scholarly journals Do other variables add value to assessment of the risk of colorectal disease using faecal immunochemical tests for haemoglobin?

2019 ◽  
Vol 56 (4) ◽  
pp. 472-479 ◽  
Author(s):  
Jayne Digby ◽  
Robert JC Steele ◽  
Judith A Strachan ◽  
Craig Mowat ◽  
Annie S Anderson ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
Odds Ratios ◽  
Lower Bowel ◽  
Bowel Symptoms ◽  
History Of ◽  
Inflammatory Bowel

Background Faecal immunochemical tests for haemoglobin have been recommended to assist in assessment of patients presenting in primary care with lower bowel symptoms. The aim was to assess if, and which, additional variables might enhance this use of faecal immunochemical tests. Methods Faecal immunochemical test analysis has been a NHS Tayside investigation since December 2015. During the first year, 993 patients attending colonoscopy were invited to complete a detailed questionnaire on demographic background, symptoms, smoking status, alcohol use, dietary fibre, red and processed meat intake, physical activity, sitting time, dietary supplement use, family history of colorectal cancer, adenoma, inflammatory bowel disease and diabetes. Significant bowel disease was classified as colorectal cancer, advanced adenoma or inflammatory bowel disease. Results A total of 470 (47.3%) invitees agreed to complete the questionnaire and 408 (41.1%) did. Unadjusted odds ratios for the presence of significant bowel disease compared with undetectable faecal haemoglobin increased with increasing faecal haemoglobin and for faecal haemoglobin 10–49, 50–199, 200–399 and ⩾400 μg Hb/g faeces were 0.95 (95% CI: 0.16–5.63), 2.47 (0.55–1.03), 6.30 (1.08–36.65) and 18.90 (4.22–84.62), respectively. Rectal bleeding and family history of polyps were the only other variables with statistically significant ( P < 0.05) odds ratios greater than 1.00, being 1.88 (1.13–3.17) and 2.93 (1.23–6.95), respectively. Odds ratios adjusted for all other variables showed similar associations, but only faecal haemoglobin and family history of polyps had significant associations. Conclusions Faecal haemoglobin is the most important factor to be considered when deciding which patients presenting in primary care with lower bowel symptoms would benefit most from referral for colonoscopy.

Mo1375 Prevalence of Family History of Inflammatory Bowel Disease Among Ulcerative Colitis Patients

2013 ◽  
Vol 144 (5) ◽  
pp. S-649-S-650
Author(s):  
Ryan E. Childers ◽  
Swathi Eluri ◽  
Christine Vazquez ◽  
Theodore M. Bayless ◽  
Susan Hutfless
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
History Of ◽  
Inflammatory Bowel

scholarly journals Crohn’s disease severity in familial and sporadic cases

Gut ◽  
1999 ◽  
Vol 44 (1) ◽  
pp. 91-95 ◽  
Author(s):  
F Carbonnel ◽  
G Macaigne ◽  
L Beaugerie ◽  
J P Gendre ◽  
J Cosnes
Keyword(s):  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Family History ◽  
Crohn's Disease ◽  
Disease Severity ◽  
Bowel Disease ◽  
History Of ◽  
Sporadic Cases ◽  
Inflammatory Bowel ◽  
Excisional Surgery

BackgroundHaving a relative with inflammatory bowel disease increases the risk for Crohn’s disease but may also increase its severity in affected patients.AimsTo evaluate the influence of a family history on Crohn’s disease course and severity.Methods1316 patients followed in the same unit were studied retrospectively. Age at onset, duration of illness, site, and extent of disease were determined in patients with and without a family history. Additionally, disease severity was estimated by the need for medical therapy (steroid and immunosuppressive requirement) and the frequency and extent of excisional surgery.Results152 (12%) patients had a family history of inflammatory bowel disease. Duration of follow up was longer in patients with a family history and there were more operations for perforating complications in familial cases. However, the importance of medical therapy, and the incidence and extent of excisional surgery were similar in familial and and sporadic cases. Kaplan-Meier estimated time to prescription of immunosuppressive drugs and first intestinal resection were similar in familial and sporadic cases. When the 152 patients with familial Crohn’s disease were paired for sex, location of disease at onset, date of birth, and date of diagnosis with 152 patients with sporadic Crohn’s disease, the disease severity remained similar in the two groups of paired patients.ConclusionPatients with Crohn’s disease and a family history of inflammatory bowel disease do not have a more severe course.

scholarly journals Granulomatous Inflammation Causing Severe Supraglottic Edema and Airway Obstruction in a Pediatric Patient

2020 ◽  
pp. 014556132097377
Author(s):  
Sophia M. Colevas ◽  
Bradley T. Gietman ◽  
Shelly M. Cook ◽  
Tony L. Kille
Keyword(s):  
Inflammatory Bowel Disease ◽  
Family History ◽  
Crohn Disease ◽  
Bowel Disease ◽  
Sleep Disordered Breathing ◽  
Granulomatous Inflammation ◽  
Laser Resurfacing ◽  
History Of ◽  
Inflammatory Bowel ◽  
Supraglottic Larynx

