Laser Resection for Early Oral Cavity Cancer

1987 ◽  
Vol 96 (5) ◽  
pp. 556-560 ◽  
Author(s):  
Matthew J. Nagorsky ◽  
Donald G. Sessions
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Complication Rate ◽  
Oral Cavity Cancer ◽  
Local Control Rate ◽  
Tumor Control ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Laser Excision ◽  
High Level

Laser excision of early selected cancers of the oral cavity and pharynx is a well accepted and reported treatment. Postoperative radiation therapy is employed in patients with unfavorable pathologic findings and in patients expected to have a high recurrence and metastatic rate. In most patients the combination of laser excision and postoperative radiation therapy is well tolerated and results in satisfactory healing, excellent tumor control, and high-level posttreatment function. This report discusses the treatment and results in 28 patients treated for early cancer of the oral cavity and pharynx. The local control rate of 77% compares favorably with the reported results following either conventional or laser excision of these lesions. The overall complication rate was 39%, with a 25% rate for patients not receiving postoperative radiation therapy, and a 58% complication rate for patients treated with postoperative radiation.

scholarly journals Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III

Head & Neck ◽  
2019 ◽  
Vol 41 (5) ◽  
pp. 1178-1183 ◽  
Author(s):  
John D. Cramer ◽  
Sandeep Samant ◽  
Dwight E. Heron ◽  
Robert L. Ferris ◽  
Seugwon Kim
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Stage Iii ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy

Postoperative Radiation Therapy in Oral Cavity Verrucous Carcinoma

2022 ◽  
Author(s):  
Akash N. Naik ◽  
Dustin A. Silverman ◽  
Chandler J. Rygalski ◽  
Songzhu Zhao ◽  
Guy Brock ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Verrucous Carcinoma ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy

Value of Radiation Therapy in Addition to Surgery for Cancer of the Head and Neck

1986 ◽  
Vol 94 (5) ◽  
pp. 601-604 ◽  
Author(s):  
Ahmad Sadeghi ◽  
John McLaren ◽  
William L. Grist ◽  
Luu Tran ◽  
Hans Kuisk
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Head And Neck ◽  
Primary Site ◽  
Surgical Margins ◽  
Controlled Study ◽  
Tumor Control ◽  
Postoperative Radiation Therapy ◽  
Treatment Groups ◽  
Nodal Control

This historically controlled study evaluates radiation therapy in 119 patients—With squamous cell carcinomas of the head and neck—who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and nodal control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rate in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.

Stage II Oral Tongue Cancer: Survival Impact of Adjuvant Radiation Based on Depth of Invasion

2018 ◽  
Vol 160 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Samuel J. Rubin ◽  
Ellen B. Gurary ◽  
Muhammad M. Qureshi ◽  
Andrew R. Salama ◽  
Waleed H. Ezzat ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Oral Cavity ◽  
Tongue Cancer ◽  
Univariate Analysis ◽  
Adjuvant Radiation ◽  
Depth Of Invasion ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Significant Difference

Objective To determine if adjuvant radiation therapy for patients with pT2N0 oral cavity tongue cancer affects overall survival. Study Design Retrospective cohort study. Setting National Cancer Database. Subjects and Methods Cases diagnosed between 2004 and 2013 with pathologic stage pT2N0 oral cavity tongue cancer with negative surgical margins were extracted from the National Cancer Database. Data were stratified by treatment received, including surgery only and surgery + postoperative radiation therapy. Univariate analysis was performed with a 2-sample t test, chi-square test, or Fisher exact test and log-rank test, while multivariate analysis was performed with Cox regression models adjusted for individual variables as well as a propensity score. Results A total of 934 patients were included in the study, with 27.5% of patients receiving surgery with postoperative radiation therapy (n = 257). In univariate analysis, there was no significant difference in 3-year overall survival between the patient groups ( P = .473). In multivariate analysis, there was no significant difference in survival between the treatment groups, with adjuvant radiation therapy having a hazard ratio of 0.93 (95% CI, 0.60-1.44; P = .748). Regarding tumors with a depth of invasion >5 mm, there was no survival benefit for the patients who received postoperative radiation therapy as compared with those who received surgery alone (hazard ratio = 0.93; 95% CI, 0.57-1.53; P = .769). Conclusion An overall survival benefit was not demonstrated for patients who received postoperative radiation therapy versus surgery alone for pT2N0 oral cavity tongue cancer, irrespective of depth of tumor invasion.

Value of Radiation Therapy in Addition to Surgery for Cancer of the Head and Neck

1986 ◽  
Vol 94 (6) ◽  
pp. 601-604 ◽  
Author(s):  
Ahmad Sadeghi ◽  
John Mclaren ◽  
William L. Grist ◽  
Luu Tran ◽  
Hans Kuisk
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Head And Neck ◽  
Primary Site ◽  
Surgical Margins ◽  
Controlled Study ◽  
Tumor Control ◽  
Postoperative Radiation Therapy ◽  
Treatment Groups ◽  
Nodal Control

This historically controlled study evaluates radiation therapy in 119 patients—with squamous cell carcinomas of the head and neck—who underwent surgery alone (SA) or surgery plus radiation (S + R). The primary tumor control and nodal control, in patients with negative surgical margins who had surgery alone (SA), were 63% in the oral cavity, 60% in the oropharynx, and 67% in the hypopharynx. The same rates for S + R group and negative surgical margins were 100%, 73%, and 100%. Combining the patients with negative and positive surgical margins, control of the tumor and noddl control were the same in the oral cavity for both treatment groups (41% for SA and 44% for S + R) and increased with the addition of radiation in the oropharynx (30% for SA to 65% for S + R) and hypopharynx (33% for SA to 86% for S + R), in spite of higher percentages of T3 and T4 tumor and positive lymph nodes in the S + R group. The lower control rote in patients who had surgery alone could be due (in part) to inadequate surgery at the primary site (42% local excision) and lack of neck dissection (35% for SA vs. 77% for S + R). Postoperative radiation therapy to the primary site and neck is shown to effectively reduce local recurrence in patients with oral cavity and oropharynx cancer, regardless of surgical margins.

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