Uplink Spectrum Overlay Coverage Enhancement Algorithm in 5G Network

The imbalance between the uplink and downlink rates and coverage of the 5G network has led to limited vertical industry services. Aiming at breaking the imbalance between the uplink and downlink rates and improving the coverage of 5G network, a uplink coverage enhancement algorithm is designed from the aspects of networking mode, bandwidth, uplink and downlink subframe ratio, etc. It uses high- and low-frequency time-frequency joint scheduling to enable uplink full-time slot scheduling, thereby improving uplink coverage and rate. According to the actual test on the live network, the results show that the super-uplink algorithm can increase the near-point uplink rate by 15% to 30%, increase the uplink rate for indoor midpoint scenarios by 40% to 80%, and increase the uplink rate for outdoor and indoor weak spot scenarios by 100% to 400%.

EP.TH.96Recurrent Retroperitoneal Liposarcoma Presenting as Irreducible Inguinal Hernia

Introduction Retroperitoneal sarcomas protruding though the groin are extremely rare with only about 12 cases reported in the past 31 years to our knowledge. . As the retroperitoneal space communicates with the inguinal canal, large lipomatous tumors, may protrude through this natural weak spot which may present as irreduciible inguinal hernia. Case Report We report a 43 year old male, previously operated for retroperitoneal liposarcoma with 4 cycles of adjuvant chemotherapy and 5 cycles of radiotherapy 4 years back now presented with irreducible inguinal hernia. On examination, a firm fixed mass of about 15 x 10 cm, with indistinct margins was palpable in right hemiabdomen, abdomen was soft with audible bowel sounds. A firm swelling of 8 x 5 cm in right inguinal region extending into scrotum with no cough impulse was also present. On CT imaging a large mixed density lesion noted in Right lower abdomen measuring 16.2 x 14.8 x 23.5 cm. It showed internal fat and solid components and recurrence with herniation through right inguinal canal which is a rare entity. The patient was treated symptomatically, bilateral DJ stenting was done by the urology team and the patient was prepared for debulking surgery. Patient was classified as ASA IV. Unfortunately, the patient died 6th post admission day secondary to cardiopulmonary arrest. Conclusion A retroperitoneal tumor especially a liposarcoma should be ruled out in a large, painless, non-reducible inguinal mass with abdominal complaints. Patients need regular follow up after resection of retroperitoneal liposarcoma for early detection of recurrence.

Interlayer Reinforcement Combined with Fiber Reinforcement for Extruded Lightweight Mortar Elements

Lightweight mortar extrusion enables the production of monolithic exterior wall components with improved thermal insulation by installing air chambers and reduced material demand compared to conventional construction techniques. However, without reinforcement, the systems are not capable of bearing high flexural forces and, thus, the application possibilities are limited. Furthermore, the layer bonding is a weak spot in the system. We investigate a reinforcement strategy combining fibers in the mortar matrix with vertically inserted elements to compensate the layer bonding. By implementing fibers in the extruded matrix, the flexural strength can be increased almost threefold parallel to the layers. However, there is still an anisotropy between the layers as fibers are oriented during deposition and the layer bond is still mainly depending on hydration processes. This can be compensated by the vertical insertion of reinforcement elements in the freshly deposited layers. Corrugated wire fibers as well as short steel reinforcement elements were suitable to increase the flexural strength between the layers. As shown, the potential increase in flexural strength could be of a factor six compared to the reference (12 N/mm2 instead of 1.9 N/mm2). Thus, the presented methods reduce anisotropy in flexural strength due to layered production.

Economy could be Hungarian government’s weak spot

Headline HUNGARY: Economy could be government’s weak spot

Shattering Populists’ Rhetoric with Satire at Elections Times: The Effect of Humorously Holding Populists Accountable for Their Lack of Solutions

The popularity of populist parties has increased worldwide, and disproportionate media attention for these parties arguably fueled their success. We empirically test our theoretical argument that political satire—with its humor, focus on internal contradictions, and lack of journalistic principles regarding objectivity and facticity—may be an effective antidote to populism’s success. Using a representative panel survey that functions as a natural experiment in the context of the Netherlands, we show that consumption of the satire show Zondag met Lubach (ZML) indeed lowered support for a right-wing populist party (PVV), its leader (Wilders), and the perceived capability of this party. Specifically, this study shows how satirically revealing the “weak spot” of populism (i.e., lacking concrete treatment recommendations) lowers populist support particularly among citizens already inclined to vote for populist parties. These findings have important democratic implications as they reveal that satire can have a real-life impact on the political decisions that voters make.

Russia will continue cautious covert action in Balkans

Subject Russian espionage in the Balkans. Significance Spy scandals have rocked Bulgaria in recent months and have already led to the expulsion of three Russian diplomats. Moscow sees South-eastern Europe as a weak spot in the Western alliance. Scrutinised by the West, the government in Sofia is under pressure to take a tougher stand on Moscow’s influence in the country. Impacts The new Bulgarian prosecutor general’s anti-graft campaign will exclude the energy sector, where Russia’s clout is extensive. It is the United States, not the EU, that will lead the pushback against Russian influence. The spy scandals are unlikely to cause irreparable damage to Russia’s interests in South-eastern Europe.

Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein

Graphical superimposed snapshots of the Thompson novel loop (yellow) of menG protein: apo (A) and bound (B) systems. The loop switches between open and closed conformations; critical for therapeutic activity.

Intrinsic Disorder-Based Design of Stable Globular Proteins

Directed stabilization of globular proteins via substitution of a minimal number of amino acid residues is one of the most complicated experimental tasks. This work summarizes our research on the effect of amino acid substitutions on the protein stability utilizing the outputs of the analysis of intrinsic disorder predisposition of target proteins. This allowed us to formulate the basis of one of the possible approaches to the stabilization of globular proteins. The idea is quite simple. To stabilize a protein as a whole, one needs to find its "weakest spot" and stabilize it, but the question is how this weak spot can be found in a query protein. Our approach is based on the utilization of the computational tools for the per-residue evaluation of intrinsic disorder predisposition to search for the "weakest spot" of a query protein (i.e., the region(s) with the highest local predisposition for intrinsic disorder). When such "weakest spot" is found, it can be stabilized through a limited number of point mutations by introducing order-promoting residues at hot spots, thereby increasing structural stability of a protein as a whole. Using this approach, we were able to obtain stable mutant forms of several globular proteins, such as Gαo, GFP, ribosome protein L1, and circular permutant of apical domain of GroEL.