A 12-year-old male with a family history of inflammatory bowel disease presented with sleep-disordered breathing and was found to have chronic, granulomatous swelling of the supraglottic larynx. His airway was managed with tracheostomy, regular interval laryngeal steroid injections, supraglottoplasty, and “pepper pot” CO2 laser resurfacing leading to eventual decannulation. Due to the non-necrotic nature of the granulomatous inflammation, as well as the patient’s family history of inflammatory bowel disease, the leading diagnosis was Crohn disease, but isolated laryngeal sarcoidosis could not be ruled out. There are only 13 reported cases of laryngeal manifestations of Crohn disease in the literature, with only 2 cases occurring in pediatric patients. This case report adds to this body of literature and discusses strategies for managing granulomatous supraglottic edema when definitive diagnosis is not fully clear.

Family history as a risk factor for colorectal cancer in inflammatory bowel disease

2001 ◽  
Vol 120 (6) ◽  
pp. 1356-1362 ◽  
Author(s):  
Johan Askling ◽  
Paul W. Dickman ◽  
Anders Ekbom ◽  
Per Karlén ◽  
Olle Broström ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Disease ◽  
Risk Factor ◽  
Family History ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Colorectal cancer surveillance in inflammatory bowel disease: a primary care perspective

Gut ◽  
2011 ◽  
Vol 60 (Suppl 1) ◽  
pp. A130-A130
Author(s):  
E. A. Arthurs ◽  
K. Burley ◽  
B. Gholkar ◽  
L. Williams ◽  
M. Lockett
Keyword(s):  
Colorectal Cancer ◽  
Primary Care ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cancer Surveillance ◽  
Inflammatory Bowel ◽  
Colorectal Cancer Surveillance

DOES HAVING A FAMILY HISTORY OF INFLAMMATORY BOWEL DISEASE AFFECT QUALITY OF LIFE IN NEWLY DIAGNOSED CHILDREN?

2006 ◽  
Vol 43 (4) ◽  
pp. E48
Author(s):  
Abigail Garrity ◽  
Trudy Lerer ◽  
Anthony Otley ◽  
James Markowitz ◽  
Anne Griffiths ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
Newly Diagnosed ◽  
History Of ◽  
Inflammatory Bowel

scholarly journals Family history of inflammatory bowel disease among patients with ulcerative colitis: A systematic review and meta-analysis

2014 ◽  
Vol 8 (11) ◽  
pp. 1480-1497 ◽  
Author(s):  
Ryan E. Childers ◽  
Swathi Eluri ◽  
Christine Vazquez ◽  
Rayna Matsuno Weise ◽  
Theodore M. Bayless ◽  
...  
Keyword(s):  
Systematic Review ◽  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
Meta Analysis ◽  
History Of ◽  
Inflammatory Bowel

Family history of inflammatory bowel disease is uncommon among African Americans

2003 ◽  
Vol 124 (4) ◽  
pp. A212
Author(s):  
Suryakanth R. Gurudu ◽  
Layla Hejjafar ◽  
Pankaj Singh ◽  
Jeffry A. Katz
Keyword(s):  
Inflammatory Bowel Disease ◽  
Family History ◽  
African Americans ◽  
Bowel Disease ◽  
History Of ◽  
Inflammatory Bowel

scholarly journals Increasing Rate of a Positive Family History of Inflammatory Bowel Disease (IBD) in Pediatric IBD Patients

2021 ◽  
Author(s):  
Maya Ruban ◽  
Adam Slavick ◽  
Achiya Amir ◽  
Amir Ben-Tov ◽  
Hadar Moran-Lev ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Family History ◽  
Bowel Disease ◽  
Biologic Therapy ◽  
Positive Family History ◽  
Nutritional Therapy ◽  
Negative Family History ◽  
History Of ◽  
Inflammatory Bowel ◽  
Pediatric Ibd

Abstract The role of a positive family history in pediatric inflammatory bowel disease (IBD) in the era of biologic therapy has not been elucidated. We retrospectively reviewed the medical records of children with IBD and retrieved demographic and clinical characteristics, including the presence of a positive family history of IBD, IBD phenotype, disease course, and therapy. Overall, 325 children (age range at diagnosis 11-15 years) were included, of whom 82 (25.2%) had a positive family history. Children diagnosed during 2016-2020 had a higher frequency of positive family history compared to those diagnosed during 2010-2015 (31.8% versus 20.7%, respectively, p = 0.024). Children with a positive family history had a higher risk for a stricturing phenotype than those with a negative family history (11.3% versus 2.8%, respectively, p = 0.052). They more often received nutritional therapy (53.7% versus 36.6%, p = 0.007) and less often received corticosteroids (36.6% versus 52.7%, p = 0.012). More children with a negative family history needed intensification of biologic therapy (p = 0.041). Conclusion: The rate of a positive family history of IBD in the pediatric IBD population is increasing. A positive family history may have some impact upon IBD phenotype but none on IBD outcome.

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