New Findings on Antipsychotic Use in Children and Adolescents With Schizophrenia Spectrum Disorders

2008 ◽  
Vol 165 (11) ◽  
pp. 1369-1372 ◽  
Author(s):  
Randal G. Ross
2005 ◽  
Vol 100 (3_suppl) ◽  
pp. 1097-1106 ◽  
Author(s):  
James McCarthy ◽  
Keith Kraseski ◽  
Inika Schvartz ◽  
Veronica Mercado ◽  
Nicole Daisy ◽  
...  

To investigate the cognitive functioning of children and adolescents with Schizophrenia Spectrum disorders and Psychosis Not Otherwise Specified, 22 child and adolescent psychiatric inpatients and day-hospital patients at a state psychiatric hospital with Schizophrenia Spectrum disorders, 30 with Psychosis Not Otherwise Specified, and 130 with other psychiatric disorders, ages 8 to 17 years, were administered the Wechsler Intelligence Scale for Children–III for psychological assessment at admission. The Performance IQs of the ADHD and the Conduct Disorder and Oppositional Defiant Disorder groups were significantly higher than those of the Schizophrenia Spectrum and the Psychosis Not Otherwise Specified groups, and the Full Scale IQs of the Conduct Disorder and Oppositional Defiant Disorder group were significantly higher than those of the Schizophrenia Spectrum group and the Psychosis Not Otherwise Specified group. The Coding scores of the ADHD group were significantly higher than those of the Schizophrenia Spectrum, the Psychosis Not Otherwise Specified, and the Bipolar Disorder groups. There was a significant negative correlation between age and Digit Span for the Schizophrenia Spectrum disorders group.


2017 ◽  
Vol 6 (2) ◽  
pp. 141-157
Author(s):  
A. Sergienko

The article describes the neuropsychological techniques which are applied in the clinical practice in child psychiatry. It describes a system of qualitative and quantitative neuropsychological diagnostics. The role of neuropsychological analysis of the cognitive deficits associated with schizophrenia spectrum disorders in children and adolescents is reflected. Hierarchical cluster analysis according to neuropsychological diagnosis helps in the establishing the psychiatric diagnosis.


2015 ◽  
Vol 6 (4) ◽  
pp. 112-115
Author(s):  
Aleksey Anatol'yevich Sergienko ◽  
Svetlana Evgen'yevna Strogova ◽  
Natalia Vladimirovna Zvereva

This article presents a compound neuropsychological/psychometric analysis of manifestations of defects in children and adolescents with endogenous pathologies. The research was organized among children with diagnosed schizophrenia spectrum disorders: child type schizophrenia, schizotypal personality disorder and other forms of schizophrenia. All patients were on the stationary treatment and had verified diagnosis, defect in cognitive sphere was close to oligofrenic like defect. The experimental group (EG) - 74 children (52 boys), average age - 11,0 ± 2,9 years. Control group (CG) - children and adolescents (64 children, among them 38 boys) from Moscow schools, average age - 11,1 ± 3,0 years. The neuropsychological research was taken on 20 children from EG and on 15 children from CG. Qualitative and quantitative analyses of data included the formulation of criteria of marks of the psychometric and neuropsychological results. Based on our research data we distinguish specific compounds of manifestations of certain cerebrum structure dysfunctions and cognitive dysfunctions that are common in children with schizophrenia spectrum disorders. We also illustrate the differences in localization (in interhemispheric cooperation, cortical structures, subcortical structures) of primary dysfunctions in patients diagnosed with various schizophrenia spectrum disorders. Neuropsychological and psychometric analysis had shown that patients by their functional status are heterogeneous group. The defection of intellectual activity is not total but partial with gradual involvement of different aspects.


2016 ◽  
Vol 5 (1) ◽  
pp. 61-76 ◽  
Author(s):  
S. Strogova ◽  
A. Sergienko ◽  
N.V. Zvereva

The article is devoted to the diagnostic approaches of cognitive defects in schizophrenia using psychometric and neuropsychological methods. The clinical psychological research results of different kinds of cognitive defects in children and adolescents with schizophrenia spectrum disorders (74 subjects of average age of 11 ± 2 years old, 18 of which have passed a complete neuropsychological examination) are described. We have compared psychrometric and neuropsychological diagnostics results of children and adolescents with schizophrenia spectrum disorders with the results of reference group of children with normal development. The differences of intellectual levels depending on the diagnosis have been marked and the respective types of cognitive defect are described. The total (most severe) defect has been detected in children with progredient schizophrenia (F20). While in other groups (children and adolescents with non-progredient schizophrenia) there has been revealed partial defect. Complex psychometric and neuropsychological diagnostics allows to make more detailed evaluation of the cognitive defect and its structure. Neuropsychological diagnostics has also confirmed that there are intensity differences of brain dysfunction between the diagnosed groups. Patients with сhildren schizophrenia (F20) have notable dysfunctions (or functional immaturity) of cortical structures, while in the group of children with diagnosis of episodic schizophrenia (episodic with progressive clinical course) with progressive or stable defect (F20.x) impairment of interhemispheric coordination has been observed. Children and adolescents with schizotypal disorder (F21) have showed dysfunctions of subcortical structures. Our research results support the hypotheses about the interrelation between kinds of cognitive defect and specificity of neuropsychological status in children and adolescents with different kinds of progredient schizophrenia spectrum disorders.


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