Chronic Perilymph Fistula in the Guinea Pig with Implications in the Human

To improve understanding of the pathophysiology of perilymph fistulas, a predictable animal model of a chronic fistula was developed. Our findings suggest that guinea pig fistulas do not remain patent for prolonged periods. By extrapolating these findings to humans, we postulate that the symptoms and signs of perilymph fistula are possibly due not to one prolonged constant fistula, but rather a series of “blowouts” from an inherent congenital or posttraumatic weak spot in either the round or oval window. We feel that a diagnosis of perilymph fistula must be considered in any patient presenting with a Meniere's-like symptom set concomitant with a congenital inner ear deformity or a history of inner ear trauma.

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Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

Clinical and Experimental Otorhinolaryngology ◽

10.21053/ceo.2019.00766 ◽

2020 ◽

Vol 13 (2) ◽

pp. 106-112 ◽

Cited By ~ 1

Author(s):

Se-Joon Oh ◽

Il-Woo Lee ◽

Soo-Geun Wang ◽

Soo-Keun Kong ◽

Hong-Ki Kim ◽

...

Keyword(s):

Animal Model ◽

Optical Coherence Tomography ◽

Inner Ear ◽

Oval Window ◽

Diagnostic Information ◽

Optical Coherence ◽

Swept Source ◽

Diagnostic Technology ◽

Swept Source Oct ◽

Rats And Mice

Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea.Conclusion. OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

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Otosurgical Model in the Guinea Pig (Cavia porcellus)

Otolaryngology ◽

10.1177/019459988609500406 ◽

1986 ◽

Vol 95 (4) ◽

pp. 450-457 ◽

Cited By ~ 15

Author(s):

James R. Wells ◽

William H. Gernon ◽

George Warp ◽

R. Kim Davis ◽

Leonard L. Hays

Keyword(s):

Animal Model ◽

Guinea Pig ◽

Inner Ear ◽

Middle Ear ◽

Surgical Anatomy ◽

Cavia Porcellus ◽

Middle Ear Disease ◽

Common Problems ◽

Lack Of Knowledge

The guinea pig is a useful model for otologic research. Common problems encountered In working with Individual animals include preexisting chronic middle ear disease, anesthetic deaths, and a lack of knowledge of the surgical anatomy and landmarks of the middle and inner ear. The methods detailed in this article will benefit those interested In a reliable, inexpensive, otosurgical animal model.

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Effect of Aspiration of Perilymph during Stapes Surgery on the Endocochlear Potential of Guinea Pig

Otolaryngology ◽

10.1177/0194599811409516 ◽

2011 ◽

Vol 145 (5) ◽

pp. 801-805 ◽

Cited By ~ 13

Author(s):

Ryoukichi Ikeda ◽

Kazuhiro Nakaya ◽

Hidetoshi Oshima ◽

Takeshi Oshima ◽

Tetsuaki Kawase ◽

...

Keyword(s):

Hearing Loss ◽

Guinea Pig ◽

Inner Ear ◽

Oval Window ◽

Stapes Surgery ◽

Partial Recovery ◽

Cochlear Function ◽

Stapes Footplate ◽

Guinea Pig Model ◽

Temporal Bones

Objective. Suction applied to the vestibule through the oval window during stapes surgery is considered a primary risk for postoperative sensorineural hearing impairment. This study investigated the mechanism of acute phase change in cochlear function caused by aspiration of the opened oval window. Study Design. Guinea pig model. Setting. Academic hospital laboratory. Subjects and Methods. Guinea pigs were divided into 3 groups: stapes footplate removed without suctioning (6 animals), with indirect suctioning (5 animals), and with direct suctioning of the vestibular perilymph (6 animals). Endocochlear potentials (EPs) were measured at the second turn of the cochlea, and temporal bones were examined histologically. Results. Removal of the stapes footplate without suctioning caused little change in the EP (original value, 80.12 ± 3.52 mV), indirect suctioning caused minor decline of the EP of 9.14 ± 1.84 mV, and partial recovery ensued, whereas direct but gentle suctioning, resulting in dry vestibule, caused reduction in the EP of 16.38 ± 6.63 mV. Recovery was not observed or incomplete. No animals showed profound decrease in the EP. Conclusion. Gentle suctioning and removal of the vestibular perilymph can cause a mild decrease in the EP even without damaging the inner ear structures. Therefore, suctioning of the perilymph should be avoided during stapes surgery because acute hearing loss can result even without damaging the inner ear structures. However, hearing loss may not be profound, if suctioning is not vigorous enough to cause damage to the inner ear structures.

