Incidence of Cochlear Involvement in Hyperbilirubinemic Deafness

Neonatal hyperbilirubinemia remains an important cause of childhood deafness, especially in developing countries. After neonatal hyperbilirubinemia, the auditory neural pathways, cochlea, or both may be affected. In this study, we aimed to determine the incidence of cochlear impairment and the appropriate means of hearing screening in hyperbilirubinemic neonates. A retrospective review of 1,032 pediatric patients with hearing loss revealed 67 cases (6.5%) of severe hyperbilirubinemia in the neonatal period. Thirty of these patients had neonatal hyperbilirubinemia as the single identifiable risk factor for hearing loss. In 26 of 30 cases (87%), otoacoustic emissions (OAEs) were absent, whereas in the remaining 4 cases (13%), robust emissions were detected despite an absent auditory brain stem response (ABR). Auditory screening of newborns with jaundice by OAEs possesses a significant risk of undiagnosed deafness. On the other hand, if the ABR is used as the single means of screening, auditory neuropathic conditions will probably be underlooked. Therefore, we recommend dual screening of hearing by ABR and OAEs in hyperbilirubinemic newborns.

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Changes in Otoacoustic Emissions and Auditory Brain Stem Response after C/s-Platinum Exposure in Gerbils

Otolaryngology ◽

10.1016/s0194-5998(97)70232-8 ◽

1997 ◽

Vol 116 (6) ◽

pp. 585-592 ◽

Cited By ~ 15

Author(s):

Kathleen C. Y. Sie ◽

Susan J. Norton

Keyword(s):

Hearing Loss ◽

Brain Stem ◽

Otoacoustic Emissions ◽

Outer Hair Cell ◽

Outer Hair Cells ◽

Distortion Product Otoacoustic Emissions ◽

Auditory Brain Stem Response ◽

Distortion Product ◽

Auditory Brain Stem ◽

Significant Difference

Ototoxicity associated with cis-platinum administration commonly presents as hearing loss and tinnitus. The hearing loss is usually an irreversible, high-frequency sensorineural loss. Histologic studies in humans and animals suggest that the outer hair cells (OHCs) are most susceptible to cis-platinum. Evoked otoacoustic emissions (EOAE), as a measure of outer hair cell function, are potentially useful in following ototoxic insults involving OHCs. Distortion-product otoacoustic emissions (DPOAE) test frequency-specific regions of the cochlea and therefore may be particularly well suited for monitoring ototoxic injuries. We measured distortion product otoacoustic emissions, at f2 = 2, 4, 6, 8, 10, and 12 kHz, in gerbils after a single large dose of cis-platinum. Animals treated with saline served as controls. The findings were compared to auditory brain stem evoked response (ABR) thresholds, using tone pips of the same frequencies. The DPOAE and ABR thresholds were measured before treatment and again 2, 5, and 14 days after drug administration. The changes in DPOAE were compared with the changes in ABR. No treatment effect was noted in the 2-day group. Animals treated with c/s-platinum demonstrated significant elevation of DPOAE and ABR thresholds compared with control animals at 5 and 14 days. There was no significant difference between the threshold changes in the 5-and 14-day groups.

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Newborn hearing screening

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh0706264b ◽

2007 ◽

Vol 135 (5-6) ◽

pp. 264-268 ◽

Cited By ~ 1

Author(s):

Snezana Babac ◽

Dragoslava Djeric ◽

Zoran Ivankovic

Keyword(s):

Hearing Loss ◽

Sensorineural Hearing Loss ◽

Brain Stem ◽

Otoacoustic Emissions ◽

Hearing Screening ◽

Newborn Hearing Screening ◽

Auditory Brain Stem Response ◽

Auditory Brain Stem ◽

Newborn Hearing ◽

Brain Stem Response

Introduction: Prevalence of sensorineural hearing loss is 1-3 per 1,000 newborns. Transient evoked otoacoustic emission (TEOAE) and automated auditory brain stem responses (AABR) are most frequently used methods in newborn hearing screening programmes. Objective. The aim of this study was to examine hearing function in newborns with and without risk factors for hearing loss. We investigated accuracy and feasibility of two automated technologies: transient otoacoustic emissions (TEOAE) and auditory brain stem response (AABR) in early detection of hearing loss. Method. In prospective study, 907 newborns were tested on both ears with transient evoked otoacoustic emissions (TEOAE). If results were "refer", we performed automated brain stem response (AABR). Two stage screening protocols were used with two screening technologies (TEOAE, AABR). Results. Results showed screening pass of 86.3% of the newborns in the first protocol and 99.3% in the second. Six (0.7%) newborns had positive screening results for hearing loss. They were referred for additional audolologic tests (otoacoustic emissions, tympanometry, and auditory brain stem response) to confirm or exclude hearing loss. Audiologic examination was performed up to the third month of life. We confirmed unilateral sensorineural hearing loss in two babies. Average test time per ear was 21.3?19.4 s for TEOAE and 135.3?67.9 s for AABR. Conclusion TEOAE, AABR tests are confidential, noninvasive and feasible methods and can help to detect hearing impairment.

