Delayed Hematogenous Metastasis Versus Second Primary Squamous Cell Carcinoma of the Neck in a Patient With Previous Cancer of the Cervix

2021 ◽  
pp. 000313482110604
Author(s):  
Peter Coriell ◽  
Kevin Engledow ◽  
Shailja Roy ◽  
Glenda Smith ◽  
Nadia Nashed ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neck Mass ◽  
Second Primary ◽  
Supraclavicular Lymph Node ◽  
Neck Metastasis ◽  
High Risk Hpv

Squamous cell carcinoma (SCC) of the uterine cervix commonly spreads through direct infiltration and disseminates by lymphatic or hematogenous pathways. The most frequent locations for metastasis are lungs, liver, and bone. Other distant metastatic sites are rare, with only 1 reported case of neck metastasis. We present here a 73-year-old female with a prior human papillomavirus (HPV) + SCC of the cervix that had metastasized to her peri-aortic lymph nodes. Eight years after diagnosis and treatment, she returned with a hypermetabolic supraclavicular lymph node and new left-sided neck mass. Biopsy of the neck mass revealed invasive SCC positive for high-risk HPV genotype. The presence of high-risk HPV genotypes in both the cervix and supraclavicular lymph node, without evidence of second primary tumor, implies that the neck mass is a delayed metastasis of the patient’s previous cervical cancer. This marks the second recorded case of neck metastasis from a SCC of the cervix.

scholarly journals Correlation of EGFR, pEGFR and p16INK4 expressions and high risk HPV infection in HIV/AIDS-related squamous cell carcinoma of conjunctiva

2014 ◽  
Vol 9 (1) ◽  
pp. 7 ◽  
Author(s):  
Anthony Mwololo ◽  
Joshua Nyagol ◽  
Emily Rogena ◽  
Willis Ochuk ◽  
Mary Kimani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Hpv Infection ◽  
High Risk Hpv ◽  
Hiv Aids

scholarly journals p16 expression in cutaneous squamous cell carcinoma of the head and neck is not associated with integration of high risk HPV DNA or prognosis

Pathology ◽  
2017 ◽  
Vol 49 (5) ◽  
pp. 494-498 ◽  
Author(s):  
Laveniya Satgunaseelan ◽  
Noel Chia ◽  
Hyerim Suh ◽  
Sohaib Virk ◽  
Bruce Ashford ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Hpv Dna ◽  
High Risk Hpv ◽  
P16 Expression

High-risk HPV and survival in patients with oral and oropharyngeal squamous cell carcinoma – 5-year follow up of a population-based study

2014 ◽  
Vol 134 (8) ◽  
pp. 843-851 ◽  
Author(s):  
Karin Annertz ◽  
Kerstin Rosenquist ◽  
Gunilla Andersson ◽  
Helene Jacobsson ◽  
Bengt Göran Hansson ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Population Based ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Population Based Study ◽  
High Risk Hpv

Preoperative18F-FDG PET/CT and high-risk HPV in patients with oropharyngeal squamous cell carcinoma

Head & Neck ◽  
2013 ◽  
Vol 36 (3) ◽  
pp. 323-327 ◽  
Author(s):  
Young-Hoon Joo ◽  
Ie-Ryung Yoo ◽  
Kwang-Jae Cho ◽  
Jun-Ook Park ◽  
In-Chul Nam ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Oropharyngeal Squamous Cell Carcinoma ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
High Risk Hpv

Association between the standardized uptake value and high-risk HPV in hypopharyngeal squamous cell carcinoma

2014 ◽  
Vol 134 (10) ◽  
pp. 1062-1070 ◽  
Author(s):  
Young-Hoon Joo ◽  
Ie-Ryung Yoo ◽  
Youn-Soo Lee ◽  
Kwang-Jae Cho ◽  
Jun-Ook Park ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Standardized Uptake Value ◽  
Hypopharyngeal Squamous Cell Carcinoma ◽  
High Risk Hpv

P179 High risk HPV infection is associated with oral squamous cell carcinoma in Mexican patients: a case control study

2007 ◽  
Vol 2 (1) ◽  
pp. 185
Author(s):  
G. Anaya-Saavedra ◽  
V.A. Ramírez-Amador ◽  
M.E. Irigoyen-Camacho ◽  
C.M. García-Cuellar ◽  
A. García-Cuellar
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Case Control Study ◽  
Hpv Infection ◽  
Case Control ◽  
High Risk Hpv ◽  
Control Study

scholarly journals Validation for a novel diagnostic standard in HPV-positive oropharyngeal squamous cell carcinoma.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 5543-5543
Author(s):  
Xiao-Jun Ma ◽  
Andrew Schache ◽  
Triantafilos Liloglou ◽  
Janet Risk ◽  
Terence Jones ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Sensitivity And Specificity ◽  
Squamous Cell ◽  
Gold Standard ◽  
Standard Test ◽  
Kaplan Meier ◽  
High Risk Hpv ◽  
Oncogenic Hpv

5543 Background: HPV testing is now widely advocated in the work up of oropharyngeal squamous cell carcinoma (OPSCC). The "gold standard" for oncogenic HPV detection is the demonstration of transcriptionally active high-risk HPV in fresh tumour tissue. For clinical utility, testing strategies have necessarily focused on formalin-fixed paraffin-embedded (FFPE) tissue, but this has been at the expense of reduced sensitivity and specificity for oncogenic HPV. This study evaluates a novel RNA-based in situ hybridisation test against the analytical gold standard; detection of high-risk HPV mRNA, derived from fresh frozen tissue samples, by quantitative reverse transcriptase polymerase chain reaction (qPCR). Methods: A tissue-microarray comprising FFPE cores from 79 OPSCC was tested using High Risk HPV RNAscope (Advanced Cell Diagnostics, USA) for HPV16, 18, 31, 33, 35, 52, and 58. Analytical accuracy and capacity for prognostic discrimination was determined by comparison with HPV RNA qPCR for HPV16, 18 and 33. Demographic and tumour parameters were compared by Chi-squared and Kruskal-Wallis tests. Test sensitivity and specificity were calculated against the standard. Kaplan–Meier survival estimates were constructed to assess prognostication. Results: High risk HPV RNAscope had sensitivity and specificity of 97% and 93% respectively (PPV 91%, NPV 98%) by comparison to the gold standard. Kaplan-Meier estimates of disease specific survival (DSS, p=0.002) and overall survival (OS, p<0.001) by RNAscope were similar to the gold standard (DSS, p=0.006, OS, p=0.002) and superior to p16 immunohistochemistry (IHC) or the combination of p16 IHC and DNA qPCR. Conclusions: We demonstrated that High Risk HPV RNAscope can be used to detect oncogenic HPV in FFPE OPSCC samples and has both excellent analytical and prognostic performance against the gold standard test for oncogenic HPV. These results raise the possibility that High Risk HPV RNAscope could be adopted as an ‘international standard’ test for OPSCC in clinical practice. As the oncology community approaches therapeutic de-escalation based on HPV status, such a reliable and efficacious test may have immediate application.

Sign in / Sign up

Export Citation Format

Share Document