Adrenal Cortical Adenoma and Adrenal Medullary Hyperplasia of the Right Adrenal Gland—A Case Report

We present a case of Cushings syndrome and virilization in a 15 year old girl which was suspected to be due to an adrenal carcinoma. She presented with features of virilization in addition to those of hypercortisilism. Her high androgen levels especially dehydroepiandrosterone sulfate (DHEAS) were also in favor of an adrenal carcinoma. An unenhanced computerized tomography (CT) scan showed a mass (size: 5.3 cm) in the right adrenal gland with a soft tissue intensity of more than 10 HU which was suggestive of adrenal carcinoma. But, histopathology of the resected mass revealed a benign adrenocortical adenoma. DOI: http://dx.doi.org/10.3329/imcj.v6i2.14736 Ibrahim Med. Coll. J. 2012; 6(2): 70-72

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A case report of metastatic neuroendocrine carcinoma of the right adrenal gland successfully treated with chemotherapy and surgery

International Journal of Clinical Oncology ◽

10.1007/s10147-010-0051-z ◽

2010 ◽

Vol 15 (4) ◽

pp. 423-427 ◽

Cited By ~ 3

Author(s):

Toshiya Ochiai ◽

Sosuke Komiyama ◽

Hisashi Ikoma ◽

Takeshi Kubota ◽

Masayoshi Nakanishi ◽

...

Keyword(s):

Case Report ◽

Adrenal Gland ◽

Neuroendocrine Carcinoma ◽

The Right

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Primary adrenal sarcomatoid carcinoma

Clinics and Practice ◽

10.4081/cp.2014.604 ◽

2014 ◽

Vol 4 (1) ◽

Cited By ~ 5

Author(s):

Aftab S. Shaikh ◽

Girish D. Bakhshi ◽

Arshad S. Khan ◽

Nilofar M. Jamadar ◽

Aravind Kotresh Nirmala ◽

...

Keyword(s):

Computed Tomography ◽

Case Report ◽

Adrenal Gland ◽

Adrenal Mass ◽

Sarcomatoid Carcinoma ◽

Review Of Literature ◽

Rare Tumors ◽

Radiological Evidence ◽

The Right

Adrenal sarcomatoid carcinomas are extremely rare tumors presenting with extensive locoregional spread at the time of diagnosis. Patients succumb to metastases within a couple of months. As a result, very few cases are reported in the literature until now. We present a case of a 62-year old female with non-functional sarcomatoid carcinoma of the right adrenal gland. There was no radiological evidence of locoregional metastases. Patient underwent right adrenalectomy. Follow up after 3 months showed para-aortic lymphadenopathy and similar left adrenal mass on computed tomography. Patient refused further treatment and succumbed to the disease. A brief case report with review of literature is presented.

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Case Report: Malignant Pheochromocytoma Without Hypertension Accompanied by Increment of Serum VEGF Level and Catecholamine Cardiomyopathy

Frontiers in Endocrinology ◽

10.3389/fendo.2021.688536 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hideaki Kaneto ◽

Shinji Kamei ◽

Fuminori Tatsumi ◽

Masashi Shimoda ◽

Tomohiko Kimura ◽

...

Keyword(s):