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The Abnormality of Vestibular Hair Cells and the Gene Transduction in Animal Model of Human Genetic Inner Ear Disease-Study of Vestibular Hair Cell Pathology in Shaker-2 Mouse and Waltzing Guinea Pig-

Equilibrium Research ◽

10.3757/jser.63.81 ◽

2004 ◽

Vol 63 (2) ◽

pp. 81-88

Author(s):

Sho Kanzaki

Keyword(s):

Animal Model ◽

Guinea Pig ◽

Hair Cell ◽

Inner Ear ◽

Hair Cells ◽

Gene Transduction ◽

Vestibular Hair Cells ◽

Inner Ear Disease ◽

Disease Study

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Hair Cell Damage in the Inner Ear of the Guinea Pig Due to Noise in a Workshop

Acta Oto-Laryngologica ◽

10.3109/00016488709107785 ◽

1987 ◽

Vol 103 (5) ◽

pp. 204-211 ◽

Cited By ~ 3

Author(s):

B. Erlandsson ◽

H. Hakanson ◽

A. Ivarsson ◽

P. Nilsson ◽

J. Wersall

Keyword(s):

Guinea Pig ◽

Hair Cell ◽

Inner Ear ◽

Cell Damage ◽

Hair Cell Damage

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When less is more: a daring conservative approach to postpneumonectomy oesophago-pleural fistula

Interactive CardioVascular and Thoracic Surgery ◽

10.1093/icvts/ivz240 ◽

2019 ◽

Vol 30 (1) ◽

pp. 146-148

Author(s):

Lara Girelli ◽

Elena Prisciandaro ◽

Niccolò Filippi ◽

Lorenzo Spaggiari

Keyword(s):

Clinical Presentation ◽

Clinical Status ◽

High Morbidity ◽

Conservative Approach ◽

Chronic Fistula ◽

Less Is More ◽

Primary Surgery ◽

History Of ◽

Uncommon Complication

Abstract Oesophago-pleural fistula is an uncommon complication after pneumonectomy, usually related to high morbidity and mortality. Due to its rarity and heterogeneous clinical presentation, its diagnosis and management are challenging issues. Here, we report the case of a patient with a history of pneumonectomy for a tracheal tumour, who developed an asymptomatic oesophago-pleural fistula 7 years after primary surgery. In consideration of the patient’s good clinical status and after verifying the preservation of respiratory and digestive functions, a bold conservative approach was adopted. Five-year follow-up computed tomography did not disclose any sign of recurrence of disease and showed a stable, chronic fistula.

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Lipopolysaccharide decreases cochlear blood flow dose dependently in a guinea pig animal model via TNF signaling

Microcirculation ◽

10.1111/micc.12681 ◽

2021 ◽

Author(s):

Friedrich Ihler ◽

Saskia Freytag ◽

Benedikt Kloos ◽

Jennifer Lee Spiegel ◽

Frank Haubner ◽

...

Keyword(s):

Animal Model ◽

Blood Flow ◽

Guinea Pig ◽

Cochlear Blood Flow ◽

Pig Animal Model

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Hereditary haemorrhagic telangiectasia: A case report

SAGE Open Medical Case Reports ◽

10.1177/2050313x211003076 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110030

Author(s):

Asfandyar Mufti ◽

Muskaan Sachdeva ◽

Khalad Maliyar ◽

Marissa Joseph

Keyword(s):

Arteriovenous Malformations ◽

Genetic Disorder ◽

Clinical Manifestations ◽

Hereditary Haemorrhagic Telangiectasia ◽

Lower Lip ◽

Recurrent Epistaxis ◽

Receptor Like Kinase ◽

History Of ◽

The Right ◽

Symptoms And Signs

Background: Hereditary haemorrhagic telangiectasia is an autosomal dominant genetic disorder characterized by abnormalities in blood vessel formation. The clinical manifestations of patients affected with hereditary haemorrhagic telangiectasia include mucocutaneous telangiectasias and visceral arteriovenous malformations. Case Summary: We report the case of a 30-year-old female diagnosed with hereditary haemorrhagic telangiectasia presenting with the classic triad of recurrent epistaxis, mucocutaneous telangiectasias and family history of hereditary haemorrhagic telangiectasia with activin receptor-like kinase 1 mutation. Upon skin examination, she was noted to have telangiectasias under left naris, inner lower lip and surface of the tongue, and a vascular malformation on the right forearm. Conclusion: Although the skin involvement and epistaxis may be mild symptoms and signs of hereditary haemorrhagic telangiectasia, timely recognition of these can ensure vigilant monitoring of potential severe complications from cerebral and pulmonary visceral arteriovenous malformations.

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