Background::
Hyperviscosity of blood secondary to polycythemia results in increased resistance to blood flow and
decrease in delivery of oxygen.
Objective::
To evaluate whether serum endocan, NSE and IMA levels can be compared in terms of endothelial injury/ dysfunction
and neuronal damage in term neonates with polycythemia who underwent PET.
Methods::
38 symptomatic polycythemic newborns having PET and 38 healthy newborns were included in the study. Blood
samples for endocan, NSE and IMA were taken at only postnatal 24 hours of age in the control group and in polycytemia
group just before PET, at 24 and 72 hours after PET.
Results::
The polycythemia group had higher serum endocan(1073,4 ± 644,8 vs. 378,8 ± 95,9ng/ml; p<0.05), IMA(1,32 ± 0,34
vs.0,601 ± 0,095absorbance unit; p<0.05) and NSE(44,7 ± 4,3 vs. 26,91 ± 7,12μg/l; p<0.05) levels than control group before
the PET procedure. At 24 hours after PET, IMA(0,656 ± 0,07 vs. 0,601 ± 0,095absorbance unit; p<0.05) and endocan(510,9
± 228,6 vs. 378,8 ± 95,9ng/ml; p<0.05) levels were closer to the control group, being still statistically significant higher. NSE
levels decreased to control group levels having no difference between the PET and control groups at 24 hours after PET (28,98
± 6,5 vs. 26,91 ± 7,12μg/l; p>0.05). At 72 hours after PET the polycythemia and control groups did not differ statistically for
IMA, endocan and NSE levels (p>0.05).
Conclusion::
Serum endocan and IMA levels can be used as a biomarker for endothelial damage / dysfunction and tissue
hypoxia in infants with symptomatic polycytemia.
A Clinical and Experimental Study of Acquired Inhibitors to Factor VIII
