scholarly journals Impact of postoperative radiation therapy for deeply invasive oral cavity cancer upstaged to stage III

Head & Neck ◽  
2019 ◽  
Vol 41 (5) ◽  
pp. 1178-1183 ◽  
Author(s):  
John D. Cramer ◽  
Sandeep Samant ◽  
Dwight E. Heron ◽  
Robert L. Ferris ◽  
Seugwon Kim
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Oral Cavity Cancer ◽  
Stage Iii ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy

Laser Resection for Early Oral Cavity Cancer

1987 ◽  
Vol 96 (5) ◽  
pp. 556-560 ◽  
Author(s):  
Matthew J. Nagorsky ◽  
Donald G. Sessions
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Complication Rate ◽  
Oral Cavity Cancer ◽  
Local Control Rate ◽  
Tumor Control ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Laser Excision ◽  
High Level

Laser excision of early selected cancers of the oral cavity and pharynx is a well accepted and reported treatment. Postoperative radiation therapy is employed in patients with unfavorable pathologic findings and in patients expected to have a high recurrence and metastatic rate. In most patients the combination of laser excision and postoperative radiation therapy is well tolerated and results in satisfactory healing, excellent tumor control, and high-level posttreatment function. This report discusses the treatment and results in 28 patients treated for early cancer of the oral cavity and pharynx. The local control rate of 77% compares favorably with the reported results following either conventional or laser excision of these lesions. The overall complication rate was 39%, with a 25% rate for patients not receiving postoperative radiation therapy, and a 58% complication rate for patients treated with postoperative radiation.

Postoperative Radiation Therapy in Oral Cavity Verrucous Carcinoma

2022 ◽  
Author(s):  
Akash N. Naik ◽  
Dustin A. Silverman ◽  
Chandler J. Rygalski ◽  
Songzhu Zhao ◽  
Guy Brock ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oral Cavity ◽  
Verrucous Carcinoma ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy

Stage II Oral Tongue Cancer: Survival Impact of Adjuvant Radiation Based on Depth of Invasion

2018 ◽  
Vol 160 (1) ◽  
pp. 77-84 ◽  
Author(s):  
Samuel J. Rubin ◽  
Ellen B. Gurary ◽  
Muhammad M. Qureshi ◽  
Andrew R. Salama ◽  
Waleed H. Ezzat ◽  
...  
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Oral Cavity ◽  
Tongue Cancer ◽  
Univariate Analysis ◽  
Adjuvant Radiation ◽  
Depth Of Invasion ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Significant Difference

Objective To determine if adjuvant radiation therapy for patients with pT2N0 oral cavity tongue cancer affects overall survival. Study Design Retrospective cohort study. Setting National Cancer Database. Subjects and Methods Cases diagnosed between 2004 and 2013 with pathologic stage pT2N0 oral cavity tongue cancer with negative surgical margins were extracted from the National Cancer Database. Data were stratified by treatment received, including surgery only and surgery + postoperative radiation therapy. Univariate analysis was performed with a 2-sample t test, chi-square test, or Fisher exact test and log-rank test, while multivariate analysis was performed with Cox regression models adjusted for individual variables as well as a propensity score. Results A total of 934 patients were included in the study, with 27.5% of patients receiving surgery with postoperative radiation therapy (n = 257). In univariate analysis, there was no significant difference in 3-year overall survival between the patient groups ( P = .473). In multivariate analysis, there was no significant difference in survival between the treatment groups, with adjuvant radiation therapy having a hazard ratio of 0.93 (95% CI, 0.60-1.44; P = .748). Regarding tumors with a depth of invasion >5 mm, there was no survival benefit for the patients who received postoperative radiation therapy as compared with those who received surgery alone (hazard ratio = 0.93; 95% CI, 0.57-1.53; P = .769). Conclusion An overall survival benefit was not demonstrated for patients who received postoperative radiation therapy versus surgery alone for pT2N0 oral cavity tongue cancer, irrespective of depth of tumor invasion.

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