Measurement-Based Care Versus Standard Care for Major Depression: A Randomized Controlled Trial With Blind Raters

2015 ◽  
Vol 172 (10) ◽  
pp. 1004-1013 ◽  
Author(s):  
Tong Guo ◽  
Yu-Tao Xiang ◽  
Le Xiao ◽  
Chang-Qing Hu ◽  
Helen F.K. Chiu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Major Depression ◽  
Standard Care ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Measurement Based Care

Nepeta menthoides Boiss. & Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: a double blind randomized controlled trial

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
S Kolouri ◽  
A Firoozabadi ◽  
A Salehi ◽  
MM Zarshenas ◽  
SA Dastgheib ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Major Depression ◽  
Aqueous Extract ◽  
Controlled Trial ◽  
Double Blind ◽  
Randomized Controlled ◽  
Freeze Dried

scholarly journals EFFECT OF CORNEAL CROSS-LINKING vs STANDARD CARE ON KERATOCONUS PROGRESSION IN YOUNG PATIENTS: THE KERALINK RANDOMIZED CONTROLLED TRIAL

Ophthalmology ◽  
2021 ◽  
Author(s):  
Daniel F.P. Larkin ◽  
Kashfia Chowdhury ◽  
Jennifer M. Burr ◽  
Mathew Raynor ◽  
Matthew Edwards ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Standard Care ◽  
Controlled Trial ◽  
Young Patients ◽  
Cross Linking ◽  
Randomized Controlled

scholarly journals Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement

2016 ◽  
Vol 34 (16) ◽  
pp. 1921-1927 ◽  
Author(s):  
David W. Kissane ◽  
Talia I. Zaider ◽  
Yuelin Li ◽  
Shira Hichenberg ◽  
Tammy Schuler ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Family Therapy ◽  
Advanced Cancer ◽  
Standard Care ◽  
Controlled Trial ◽  
Significant Treatment ◽  
Prolonged Grief Disorder ◽  
Prolonged Grief ◽  
Randomized Controlled ◽  
High Conflict

Purpose Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Patients and Methods Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center or three related community hospice programs, 620 patients (42%) were recruited, which represented 170 families. Families were stratified by three levels of family dysfunction (low communicating, low involvement, and high conflict) and randomly assigned to one of three arms: standard care or 6 or 10 sessions of a manualized family intervention. Primary outcomes were the Complicated Grief Inventory-Abbreviated (CGI) and Beck Depression Inventory-II (BDI-II). Generalized estimating equations allowed for clustered data in an intention-to-treat analysis. Results On the CGI, a significant treatment effect (Wald χ2 = 6.88; df = 2; P = .032) and treatment by family-type interaction was found (Wald χ2 = 20.64; df = 4; P < .001), and better outcomes resulted from 10 sessions compared with standard care for low-communicating and high-conflict groups compared with low-involvement families. Low-communicating families improved by 6 months of bereavement. In the standard care arm, 15.5% of the bereaved developed a prolonged grief disorder at 13 months of bereavement compared with 3.3% of those who received 10 sessions of intervention (Wald χ2 = 8.31; df = 2; P =.048). No significant treatment effects were found on the BDI-II. Conclusion Family-focused therapy delivered to high-risk families during palliative care and continued into bereavement reduced the severity of complicated grief and the development of prolonged grief disorder.

Defining Optimal Care for Functional Gut Disorders - Multi-Disciplinary Versus Standard Care: A Randomized Controlled Trial Protocol

2019 ◽  
Vol 84 ◽  
pp. 105828 ◽  
Author(s):  
Chamara Basnayake ◽  
Michael A. Kamm ◽  
Michael Salzberg ◽  
Angela Khera ◽  
Danny Liew ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Standard Care ◽  
Controlled Trial ◽  
Trial Protocol ◽  
Optimal Care ◽  
Randomized Controlled

scholarly journals Treating depression with a smartphone-delivered self-help cognitive behavioral therapy for insomnia: study protocol for a parallel group randomized controlled trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Victoria Ka-Ying Hui ◽  
Christy Yim-Fan Wong ◽  
Eric Ka-Yiu Ma ◽  
Fiona Yan-Yee Ho ◽  
Christian S. Chan
Keyword(s):  
Randomized Controlled Trial ◽  
Hong Kong ◽  
Major Depression ◽  
Cognitive Behavioral Therapy ◽  
Behavioral Therapy ◽  
Controlled Trial ◽  
Smartphone Application ◽  
Cognitive Behavioral ◽  
Randomized Controlled ◽  
Self Help

Abstract Background Depression is a major public health concern. Emerging research has shown that cognitive behavioral therapy for insomnia (CBT-I) is effective in treating individuals with comorbid insomnia and depression. Traditional face-to-face CBT-I encounters many obstacles related to feasibility, accessibility, and help-seeking stigma. CBT-I delivered via smartphone application could be a potential solution. This paper reports a protocol designed to evaluate the efficacy of a self-help smartphone-based CBT-I, using a waitlist group as control, for people with major depression and insomnia. Methods A two-arm parallel randomized controlled trial is conducted in a target sample of 285 non-suicidal Hong Kong Chinese older than 17 years of age with major depression and insomnia. Participants complete an online rapid screening, followed by a telephone diagnostic interview. Those who meet the eligibility criteria are randomized in a ratio of 1:1 to receive either CBT-I immediately or to a waitlist control condition. The CBT-I consists of six weekly modules and is delivered through a smartphone application proACT-S. This smartphone app has been pilot tested and revamped to improve user experience. An online randomized algorithm is used to perform randomization to ensure allocation concealment. The primary outcomes are changes over the measurement points in sleep quality, insomnia severity, and depression severity. The secondary outcomes include changes over the measurement points in anxiety, subjective health, treatment expectancy, and acceptability of treatment. Assessments are administered at baseline, post-intervention, and 6-week follow-up. The recruitment is completed. Important adverse events, if any, are documented. Multilevel linear mixed model based on intention-to-treat principle will be conducted to examine the efficacy of the CBT-I intervention. Discussion It is expected that proACT-S is an efficacious brief sleep-focused self-help treatment for people with major depression and insomnia. If proven efficacious, due to its self-help nature, proACT-S may be applicable as a community-based early intervention, thereby reducing the burden of the public healthcare system in Hong Kong. Trial registration ClinicalTrials.gov NCT04228146. Retrospectively registered on 14 January 2020.

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