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The Auditory Brain Stem Response Reliably Predicts Hearing Loss in Graduates of a Tertiary Intensive Care Nursery

Ear and Hearing ◽

10.1097/00003446-198407000-00011 ◽

1984 ◽

Vol 5 (4) ◽

pp. 254-260 ◽

Cited By ~ 50

Author(s):

Robert Galambos ◽

Gayle E. Hicks ◽

Mary Jo Wilson

Keyword(s):

Hearing Loss ◽

Intensive Care ◽

Brain Stem ◽

Auditory Brain Stem Response ◽

Auditory Brain Stem ◽

Intensive Care Nursery ◽

Brain Stem Response

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Audiological findings following head trauma

The Journal of Laryngology & Otology ◽

10.1017/s0022215100114410 ◽

1990 ◽

Vol 104 (12) ◽

pp. 927-936 ◽

Cited By ~ 16

Author(s):

M. R. Abd Al-Hady ◽

O. Shehata ◽

M. El-Mously ◽

F. S. Sallam

Keyword(s):

Hearing Loss ◽

Head Injury ◽

Head Trauma ◽

Repetition Rate ◽

Control Group ◽

Traumatic Head Injury ◽

Auditory Brain Stem Response ◽

Auditory Brain Stem ◽

Significant Difference ◽

Traumatic Head

AbstractTraumatic head injury is the principal cause of death and serious physical disability in adolescents and young adult. Hearing loss is a common sequela of head trauma. The results of pure tone and auditory brain-stem response (ABR) assessment of minor head injury revealed that 20 per cent of these cases showed impairment of hearing including both conductive and sensorineural heaing loss mostly in the high frequencies loss.ABR findings showed a significant difference of absolute wave V latency and interwave (III-V) latencies at repetition rate 11.1 click/sec., and a highly significant difference at a repetition rate of 51.1 click/sec., compared with the control group.In severe head injury, conductive hearing loss was found in only one case, in which a longitudinal fracture of the temporal bone was identified radiologically. No ABR could be recorded at a repetition rate of 11.1 click/sec. in either ear of this case; this patient died a few days later.Three cases were found with a mixed sensorineural hearing loss; one of them showed a longitudinal fracture radiologically. ABR findings in two cases showed prolongation of wave V and I–V interwave latencies, and the third case showed absence of ABR recording.In comatose patients, an ABR grading system is a more sensitive index of brainstem dysfunction than the simple division of normal versus abnormal ABR waves and interwave latencies. Presence or prolongation of wave V and interwave latency I–V even in one ear is of good prognostic value in the comatosed patient.

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Interaction of Click Intensity and Cochlear Hearing Loss on Auditory Brain Stem Response Wave V Latency

Ear and Hearing ◽

10.1097/00003446-199202000-00007 ◽

1992 ◽

Vol 13 (1) ◽

pp. 28-34 ◽

Cited By ~ 7

Author(s):

Peggy Oates ◽

David R. Stapells

Keyword(s):

Hearing Loss ◽

Brain Stem ◽

Auditory Brain Stem Response ◽

Auditory Brain Stem ◽

Cochlear Hearing Loss ◽

Brain Stem Response

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Electrical Stimulation of the Auditory Nerve via Cochlear Implants in Patients with Auditory Neuropathy

Annals of Otology Rhinology & Laryngology ◽

10.1177/00034894021110s506 ◽

2002 ◽

Vol 111 (5_suppl) ◽

pp. 29-31 ◽

Cited By ~ 21

Author(s):

Yvonne S. Sininger ◽

Patricia Trautwein

Keyword(s):

Electrical Stimulation ◽

Cochlear Implants ◽

Auditory Nerve ◽

Otoacoustic Emissions ◽

Outer Hair Cell ◽

Cell Function ◽

Auditory Neuropathy ◽

Auditory Brain Stem Response ◽

Average Performance ◽

Auditory Brain Stem

Auditory neuropathy (AN) is a term used to describe an auditory disorder in which there is evidence of normal outer hair cell function (otoacoustic emissions and/or cochlear microphonics) and poor function of the auditory nerve (absent or highly distorted auditory brain stem response starting with wave I). Many of these patients have evidence of generalized peripheral nerve disease, leading to an assumption that the peripheral portion of the auditory nerve is the most likely site of lesion. A small group of these patients has received cochlear implants, and the majority of them achieve average to above-average performance. Although this outcome may seem incongruous with neural disease, average performance by patients with AN may be a result of the reintroduction of neural synchrony by electrical stimulation and/or the fact that most deaf patients have poor nerve survival. Although cochlear implants are promising for deaf patients with AN, more study of the disorder is needed.

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