HPLC Analysis of 6-Mercaptopurine and Metabolites in Extracellular Body Fluids
1988 ◽
Vol 25
(5)
◽
pp. 504-509
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Keyword(s):
A convenient HPLC assay, which allows for the simultaneous measurement in extracellular fluids of 6-mercaptopurine and four of its metabolites, 6-thioguanine, 6-mercaptopurine riboside, 6-thioxanthine and 6-thiouric acid is described. Solid phase extraction allows for the clean isolation of analytes from plasma, urine or cerebrospinal fluid. The simultaneous determination of 6-mercaptopurine and some of its major metabolites in extracellular fluids may contribute to the monitoring of patient compliance, bioavailability, and individual variation in metabolism and absorption.
1999 ◽
Vol 22
(19)
◽
pp. 2975-2990
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Keyword(s):
2003 ◽
Vol 785
(2)
◽
pp. 227-236
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2014 ◽
Vol 32
(3)
◽
pp. 263
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2011 ◽
Vol 34
(12)
◽
pp. 1375-1382
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2005 ◽
Vol 28
(11)
◽
pp. 1157-1162
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2003 ◽
Vol 798
(2)
◽
pp. 193-201
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2014 ◽
Vol 53
(2)
◽
pp. 210-218
◽
1994 ◽
Vol 83
(12)
◽
pp. 1751-1753
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