A Rapid Procedure for the Simultaneous Estimation of the Anticonvulsant Drugs, Ethosuximide, Phenobarbitone, Phenytoin, and Carbamazepine in Serum Using High-Pressure Liquid Chromatography
1983 ◽
Vol 20
(1)
◽
pp. 37-40
◽
Keyword(s):
A rapid isocratic high-pressure liquid chromatography procedure for the analysis of ethosuximide, phenobarbitone, phenytoin, and carbamazepine in serum is described. The method employs a single extraction from serum; alumina treatment of this extract eliminates interference from fast-eluting compounds, allowing rapid chromatography. A linear response is obtained for drug concentrations up to three times the upper limit of the therapeutic ranges. Within-batch and between-batch precisions for the means of these ranges varied from 2·2 to 5·5% and from 3·1 to 7·5%, respectively.
1985 ◽
Vol 31
(2)
◽
pp. 135-144
◽
Keyword(s):
2014 ◽
Vol 27
(4)
◽
pp. 287-293
◽
1978 ◽
Vol 26
(6)
◽
pp. 1390-1393
◽
1978 ◽
Vol 67
(2)
◽
pp. 292-293
◽