Case Report ◽

Adrenal Gland ◽

Tumor Resection ◽

Left Ventricular ◽

Malignant Pheochromocytoma ◽

Left Ventricular Ejection ◽

Normal Range ◽

Ventricular Ejection Fraction ◽

The Right ◽

Vegf Level

IntroductionPheochromocytoma is a catecholamine-producing tumor in the adrenal medulla and is often accompanied by hypertension, hyperglycemia, hypermetabolism, headache, and hyperhidrosis, and it is classified as benign and malignant pheochromocytoma. In addition, persistent hypertension is often observed in subjects with malignant pheochromocytoma.Case PresentationA 52-year-old Japanese male was referred and hospitalized in our institution. He had a health check every year and no abnormalities had been pointed out. In addition, he had no past history of hypertension. In endocrinology markers, noradrenaline level was as high as 7,693 pg/ml, whereas adrenaline level was within normal range. Abdominal contrast-enhanced computed tomography revealed a 50-mm hyper-vascularized tumor with calcification in the right adrenal gland and multiple hyper-vascularized tumors in the liver. In 131I MIBG scintigraphy, there was high accumulation in the right adrenal gland and multiple accumulation in the liver and bone. In echocardiography, left ventricular ejection fraction was as low as 14.3%. In coronary angiography, however, there was no significant stenosis in the coronary arteries. Based on these findings, we finally diagnosed him as malignant pheochromocytoma accompanied by multiple liver and bone metastases and catecholamine cardiomyopathy. However, blood pressure was continuously within normal range without any anti-hypertensive drugs. Right adrenal tumor resection was performed together with left hepatic lobectomy and cholecystectomy. Furthermore, serum levels of vascular endothelial growth factor (VEGF) and parathyroid (PTH)-related protein were very high before the operation but they were markedly reduced after the operation.ConclusionsThis is the first report showing the time course of serum VEGF level in a subject with malignant pheochromocytoma, clearly showing that malignant pheochromocytoma actually secreted VEGF. In addition, this case report clearly shows that we should bear in mind once again that malignant pheochromocytoma is not necessarily accompanied by hypertension.

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Laparoscopic resection of a huge mature cystic teratoma of the right adrenal gland through retroperitoneal approach: a case report and literature review

World Journal of Surgical Oncology ◽

10.1186/s12957-015-0734-z ◽

2015 ◽

Vol 13 (1) ◽

Cited By ~ 8

Author(s):

Hengping Li ◽

Tao Zhao ◽

Qiang Wei ◽

Haichao Yuan ◽

Dehong Cao ◽

...

Keyword(s):

Case Report ◽

Literature Review ◽

Adrenal Gland ◽

Laparoscopic Resection ◽

Cystic Teratoma ◽

Mature Cystic Teratoma ◽

Retroperitoneal Approach ◽

The Right

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VERGLEICHENDE UNTERSUCHUNGEN ZUR BIOGENESE VON STEROIDHORMONEN BEI DURCHSTRÖMUNG ÜBERLEBENDER NEBENNIEREN EINER PATIENTIN MIT CUSHING- UND EINER PATIENTIN MIT CONN-SYNDROM

Acta Endocrinologica ◽

10.1530/acta.0.0430419 ◽

1963 ◽

Vol 43 (3) ◽

pp. 419-429 ◽

Cited By ~ 1

Author(s):

H. Schriefers ◽

J. M. Bayer ◽

M. Pittel

Keyword(s):

Adrenal Gland ◽

Adrenal Cortex ◽

Zona Glomerulosa ◽

Secretion Rate ◽

Zona Fasciculata ◽

Conn’S Syndrome ◽

Adrenal Cortical Adenoma ◽

Aldosterone Production ◽

The Right

ABSTRACT In vitro perfusion experiments were carried out with adrenal glands surgically removed from a patient with Cushing's syndrome (hyperplasia of the adrenal cortex) and a patient with Conn's syndrome (adrenal cortical adenoma). From the perfusates the following steroids were extracted, estimated and identified: cortisol, corticosterone, 11β-hydroxyandrostenedione, cortisone and aldosterone. The secretion capacities of the right Cushing adrenal and of the adrenal gland bearing the adenoma were compared with each other. In both adrenals cortisol was the main secretion product and the secretion rates of aldosterone were lowest and practically equal. The Cushing adrenal differed from the adrenal gland with the adenoma in its higher secretion rate of all investigated steroids except aldosterone, in its higher cortisol/aldosterone ratio and in its response to the administration of ACTH. To this stimulus the aldosterone production of the Cushing adrenal reacted in the same rate as the cortisol release. The adrenal gland with the adenoma of the patient with Conn's syndrome had only a relatively higher aldosterone secretion rate in respect to its lower cortisol production (lower cortisol/aldosterone ratio). The total preparation consisting of the adrenal with the adenoma responded neither to ACTH nor to hypertensin. The missing response of the adrenal cortex not including the tumor to ACTH is explained by the structural change in the sense of the so called regressive transformation (small zona fasciculata with relative large zona glomerulosa and reticularis) which was found in our case. Dehydroepiandrosterone was demonstrable in none of the perfusate extracts even under the condition where the left adrenal of the Cushing patient was perfused with added 17α-hydroxy-pregnenolone.

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