenesis. This coordinated induction of cachexia and SLC36-transporters pertains to human kidney cancer and associates with significantly worse survival outcomes. We identify Indole-3-propionic acid as an optimal amino acid derivative to rationally target the proline-dependency of tumour growth. Combining insights from whole-animal Drosophila models and human cancer database analysis provides a powerful approach towards the identification and therapeutic exploitation of the amino acid vulnerabilities of tumourigenesis in the context of perturbed systemic metabolic network.

The removal of contaminating Quadrol by boric acid extraction prior to mass spectral analysis of amino acid thiazolinones

1975 ◽  
Vol 66 (2) ◽  
pp. 623-626 ◽  
Author(s):  
Ruth L. Guyer ◽  
William C. Schnute ◽  
Charles W. Todd ◽  
Robert E. Lovins
Keyword(s):  
Spectral Analysis ◽  
Amino Acid ◽  
Boric Acid ◽  
Acid Extraction ◽  
Mass Spectral Analysis ◽  
Mass Spectral

Study and Optimization of Amino Acid Extraction by Emulsion Liquid Membrane

2008 ◽  
Vol 43 (11-12) ◽  
pp. 3075-3096 ◽  
Author(s):  
E. Mohagheghi ◽  
I. Alemzadeh ◽  
M. Vossoughi
Keyword(s):  
Amino Acid ◽  
Liquid Membrane ◽  
Acid Extraction ◽  
Emulsion Liquid Membrane

Effects of methionine sulphoximine treatment on renal amino acid and ammonia metabolism in rats

1994 ◽  
Vol 427 (5-6) ◽  
pp. 524-532 ◽  
Author(s):  
Sylvia Heeneman ◽  
Cornelis H. C. Dejong ◽  
Nicolaas E. P. Deutz
Keyword(s):  
Amino Acid ◽  
Ammonia Metabolism ◽  
Methionine Sulphoximine

scholarly journals Studies on the primary structure of chicken erythrocyte histone fraction V

1971 ◽  
Vol 124 (2) ◽  
pp. 319-325 ◽  
Author(s):  
P. J. Greenaway
Keyword(s):  
Amino Acid ◽  
Amino Acid Sequence ◽  
Primary Structure ◽  
Sequence Data ◽  
Acid Extraction ◽  
Chicken Erythrocyte ◽  
Histone Fraction

Histone fraction V was prepared by selective acid extraction from chicken erythrocyte nuclei. Amino acid sequence studies on the tryptic and thermolytic peptides are reported. Only a limited amount of overlapping sequence data was obtained.

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